0

Psychopharmacology of Autism Spectrum Disorder

Description: This quiz is designed to evaluate your understanding of the psychopharmacology of Autism Spectrum Disorder (ASD). It covers various aspects of pharmacological interventions used in the management of ASD symptoms, including commonly prescribed medications, their mechanisms of action, side effects, and clinical considerations.
Number of Questions: 15
Created by:
Tags: psychopharmacology autism spectrum disorder medication management pharmacological interventions
Attempted 0/15 Correct 0 Score 0

Which of the following is NOT a commonly prescribed medication for the treatment of core symptoms of ASD?

  1. Risperidone

  2. Aripiprazole

  3. Methylphenidate

  4. Sertraline


Correct Option: D
Explanation:

Sertraline is an antidepressant medication commonly used to treat depression and anxiety disorders. It is not typically prescribed as a first-line treatment for the core symptoms of ASD.

The primary mechanism of action of atypical antipsychotics in the treatment of ASD is:

  1. Dopamine receptor antagonism

  2. Serotonin receptor antagonism

  3. Noradrenaline receptor antagonism

  4. GABA receptor agonism


Correct Option: A
Explanation:

Atypical antipsychotics primarily work by blocking dopamine receptors in the brain, particularly D2 receptors. This helps to reduce the overactivity of dopamine pathways, which is thought to contribute to the symptoms of ASD.

Which of the following side effects is commonly associated with the use of risperidone in children with ASD?

  1. Weight gain

  2. Sedation

  3. Extrapyramidal symptoms

  4. Tardive dyskinesia


Correct Option: A
Explanation:

Weight gain is a common side effect of risperidone, particularly in children and adolescents. It is important to monitor weight and provide dietary and lifestyle interventions as needed.

Aripiprazole is unique among atypical antipsychotics in its ability to:

  1. Improve social skills

  2. Reduce hyperactivity

  3. Alleviate anxiety symptoms

  4. Enhance cognitive function


Correct Option: A
Explanation:

Aripiprazole has been shown to have a specific effect on improving social skills in individuals with ASD. This is thought to be related to its partial agonist activity at dopamine D2 receptors.

Which medication is commonly used as an adjunctive therapy to atypical antipsychotics in the treatment of ASD?

  1. Methylphenidate

  2. Clonidine

  3. Guanfacine

  4. Atomoxetine


Correct Option: A
Explanation:

Methylphenidate, a stimulant medication, is often used in combination with atypical antipsychotics to address hyperactivity and attention problems in individuals with ASD.

The primary mechanism of action of methylphenidate in the treatment of ASD is:

  1. Dopamine transporter inhibition

  2. Noradrenaline transporter inhibition

  3. Serotonin transporter inhibition

  4. GABA transporter inhibition


Correct Option: A
Explanation:

Methylphenidate primarily works by inhibiting the dopamine transporter, leading to increased levels of dopamine in the synaptic cleft. This helps to improve attention and focus, and reduce hyperactivity.

Which of the following is NOT a common side effect of methylphenidate in children with ASD?

  1. Decreased appetite

  2. Insomnia

  3. Mood swings

  4. Tardive dyskinesia


Correct Option: D
Explanation:

Tardive dyskinesia is a movement disorder that is associated with the use of antipsychotics, but it is not a common side effect of methylphenidate.

Clonidine and guanfacine are commonly used in the treatment of ASD primarily to:

  1. Reduce hyperactivity

  2. Improve social skills

  3. Alleviate anxiety symptoms

  4. Enhance cognitive function


Correct Option: A
Explanation:

Clonidine and guanfacine are alpha-2 adrenergic agonists that are primarily used to reduce hyperactivity and impulsivity in individuals with ASD.

The primary mechanism of action of clonidine and guanfacine in the treatment of ASD is:

  1. Dopamine receptor antagonism

  2. Noradrenaline receptor agonism

  3. Serotonin receptor antagonism

  4. GABA receptor agonism


Correct Option: B
Explanation:

Clonidine and guanfacine primarily work by activating alpha-2 adrenergic receptors in the brain, leading to decreased noradrenaline release. This helps to reduce hyperactivity and impulsivity.

Which of the following is NOT a common side effect of clonidine or guanfacine in children with ASD?

  1. Sedation

  2. Hypotension

  3. Constipation

  4. Tardive dyskinesia


Correct Option: D
Explanation:

Tardive dyskinesia is a movement disorder that is associated with the use of antipsychotics, but it is not a common side effect of clonidine or guanfacine.

Atomoxetine is a medication that is sometimes used in the treatment of ASD primarily to:

  1. Reduce hyperactivity

  2. Improve social skills

  3. Alleviate anxiety symptoms

  4. Enhance cognitive function


Correct Option: A
Explanation:

Atomoxetine is a selective noradrenaline reuptake inhibitor that is sometimes used to reduce hyperactivity and impulsivity in individuals with ASD.

The primary mechanism of action of atomoxetine in the treatment of ASD is:

  1. Dopamine transporter inhibition

  2. Noradrenaline transporter inhibition

  3. Serotonin transporter inhibition

  4. GABA transporter inhibition


Correct Option: B
Explanation:

Atomoxetine primarily works by inhibiting the noradrenaline transporter, leading to increased levels of noradrenaline in the synaptic cleft. This helps to improve attention and focus, and reduce hyperactivity.

Which of the following is NOT a common side effect of atomoxetine in children with ASD?

  1. Nausea

  2. Vomiting

  3. Headache

  4. Tardive dyskinesia


Correct Option: D
Explanation:

Tardive dyskinesia is a movement disorder that is associated with the use of antipsychotics, but it is not a common side effect of atomoxetine.

When prescribing psychotropic medications for individuals with ASD, it is important to consider:

  1. Individualized assessment and treatment planning

  2. Careful monitoring of side effects

  3. Regular follow-up and medication adjustments as needed

  4. All of the above


Correct Option: D
Explanation:

When prescribing psychotropic medications for individuals with ASD, it is important to consider individualized assessment and treatment planning, careful monitoring of side effects, and regular follow-up and medication adjustments as needed.

Which of the following is NOT a potential risk associated with the use of psychotropic medications in individuals with ASD?

  1. Increased risk of tardive dyskinesia

  2. Weight gain

  3. Metabolic changes

  4. Improved social skills


Correct Option: D
Explanation:

Improved social skills is not a potential risk associated with the use of psychotropic medications in individuals with ASD. In fact, some medications may have a beneficial effect on social skills.

- Hide questions