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B Cells and Their Role in Immunity

Description: This quiz is designed to evaluate your understanding of B cells and their crucial role in the immune system. Test your knowledge on B cell development, activation, antibody production, and their involvement in humoral immunity.
Number of Questions: 14
Created by:
Tags: immunology b cells antibodies humoral immunity
Attempted 0/14 Correct 0 Score 0

What is the primary function of B cells in the immune system?

  1. Producing antibodies

  2. Engulfing and destroying pathogens

  3. Releasing cytokines

  4. Activating T cells


Correct Option: A
Explanation:

B cells are specialized lymphocytes responsible for producing antibodies, which are proteins that recognize and neutralize specific antigens.

Where do B cells mature and differentiate into plasma cells?

  1. Bone marrow

  2. Thymus

  3. Spleen

  4. Lymph nodes


Correct Option: A
Explanation:

B cells mature and differentiate into plasma cells primarily in the bone marrow, where they undergo a process called B cell development.

What is the role of B cells in humoral immunity?

  1. Producing antibodies

  2. Killing infected cells

  3. Releasing cytokines

  4. Activating macrophages


Correct Option: A
Explanation:

B cells play a central role in humoral immunity by producing antibodies that specifically bind to and neutralize antigens, marking them for destruction by other immune cells.

What is the structure of an antibody molecule?

  1. Two heavy chains and two light chains

  2. One heavy chain and one light chain

  3. Four heavy chains and four light chains

  4. Two heavy chains and four light chains


Correct Option: A
Explanation:

An antibody molecule consists of two heavy chains and two light chains, forming a Y-shaped structure with a variable region that binds to specific antigens and a constant region that interacts with other immune cells.

What is the process by which B cells become activated and differentiate into plasma cells?

  1. Clonal selection

  2. Apoptosis

  3. Cytokine signaling

  4. Phagocytosis


Correct Option: A
Explanation:

B cells become activated through a process called clonal selection, where specific antigens bind to B cell receptors, triggering proliferation and differentiation into plasma cells, which produce large quantities of antibodies.

What is the role of memory B cells in the immune response?

  1. Producing antibodies

  2. Killing infected cells

  3. Releasing cytokines

  4. Providing long-term immunity


Correct Option: D
Explanation:

Memory B cells are long-lived B cells that remain in the body after an infection or vaccination, providing long-term immunity by rapidly producing antibodies upon re-exposure to the same antigen.

What is the difference between IgM and IgG antibodies?

  1. IgM is a monomer, while IgG is a dimer

  2. IgM is produced during the primary immune response, while IgG is produced during the secondary immune response

  3. IgM is found in saliva and tears, while IgG is found in blood and cerebrospinal fluid

  4. All of the above


Correct Option: D
Explanation:

IgM is a monomeric antibody produced during the primary immune response, found in saliva and tears. IgG is a dimeric antibody produced during the secondary immune response, found in blood and cerebrospinal fluid.

What is the role of B cells in autoimmune diseases?

  1. Producing antibodies against self-antigens

  2. Killing infected cells

  3. Releasing cytokines

  4. Activating macrophages


Correct Option: A
Explanation:

In autoimmune diseases, B cells malfunction and produce antibodies against the body's own tissues, leading to inflammation and tissue damage.

What is the role of B cells in cancer immunotherapy?

  1. Producing antibodies against cancer cells

  2. Killing infected cells

  3. Releasing cytokines

  4. Activating macrophages


Correct Option: A
Explanation:

B cells can be engineered to produce antibodies that specifically target and destroy cancer cells, a promising approach in cancer immunotherapy.

What is the role of B cells in vaccine development?

  1. Producing antibodies against pathogens

  2. Killing infected cells

  3. Releasing cytokines

  4. Activating macrophages


Correct Option: A
Explanation:

B cells play a crucial role in vaccine development by producing antibodies against specific pathogens, providing protection against future infections.

What are some common B cell disorders?

  1. Multiple myeloma

  2. Chronic lymphocytic leukemia

  3. Hodgkin lymphoma

  4. All of the above


Correct Option: D
Explanation:

Multiple myeloma, chronic lymphocytic leukemia, and Hodgkin lymphoma are examples of common B cell disorders that affect B cell development, function, or proliferation.

What is the role of B cells in the development of allergies?

  1. Producing antibodies against allergens

  2. Killing infected cells

  3. Releasing cytokines

  4. Activating macrophages


Correct Option: A
Explanation:

In allergies, B cells produce antibodies against harmless substances (allergens), leading to an exaggerated immune response and symptoms such as sneezing, runny nose, and watery eyes.

What is the role of B cells in the prevention of infections?

  1. Producing antibodies against pathogens

  2. Killing infected cells

  3. Releasing cytokines

  4. Activating macrophages


Correct Option: A
Explanation:

B cells play a critical role in preventing infections by producing antibodies that neutralize pathogens, preventing their entry into cells and causing disease.

What is the role of B cells in the maintenance of immune memory?

  1. Producing antibodies against pathogens

  2. Killing infected cells

  3. Releasing cytokines

  4. Activating macrophages


Correct Option: A
Explanation:

B cells contribute to immune memory by producing memory B cells, which remain in the body after an infection and can rapidly produce antibodies upon re-exposure to the same pathogen, providing long-term protection.

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