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Psychopharmacology of Mood Disorders

Description: This quiz is designed to assess your knowledge of the psychopharmacology of mood disorders. It covers topics such as the neurobiology of mood disorders, the different classes of antidepressants and their mechanisms of action, and the side effects and interactions of these medications.
Number of Questions: 16
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Tags: psychopharmacology mood disorders antidepressants neurobiology
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Which of the following is not a neurotransmitter implicated in the pathophysiology of mood disorders?

  1. Serotonin

  2. Norepinephrine

  3. Dopamine

  4. Glutamate


Correct Option: D
Explanation:

Glutamate is the primary excitatory neurotransmitter in the central nervous system, and it is not directly implicated in the pathophysiology of mood disorders.

Which of the following is the most commonly prescribed class of antidepressants?

  1. Selective serotonin reuptake inhibitors (SSRIs)

  2. Serotonin-norepinephrine reuptake inhibitors (SNRIs)

  3. Tricyclic antidepressants (TCAs)

  4. Monoamine oxidase inhibitors (MAOIs)


Correct Option: A
Explanation:

SSRIs are the most commonly prescribed class of antidepressants due to their efficacy, tolerability, and low risk of side effects.

What is the mechanism of action of SSRIs?

  1. They increase the levels of serotonin in the synaptic cleft.

  2. They decrease the levels of serotonin in the synaptic cleft.

  3. They block the reuptake of serotonin into the presynaptic neuron.

  4. They inhibit the metabolism of serotonin.


Correct Option: C
Explanation:

SSRIs block the reuptake of serotonin into the presynaptic neuron, thereby increasing the levels of serotonin in the synaptic cleft.

Which of the following is a common side effect of SSRIs?

  1. Nausea

  2. Headache

  3. Diarrhea

  4. Sexual dysfunction


Correct Option: D
Explanation:

Sexual dysfunction is a common side effect of SSRIs, particularly in men.

Which of the following is a contraindication to the use of MAOIs?

  1. Hypertension

  2. Pheochromocytoma

  3. Thyroid disease

  4. Bipolar disorder


Correct Option: B
Explanation:

MAOIs are contraindicated in patients with pheochromocytoma due to the risk of hypertensive crisis.

What is the mechanism of action of TCAs?

  1. They block the reuptake of serotonin and norepinephrine into the presynaptic neuron.

  2. They increase the levels of serotonin and norepinephrine in the synaptic cleft.

  3. They decrease the levels of serotonin and norepinephrine in the synaptic cleft.

  4. They inhibit the metabolism of serotonin and norepinephrine.


Correct Option: A
Explanation:

TCAs block the reuptake of serotonin and norepinephrine into the presynaptic neuron, thereby increasing the levels of these neurotransmitters in the synaptic cleft.

Which of the following is a common side effect of TCAs?

  1. Anticholinergic effects

  2. Cardiotoxicity

  3. Seizures

  4. Weight gain


Correct Option: A
Explanation:

Anticholinergic effects, such as dry mouth, blurred vision, and constipation, are common side effects of TCAs.

Which of the following is a newer class of antidepressants that is effective in treating treatment-resistant depression?

  1. Ketamine

  2. Esketamine

  3. Lithium

  4. Valproate


Correct Option: A
Explanation:

Ketamine is a newer class of antidepressant that has been shown to be effective in treating treatment-resistant depression.

What is the mechanism of action of ketamine?

  1. It blocks the NMDA receptor.

  2. It increases the levels of glutamate in the synaptic cleft.

  3. It decreases the levels of glutamate in the synaptic cleft.

  4. It inhibits the metabolism of glutamate.


Correct Option: A
Explanation:

Ketamine blocks the NMDA receptor, which is a glutamate receptor.

Which of the following is a common side effect of ketamine?

  1. Dissociation

  2. Nausea

  3. Headache

  4. Seizures


Correct Option: A
Explanation:

Dissociation is a common side effect of ketamine, which can range from mild to severe.

Which of the following is a mood stabilizer that is used to treat bipolar disorder?

  1. Lithium

  2. Valproate

  3. Lamotrigine

  4. Carbamazepine


Correct Option: A
Explanation:

Lithium is a mood stabilizer that is used to treat bipolar disorder.

What is the mechanism of action of lithium?

  1. It inhibits the reuptake of serotonin and norepinephrine.

  2. It increases the levels of serotonin and norepinephrine in the synaptic cleft.

  3. It decreases the levels of serotonin and norepinephrine in the synaptic cleft.

  4. It inhibits the metabolism of serotonin and norepinephrine.


Correct Option: C
Explanation:

Lithium decreases the levels of serotonin and norepinephrine in the synaptic cleft.

Which of the following is a common side effect of lithium?

  1. Nausea

  2. Vomiting

  3. Diarrhea

  4. Tremor


Correct Option: D
Explanation:

Tremor is a common side effect of lithium.

Which of the following is an anticonvulsant that is used to treat bipolar disorder?

  1. Valproate

  2. Lamotrigine

  3. Carbamazepine

  4. Phenytoin


Correct Option: A
Explanation:

Valproate is an anticonvulsant that is used to treat bipolar disorder.

What is the mechanism of action of valproate?

  1. It blocks the voltage-gated sodium channels.

  2. It increases the levels of GABA in the synaptic cleft.

  3. It decreases the levels of GABA in the synaptic cleft.

  4. It inhibits the metabolism of GABA.


Correct Option: A
Explanation:

Valproate blocks the voltage-gated sodium channels, which inhibits the release of neurotransmitters.

Which of the following is a common side effect of valproate?

  1. Nausea

  2. Vomiting

  3. Diarrhea

  4. Hepatotoxicity


Correct Option: D
Explanation:

Hepatotoxicity is a common side effect of valproate, particularly in children.

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