Russell Crowe won an Academy Award for his portrayal of John Nash, a brilliant mathematician who struggles with schizophrenia.

Christian Bale's portrayal of Patrick Bateman, a wealthy investment banker who is also a serial killer, is considered one of the most iconic performances in cinema.

Natalie Portman won an Academy Award for her portrayal of Nina Sayers, a ballerina who struggles with mental illness.

Leonardo DiCaprio's portrayal of Howard Hughes, a wealthy industrialist and aviator who struggles with OCD, is considered one of his best performances.

Bradley Cooper's portrayal of Pat Solitano, a man who struggles with bipolar disorder, is both heartbreaking and inspiring.

Brie Larson won an Academy Award for her portrayal of Joy Newsome, a woman who is held captive in a room for seven years.

Christian Bale's portrayal of Trevor Reznik, a machinist who suffers from insomnia and hallucinations, is one of his most intense performances.

Winona Ryder's portrayal of Susanna Kaysen, a young woman who is admitted to a psychiatric hospital, is both powerful and moving.

Dustin Hoffman won an Academy Award for his portrayal of Raymond Babbitt, a man with Asperger's syndrome.

Toni Collette's portrayal of Tara Gregson, a woman with dissociative identity disorder, is both complex and compassionate.

Vincent Cassel's portrayal of Ambrosio, a monk who struggles with OCD, is both disturbing and thought-provoking.

Rachel Weisz's portrayal of Abigail Salmon, a woman who is grieving the loss of her daughter, is both powerful and heartbreaking.

Joseph Gordon-Levitt's portrayal of Lyle, a man who struggles with bipolar disorder, is both raw and emotional.

Rooney Mara's portrayal of Lisbeth Salander, a young woman with borderline personality disorder, is both haunting and unforgettable.

Leonardo DiCaprio's portrayal of Teddy Daniels, a U.S. Marshal who investigates a mental institution, is both intense and disturbing.