The Cosby Show, which aired from 1984 to 1992, was the first television show to feature an African American family as the main characters.

The George Lopez Show, which aired from 2002 to 2007, was the first television show to feature a Latino family as the main characters.

Fresh Off the Boat, which aired from 2015 to 2020, was the first television show to feature an Asian American family as the main characters.

Reservation Dogs, which aired in 2021, was the first television show to feature a Native American family as the main characters.

Modern Family, which aired from 2009 to 2020, was the first television show to feature a multiracial family as the main characters.

Orange Is the New Black, which aired from 2013 to 2019, was the first television show to feature a transgender character as a main character.

The OA, which aired from 2016 to 2019, was the first television show to feature a non-binary character as a main character.

Glee, which aired from 2009 to 2015, was the first television show to feature a character with a disability as a main character.

Crazy Ex-Girlfriend, which aired from 2015 to 2019, was the first television show to feature a character with a mental illness as a main character.

An Early Frost, which aired in 1985, was the first television show to feature a character with HIV/AIDS as a main character.

St. Elsewhere, which aired from 1982 to 1988, was the first television show to feature a character with cancer as a main character.

House, which aired from 2004 to 2012, was the first television show to feature a character with a chronic illness as a main character.

Six Feet Under, which aired from 2001 to 2005, was the first television show to feature a character with a terminal illness as a main character.

13 Reasons Why, which aired from 2017 to 2020, was the first television show to feature a character who dies by suicide as a main character.

Law & Order: Special Victims Unit, which aired from 1999 to the present, was the first television show to feature a character who is a victim of sexual assault as a main character.