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Drug Allergies and Hypersensitivity Reactions

Description: Test your knowledge on Drug Allergies and Hypersensitivity Reactions with this comprehensive quiz. Assess your understanding of the causes, symptoms, diagnosis, and management of these reactions.
Number of Questions: 15
Created by:
Tags: drug allergies hypersensitivity reactions pharmacology immunology
Attempted 0/15 Correct 0 Score 0

What is the most common type of drug allergy?

  1. Anaphylaxis

  2. Hives

  3. Eczema

  4. Contact dermatitis


Correct Option: B
Explanation:

Hives, also known as urticaria, are the most common type of drug allergy. They are characterized by raised, itchy, red welts on the skin.

Which drug class is most commonly associated with anaphylaxis?

  1. Penicillins

  2. Cephalosporins

  3. Sulfonamides

  4. Non-steroidal anti-inflammatory drugs (NSAIDs)


Correct Option: A
Explanation:

Penicillins are the drug class most commonly associated with anaphylaxis, a severe and potentially life-threatening allergic reaction.

What is the mechanism of immediate hypersensitivity reactions?

  1. Activation of complement cascade

  2. Release of histamine and other mediators from mast cells and basophils

  3. Formation of immune complexes

  4. Activation of cytotoxic T cells


Correct Option: B
Explanation:

Immediate hypersensitivity reactions are mediated by the release of histamine and other mediators from mast cells and basophils upon exposure to an allergen.

Which type of hypersensitivity reaction is characterized by the formation of immune complexes?

  1. Type I

  2. Type II

  3. Type III

  4. Type IV


Correct Option: C
Explanation:

Type III hypersensitivity reactions are characterized by the formation of immune complexes, which can activate complement and lead to tissue damage.

What is the most common type of delayed hypersensitivity reaction?

  1. Contact dermatitis

  2. Tuberculin skin test

  3. Graft-versus-host disease

  4. Serum sickness


Correct Option: A
Explanation:

Contact dermatitis is the most common type of delayed hypersensitivity reaction. It is caused by direct contact with an allergen, such as poison ivy or nickel.

Which test is used to diagnose penicillin allergy?

  1. Skin prick test

  2. Intradermal skin test

  3. Patch test

  4. Radioallergosorbent test (RAST)


Correct Option: A
Explanation:

Skin prick test is the most commonly used test to diagnose penicillin allergy. It involves pricking the skin with a needle containing a small amount of penicillin and observing for a reaction.

What is the first-line treatment for anaphylaxis?

  1. Epinephrine

  2. Antihistamines

  3. Corticosteroids

  4. Bronchodilators


Correct Option: A
Explanation:

Epinephrine is the first-line treatment for anaphylaxis. It is a potent vasoconstrictor and bronchodilator that can help to reverse the symptoms of anaphylaxis.

Which drug class is most commonly used to prevent allergic reactions to penicillin?

  1. Cephalosporins

  2. Sulfonamides

  3. Tetracyclines

  4. Macrolides


Correct Option: A
Explanation:

Cephalosporins are the drug class most commonly used to prevent allergic reactions to penicillin. They are structurally similar to penicillin, but they are less likely to cause allergic reactions.

What is the recommended duration of desensitization therapy for penicillin allergy?

  1. 1 hour

  2. 4 hours

  3. 8 hours

  4. 12 hours


Correct Option: C
Explanation:

The recommended duration of desensitization therapy for penicillin allergy is 8 hours. This involves gradually increasing the dose of penicillin over a period of time until the patient can tolerate the full dose without an allergic reaction.

Which type of hypersensitivity reaction is characterized by the activation of cytotoxic T cells?

  1. Type I

  2. Type II

  3. Type III

  4. Type IV


Correct Option: B
Explanation:

Type II hypersensitivity reactions are characterized by the activation of cytotoxic T cells, which can directly kill target cells.

What is the most common cause of drug-induced liver injury?

  1. Acetaminophen

  2. Ibuprofen

  3. Aspirin

  4. Statins


Correct Option: A
Explanation:

Acetaminophen is the most common cause of drug-induced liver injury. It can cause liver damage if taken in high doses or for a long period of time.

Which drug class is most commonly associated with Stevens-Johnson syndrome and toxic epidermal necrolysis?

  1. Sulfonamides

  2. Anticonvulsants

  3. Non-steroidal anti-inflammatory drugs (NSAIDs)

  4. Allopurinol


Correct Option: A
Explanation:

Sulfonamides are the drug class most commonly associated with Stevens-Johnson syndrome and toxic epidermal necrolysis, which are severe and potentially life-threatening skin reactions.

What is the most common cause of drug-induced agranulocytosis?

  1. Penicillins

  2. Cephalosporins

  3. Sulfonamides

  4. Antithyroid drugs


Correct Option: D
Explanation:

Antithyroid drugs, such as propylthiouracil and methimazole, are the most common cause of drug-induced agranulocytosis, a condition characterized by a severe decrease in the number of neutrophils.

Which drug class is most commonly associated with aplastic anemia?

  1. Chloramphenicol

  2. Sulfonamides

  3. Anticonvulsants

  4. Non-steroidal anti-inflammatory drugs (NSAIDs)


Correct Option: A
Explanation:

Chloramphenicol is the drug class most commonly associated with aplastic anemia, a condition characterized by a severe decrease in the production of all blood cells.

What is the most common cause of drug-induced hemolytic anemia?

  1. Penicillins

  2. Cephalosporins

  3. Sulfonamides

  4. Quinine


Correct Option: D
Explanation:

Quinine is the most common cause of drug-induced hemolytic anemia, a condition characterized by the destruction of red blood cells.

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