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Immunotherapy and Its Applications

Description: Immunotherapy and Its Applications
Number of Questions: 15
Created by:
Tags: immunotherapy cancer treatment immune system t-cell therapy checkpoint inhibitors
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What is the primary goal of immunotherapy in cancer treatment?

  1. To directly kill cancer cells

  2. To stimulate the patient's immune system to recognize and attack cancer cells

  3. To repair damaged DNA in cancer cells

  4. To block the growth of new blood vessels in tumors


Correct Option: B
Explanation:

Immunotherapy aims to harness the power of the patient's own immune system to fight cancer by enhancing its ability to recognize and eliminate cancer cells.

Which type of immunotherapy involves genetically modifying T cells to express a receptor that targets a specific antigen on cancer cells?

  1. Adoptive T-cell therapy

  2. Checkpoint inhibitors

  3. Cancer vaccines

  4. Cytokine therapy


Correct Option: A
Explanation:

Adoptive T-cell therapy involves genetically engineering T cells to express a receptor that recognizes a specific antigen on cancer cells, enabling them to effectively target and destroy cancer cells.

What is the mechanism of action of checkpoint inhibitors in immunotherapy?

  1. They block inhibitory receptors on T cells, releasing the brakes on the immune response

  2. They directly kill cancer cells by inducing apoptosis

  3. They stimulate the production of antibodies against cancer cells

  4. They enhance the ability of natural killer cells to recognize and attack cancer cells


Correct Option: A
Explanation:

Checkpoint inhibitors work by blocking inhibitory receptors on T cells, such as PD-1 and CTLA-4, which normally prevent T cells from attacking healthy cells. By releasing these brakes, checkpoint inhibitors allow T cells to become more active and effectively target cancer cells.

What is the primary target of cancer vaccines in immunotherapy?

  1. Cancer cells themselves

  2. Immune cells such as T cells and B cells

  3. Tumor-associated antigens

  4. Cancer-promoting proteins


Correct Option: C
Explanation:

Cancer vaccines aim to stimulate the immune system to recognize and attack tumor-associated antigens, which are molecules expressed on cancer cells that are not found on healthy cells.

Which type of immunotherapy involves the administration of cytokines to enhance the immune response against cancer?

  1. Adoptive T-cell therapy

  2. Checkpoint inhibitors

  3. Cancer vaccines

  4. Cytokine therapy


Correct Option: D
Explanation:

Cytokine therapy involves the administration of cytokines, which are signaling molecules that regulate the immune response, to stimulate and enhance the immune system's ability to fight cancer.

Which type of immunotherapy involves the use of antibodies to block specific molecules involved in tumor growth and metastasis?

  1. Adoptive T-cell therapy

  2. Checkpoint inhibitors

  3. Antibody therapy

  4. Cancer vaccines


Correct Option: C
Explanation:

Antibody therapy involves the use of antibodies, which are proteins produced by the immune system to recognize and neutralize foreign substances, to target and block specific molecules involved in tumor growth and metastasis.

What is the primary advantage of immunotherapy over traditional cancer treatments such as chemotherapy and radiation therapy?

  1. It is more effective in killing cancer cells

  2. It has fewer side effects

  3. It can target cancer cells that are resistant to traditional treatments

  4. It is less expensive


Correct Option: C
Explanation:

Immunotherapy has the unique ability to target cancer cells that have become resistant to traditional treatments such as chemotherapy and radiation therapy, offering new hope for patients with advanced or recurrent cancers.

Which type of immunotherapy involves the use of oncolytic viruses to selectively infect and kill cancer cells?

  1. Adoptive T-cell therapy

  2. Checkpoint inhibitors

  3. Virotherapy

  4. Cancer vaccines


Correct Option: C
Explanation:

Virotherapy involves the use of oncolytic viruses, which are genetically engineered viruses that selectively infect and kill cancer cells while leaving healthy cells unharmed.

What is the main challenge associated with the development of cancer vaccines?

  1. The difficulty in identifying tumor-associated antigens

  2. The potential for autoimmune reactions

  3. The limited efficacy of vaccines against solid tumors

  4. The high cost of vaccine development


Correct Option: A
Explanation:

One of the main challenges in developing cancer vaccines is identifying tumor-associated antigens that are unique to cancer cells and not found on healthy cells, as these antigens are necessary for the vaccine to elicit an immune response specifically against cancer.

Which type of immunotherapy involves the use of heat to kill cancer cells and stimulate the immune system?

  1. Adoptive T-cell therapy

  2. Checkpoint inhibitors

  3. Thermal therapy

  4. Cancer vaccines


Correct Option: C
Explanation:

Thermal therapy involves the use of heat to kill cancer cells and stimulate the immune system. It can be applied locally to tumors or systemically to the entire body.

What is the primary mechanism of action of cytokine therapy in immunotherapy?

  1. It directly kills cancer cells

  2. It stimulates the production of antibodies against cancer cells

  3. It enhances the ability of natural killer cells to recognize and attack cancer cells

  4. It blocks inhibitory receptors on T cells


Correct Option: B
Explanation:

Cytokine therapy primarily works by stimulating the production of antibodies against cancer cells, enhancing the immune system's ability to recognize and target cancer cells for destruction.

Which type of immunotherapy involves the use of genetically modified bacteria to target and kill cancer cells?

  1. Adoptive T-cell therapy

  2. Checkpoint inhibitors

  3. Bacterial therapy

  4. Cancer vaccines


Correct Option: C
Explanation:

Bacterial therapy involves the use of genetically modified bacteria to target and kill cancer cells. These bacteria are engineered to selectively infect and destroy cancer cells while leaving healthy cells unharmed.

What is the primary advantage of adoptive T-cell therapy over traditional T-cell-based immunotherapies?

  1. It is more effective in killing cancer cells

  2. It has fewer side effects

  3. It can target cancer cells that are resistant to traditional treatments

  4. It is less expensive


Correct Option: C
Explanation:

Adoptive T-cell therapy has the unique ability to target cancer cells that have become resistant to traditional T-cell-based immunotherapies, offering new hope for patients with advanced or recurrent cancers.

Which type of immunotherapy involves the use of nanoparticles to deliver therapeutic agents directly to cancer cells?

  1. Adoptive T-cell therapy

  2. Checkpoint inhibitors

  3. Nanoparticle therapy

  4. Cancer vaccines


Correct Option: C
Explanation:

Nanoparticle therapy involves the use of nanoparticles to deliver therapeutic agents, such as drugs, genes, or antibodies, directly to cancer cells, enhancing their targeted delivery and effectiveness.

What is the primary challenge associated with the development of checkpoint inhibitors?

  1. The difficulty in identifying checkpoint molecules

  2. The potential for autoimmune reactions

  3. The limited efficacy of checkpoint inhibitors against solid tumors

  4. The high cost of checkpoint inhibitor development


Correct Option: B
Explanation:

One of the main challenges in developing checkpoint inhibitors is the potential for autoimmune reactions, as blocking checkpoint molecules can lead to the immune system attacking healthy cells, resulting in immune-related adverse events.

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