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Thymus - class-XII

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Mammals born without a thymus gland fail to manufacture 

  1. B - Lymphocytes

  2. T - Lymphocytes

  3. Plasma cells

  4. Basophils


Correct Option: B
Explanation:

Removal of the thymus gland in the adult has little effect, but when the thymus is removed in the newborn, T cells in the blood and lymphoid tissue are depleted and failure of the immune system causes a gradual, fatal wasting disease. 

The animal whose thymus has been removed at birth is less able to reject foreign tissue grafts or to make antibodies to certain antigens. Moreover, certain parts of the white pulp of the spleen and lymph nodes are much reduced in size. Hence, the T cells produced in the thymus and transported to the lymphoid tissues are crucial elements in the development of immunity.

T-cells mature in the

  1. Peyer's patch

  2. Lymph node

  3. Thymus

  4. Bursa of fabricius


Correct Option: C
Explanation:

T cells or T lymphocytes are a type of lymphocyte, that plays a central role in cell-mediated immunity. They are called as T-cells because they mature in the thymus gland.

Damage to thymus in a child may lead to

  1. Loss of cell mediated immunity

  2. A reduction in the haemoglobin content in blood

  3. A reduction in the amount of plasma proteins

  4. Loss of antibody mediated immunity


Correct Option: A
Explanation:

The thymus gland is an organ in the upper chest cavity, that processes lymphocytes, a type of white blood cell, that fights infections in the body. 

The thymus is most important in children and young adults, when it programs lymphocytes to attack antigens, like viruses. 
People who do not have this gland, or in whom it does not function correctly, usually have compromised immune systems and difficulty fighting disease.

Which gland decreases in size with increasing age?

  1. Thyroid

  2. Adrenal

  3. Thymus

  4. Pituitary


Correct Option: C
Explanation:

The thymus is a specialized organ of the immune system. Within the thymus, T cells or T lymphocytes mature. At birth, it is about 5 cm in length, 4 cm in breadth, and about 6 mm in thickness. The organ enlarges during childhood and atrophies at puberty. The thymus is at its largest in children. The thymus reaches maximum weight (20 to 37 grams) by the time of puberty. As one ages, the thymus slowly shrinks, eventually degenerating into tiny islands of fatty tissue. By the age of 75 years, the thymus weighs only 6 grams.

Hassall's corpuscles are found in 

  1. Pineal body

  2. Thymus gland

  3. Thyroid gland

  4. Adrenal gland


Correct Option: B
Explanation:

Hassall's corpuscles (or thymic corpuscles) are structures found in the medulla of the human thymus, formed from eosinophilic type VI epithelial reticular cells arranged concentrically. 

The cytoplasm in Hassalls corpuscles contains keratohyalin granules and intermediate fibres and may be keratinised. 

Thymus gland develops from embryonic 

  1. Mesoderm

  2. Endoderm

  3. Ectoderm

  4. All of the above


Correct Option: B
Explanation:

The triploblastic animals have three prominent germ layers known as ectoderm, endoderm and mesoderm. Thymus gland develops from two hollow elongations (third and fourth pharyngeal pouches) of endoderm which descends to the embryonic thorax by the end of eight weeks of gestation. The lymphoid cells of the gland originate from mesoderm. Thus, the correct answer is option B.

Which endocrine gland is not an ectodermal origin?

  1. Pineal body

  2. Anterior pituitary

  3. Adrenal medulla

  4. Thymus


Correct Option: D
Explanation:

Endoderm, the innermost of the three germ layers, or masses of cells (lying within ectoderm and mesoderm), which appears early in the development of an animal embryo. The endoderm subsequently gives rise to the epithelium (tissue that covers, or lines, a structure) of the pharynx, including the eustachian tube, the tonsils, the thyroid gland, parathyroid glands, and thymus gland; the larynx, trachea, and lungs; the gastrointestinal tract (except mouth and anus), the urinary bladder, the vagina (in females), and the urethra. 

If thymectomy is done during adulthood then what is the probable result of it?

  1. Immunosuppressant

  2. Die immediately

  3. No adverse reaction

  4. Myasthenia gravis


Correct Option: C
Explanation:

Thymectomy is the process in which the thymus gland is removed. Thymus gland is located in the chest area. Thymus gland is responsible for T-cell differentiation. The gland is recommended to be removed in cases of people suffering from Myasthenia gravis. The gland is removed in childhood, which generally have no adverse effects. However, when the gland is removed in adulthood, certain immune functions get affected. T-cells differentiation may be affected leading to improper production of T-cells.

So, the correct answer is option C. 

The gland which is related to the maturation of lymphocytes is

  1. Thymus

  2. Thyroid

  3. Adrenal

  4. Pituitary


Correct Option: A
Explanation:

Thymus is small lymphoid structure present in lower art of neck in front of trachea, below the thyroid gland. It is the primary source of lymphocytes before birth and is the site of maturation or development of T-lymphocytes which circulates in lymphoid tissues. 

Which endocrine gland becomes inactive after puberty?

  1. Thyroid

  2. Parathyroid

  3. Thymus

  4. Gonads


Correct Option: C
Explanation:

Thymus becomes inactive after puberty and shrinks. Most of the glands is replaced by adipose tissue. It produces thymosin which stimulates the development of disease-fighting T cells. The immune system produces most of its T cells during childhood and requires very few new T cells after puberty so the gland degenerates.

So, the correct answer is 'Thymus'.

Ageing is caused by disappearance of 
Or
Which one of the following is gradually reduced and degenerated in ageing according to immunity theory 
Or
Which is called "Clock of ageing"

  1. Thyroid

  2. Parathyroids

  3. Thymus

  4. Pitutary


Correct Option: C
Explanation:
The thymus gland is a small irregular shaped gland in the mediastinum. 
The gland is part of both endocrine systems as well as the lymphatic system of the body. 
This gland gradually reduces in size as the age of person advances thus it is degenerated in ageing according to the immunity theory. 
Thus, the gland is also called a 'Clock of Ageing'.
So, the correct answer is 'Thymus'.

According to one of the theories of ageing, the decline and disappearance of which gland by late middle age is the primary cause of ageing? 

  1. Thyroid

  2. Parathyroid

  3. Thymus

  4. Posterior lobe of pituitary


Correct Option: C
Explanation:
A. Thyroid gland is situated between the trachea and larynx in the neck and secretes thyroxine hormone which increases oxygen consumption by metabolically active tissues.
B. Parathyroid gland is present in the form of four small pouches which are embedded in the posterior surface of lobes of thyroid gland. This gland secretes parathormone which increases calcium reabsorption from the bones and causes mobilisation of calcium in the blood.
C. Thymus gland is associated with the development of immune system and present on the dorsal side of heart. This gland shows maximum development in children during puberty and by the age of 70, it becomes a tiny structure.
D. Posterior lobe of pituitary is known as neurohypophysis and secretes oxytocin and vasopressin hormone.
Hence, disappearance of thymus gland is primary cause of ageing because immune system of body is affected due to retardation of thymus gland leading to weak immunity.
So, the correct answer is 'Thymus'.

Which of these is related to the maturation of lymphocytes?

  1. Thymus

  2. Thyroid

  3. Adrenal

  4. Pituitary


Correct Option: A
Explanation:
A. Thymus gland is associated with the development of immune system and present on the dorsal side of heart. It secretes thymosin hormone which plays an important role in the differentiation of T-lymphocytes.
B. Thyroid gland is situated between the trachea and larynx in the neck and secretes thyroxine hormone which increases oxygen consumption by metabolically active tissues.
C. Adrenal gland is present on upper side of kidneys and has two parts, adrenal cortex which secrete glucocorticoids, mineralocorticoids and sexocorticoids and adrenal medulla which secrete adrenaline and nor-adrenaline hormone.
D. Pituitary gland is the master gland that regulates the activity of other endocrine glands and secretes many hormones like growth hormone, follicle stimulating hormone, thyroid stimulating hormone etc.
So, the correct answer is 'Thymus'.

Which of the following glands grows to the maximum size at puberty and then diminishes gradually? 

  1. Thymus

  2. Pituitary

  3. Thyroid

  4. Adrenal


Correct Option: A
Explanation:
A. Thymus gland is associated with the development of immune system and present on the dorsal side of heart. It secretes thymosin hormone which plays an important role in the differentiation of T-lymphocytes. This gland shows maximum development in children during puberty and after that, it starts diminishing gradually and by the age of 70, it becomes a tiny structure.
B. Pituitary gland is the master gland that regulates the activity of other endocrine glands and secretes many hormones like growth hormone, follicle stimulating hormone, thyroid stimulating hormone etc.
C. Thyroid gland is situated between the trachea and larynx in the neck and secretes thyroxine hormone which increases oxygen consumption by metabolically active tissues.
D. Adrenal gland is present on upper side of kidneys and has two parts, adrenal cortex which secrete glucocorticoids, mineralocorticoids and sexocorticoids and adrenal medulla which secrete adrenaline and nor-adrenaline hormone.
So, the correct answer is 'Thymus'.

Endocrine gland responsible for immunity is 

  1. Pineal

  2. Thymus

  3. Pituitary

  4. Adrenal


Correct Option: B
Explanation:
A. Pineal gland is a small, rounded and reddish brown gland present at the dorsal side of forebrain. This gland secretes melatonin and serotonin hormones.
B. Thymus gland is associated with the development of immune system and present on the dorsal side of heart. It secretes thymosin hormone which plays an important role in the differentiation of T-lymphocytes.
C. Pituitary gland is the master gland that regulates the activity of other endocrine glands and secretes many hormones like growth hormone, follicle stimulating hormone, thyroid stimulating hormone etc.
D. Adrenal gland is present on upper side of kidneys and has two parts, adrenal cortex which secrete glucocorticoids, mineralocorticoids and sexocorticoids and adrenal medulla which secrete adrenaline and nor-adrenaline hormone.
So, the correct answer is 'Thymus'.

Removal or absence of thymus in early life shall bring about

  1. Lack of lymphocytes

  2. Lack of antibodies

  3. Decreased immune response

  4. All of the above


Correct Option: D
Explanation:
Thymus gland is associated with the development of immune system and present on the dorsal side of heart. It shows maximum development in children during puberty and by the age of 70, it transforms into a tiny structure. It secretes thymosin hormone which plays an important role in the differentiation of T-lymphocytes which are associated with cell mediated immunity. It also promotes production of antibodies that induce humoral immunity.
Hence, lack of thymus gland will result in lack of lymphocytes and antibodies and decreased immune response. Thus, all the options are correct.
So, the correct answer is 'All of the above'.

Which endocrine gland becomes inactive after puberty?

  1. Adrenal

  2. Pineal

  3. Thymus

  4. Pituitary


Correct Option: C
Explanation:
A. Adrenal gland is present on upper side of kidneys and has two parts, adrenal cortex which secrete glucocorticoids, mineralocorticoids and sexocorticoids and adrenal medulla which secrete adrenaline and nor-adrenaline hormone.
B. Pineal gland is a small, rounded and reddish brown gland present at the dorsal side of forebrain. This gland secretes melatonin and serotonin hormones.
C. Thymus gland is associated with the development of immune system and present on the dorsal side of heart. It secretes thymosin hormone which plays an important role in the differentiation of T-lymphocytes. This gland shows maximum development in children during puberty and after that, it starts diminishing gradually and by the age of 70, it becomes a tiny structure.
D. Pituitary gland is the master gland that regulates the activity of other endocrine glands and secretes many hormones like growth hormone, follicle stimulating hormone, thyroid stimulating hormone etc.
Hence, thymus becomes inactive after puberty.
So, the correct answer is 'Thymus'.

Hassall's corpuscles are found in

  1. Thyroid

  2. Thymus

  3. Adrenal

  4. Pineal


Correct Option: B
Explanation:
A. Thyroid gland is situated between the trachea and larynx in the neck and secretes thyroxine hormone which increases oxygen consumption by metabolically active tissues.
B. Thymus gland is associated with the development of immune system and present on the dorsal side of heart. It secretes thymosin hormone which plays an important role in the differentiation of T-lymphocytes.
C. Adrenal gland is present on upper side of kidneys and has two parts, adrenal cortex which secrete glucocorticoids, mineralocorticoids and sexocorticoids and adrenal medulla which secrete adrenaline and nor-adrenaline hormone. Adrenaline is secreted in response to stress in the body and is known as emergency hormone. Thus, adrenal gland is an emergency gland.
D. Pineal gland is a small, rounded and reddish brown gland present at the dorsal side of forebrain. This gland secretes melatonin and serotonin hormones.
Hassall's corpuscles are known as thymic bodies. They are present in the medulla of thymus.
So, the correct answer is 'Thymus'.

An endocrine gland that atrophies at the age of 14 - 16 years is

  1. Thyroid

  2. Thymus

  3. Pancreas

  4. Spleen


Correct Option: B
Explanation:
A. Thyroid gland is situated between the trachea and larynx in the neck and secretes thyroxine hormone which increases oxygen consumption by metabolically active tissues.
B. Thymus gland secretes thymosin hormone which plays an important role in the differentiation of T-lymphocytes. This gland shows maximum development in children at the time of puberty (10-14 years) and after that it starts decreasing in size.
C. Pancreas is a heterocrine gland as it acts both as endocrine and exocrine gland. It secretes insulin hormone into blood and act as endocrine gland and when it secretes digestive enzymes and juice through pancreatic duct, it acts as exocrine gland.
D. Spleen is a organ of immune system which produces blood cells.
So, the correct answer is 'Thymus'.

Which of these is correctly matched with the accompanying description?

  1. Pancreas - Delta cells of islets of Langerhans secrete a hormone which stimulates glycolysis in liver

  2. Thyroid - Hyperactivity in young children causes cretinism

  3. Thymus - Starts undergoing atrophy after puberty

  4. Parathyroid - Secretes parathormone that promotes movement of $Ca^{2+}$ ions from blood into bones during calcification


Correct Option: C
Explanation:
A. The delta cells of islets of Langerhans of pancreas secrete somatostatin hormone which inhibits secretion of glucagon and insulin.
B. Cretinism is the retarded mental and physical development in children due to hyposecretion of thyroid hormones.
C. Thymus gland shows maximum development in children during puberty and after that it starts degenerating.
D. Parathormone is secreted from the parathyroid hormone and increases blood calcium level by increasing the reabsorption of calcium from the bones.
So, the correct answer is 'Thymus - Starts undergoing atrophy after puberty'.

Which of these has a role in immunity?

  1. Pineal gland

  2. Thymus

  3. Adrenal gland

  4. Parathyroid gland


Correct Option: B
Explanation:
Thymus gland is associated with the development of immune system and present on the dorsal side of heart. It contains lymphoid tissue that plays an important role in proliferation and maturation of T-lymphocytes. It secretes thymosin hormone which plays an important role in the differentiation of T-lymphocytes which are associated with cell mediated immunity. Thymosin also promotes formation of antibodies for humoral immunity. 
So, the correct answer is 'Thymus'.

Thymosin hormone is secreted by 

  1. Thyreid

  2. Thymus

  3. Parathyroid

  4. Hypothalamus


Correct Option: B
Explanation:
A. Thyroid gland is situated between the trachea and larynx in the neck and secretes thyroxine hormone which increases oxygen consumption by metabolically active tissues.
B. Thymus gland is associated with the development of immune system and present on the dorsal side of heart. It secretes thymosin hormone which plays an important role in the differentiation of T-lymphocytes.
C. Parathyroid gland is present in the form of four small pouches which are embedded in the posterior surface of lobes of thyroid gland. This gland secretes parathormone which increases calcium reabsorption from the bones and causes mobilisation of calcium in the blood.
D. Hypothalamus is present in the forebrain. This gland secretes hormones that regulate the synthesis and secretion of hormones of pituitary gland. 
So, the correct answer is 'Thymus'.

Thymus gland has a role in 

  1. $Na^+$ $K^+$ balance

  2. Immune system

  3. Maintaining glucose level

  4. Maintaining $Ca^{2+}$ level


Correct Option: B
Explanation:
Thymus gland is a lobular gland present on dorsal side of heart. It is associated with the development of immune system. It contains lymphoid tissue that plays an important role in proliferation and maturation of T-lymphocytes. It secretes thymosin hormone which plays an important role in the differentiation of T-lymphocytes which are associated with cell mediated immunity. Thymosin also promotes formation of antibodies for humoral immunity. It also controls resistance to infection and formation of lymphocytes. Thymus gland degenerates with age resulting in decreased production of thymosin. That's why older people have weak immunity. 
So, the correct answer is 'Immune system'.

Which of these is the correct combination for gland, hormone and its function?

  1. Anterior pituitary - oxytocin - contraction of uterine muscles

  2. Anterior pituitary - vasopressin - induces reabsorption of water in nephron

  3. Thymus - thymosin - proliferation of T-lymphocytes

  4. $\alpha$-cells - glucagon - uptake of glucose by cells


Correct Option: C
Explanation:
A. Oxytocin is secreted from the posterior pituitary and helps in the contraction of uterus during childbirth and also stimulates release of milk from mammary glands i.e. lactation.
B. Vasopressin or Anti diuretic hormone (ADH), is secreted from the posterior part of pituitary gland. This hormone increases reabsorption of water in kidneys and this results in decreased rate of urine production.
C. Thymus gland is associated with the development of immune system and present on the dorsal side of heart. It secretes thymosin hormone which plays an important role in the differentiation of T-lymphocytes.
D. Glucagon is secreted from αα-cells of islets of Langerhans of pancreas. It increases blood sugar level by stimulating glycogenolysis (i.e. break down of glucose) and gluconeogenesis (synthesis of glucose).
Hence, option C is the correct combination for gland, hormone and its function.
So, the correct answer is 'Thymus - thymosin - proliferation of T-lymphocytes'.

Which is not the function of endocrine gland, located in upper dorsal side of heart and aorta?

  1. Plays important role in development of immune system

  2. Induces differentiation of T-lymphocytes

  3. Induces formation of RBCs

  4. Induces development of T-lymphocytes


Correct Option: C
Explanation:
Thymus gland is a lobular structure present on dorsal side of heart and aorta. It is associated with the development of immune system. This gland consists of lymphoid tissue which plays an important role in the maturation and proliferation of T-lymphocytes. It secretes thymosin hormone which stimulates differentiation of T-lymphocytes associated with cell-mediated immunity. Thymosin also promotes formation of antibodies for humoral immunity.
RBCs formation is induced by erythropoietin secreted from juxtaglomerular cells of kidney. 
So, the correct answer is 'Induces formation of RBCs'. 

Which of the following helps in differentiation of cells of immune system?

  1. Cortisol

  2. Thyroxine

  3. Thymosin

  4. Steroid


Correct Option: C
Explanation:
A. Cortisol is secreted by adrenal cortex of adrenal gland. It produces anti-inflammatory reactions and suppresses the immune response.
B. Thyroxine is secreted by thyroid hormone. It controls basal metabolic rate and physical growth.
C. Thymosin is secreted by thymus gland. It plays a major role in the differentiation of T -lymphocytes which provide cell-mediated immunity.
D. Steroids are secreted by adrenal cortex of adrenal medulla. Example aldosterone, cortisol, androgens.
So, the correct answer is 'Thymosin'.

The letter T in T-lymphocyte refers to :

  1. Thymus

  2. Thyroid

  3. Thalamus

  4. Tonsil


Correct Option: A

Which of the following glands is lost as the age advances?

  1. Thyroid

  2. Thymus

  3. Pancreas

  4. Adrenal


Correct Option: B
Explanation:

Thymus glands is a specialised lymphoid organ of the immune system. It helps in the maturation of the T cells. it plays an important role during the puberty at the adolescence stage.  After puberty, it degenerates and it is replaced by fat. This shrinkage of thymus mainly takes place due to a high level of sex hormones.

So, the correct answer is option B.

The name of endocrine gland in the human brain is

  1. Thyroid

  2. Adrenal

  3. Thymus

  4. Pituitary


Correct Option: D
Explanation:
Endocrine glands are group of secretory cells surrounded by an extensive network of capillaries that facilitates diffusion of hormones into the bloodstream. These glands include Pituitary gland, Pineal body, thymus, thyroid, parathyroid, adrenal glands, etc.
Thyroid gland is situated in the neck in front of the larynx and trachea at the level of 5th, 6th and 7th cervical and 1st thoracic vertebrae. The two adrenal glands are situated on the upper pole of each kidney enclosed within the renal fascia. The thymus is a soft gland located behind the breastbone and between the lungs. The pituitary gland is a pea sized structure located at the base of the brain, just below the hypothalamus.
So, the answer is D.

Which of the following do not play any role in calcium balance in the human body?

  1. Vitamin D

  2. Parathyroid hormone

  3. Thyrocalcitonin

  4. Thymosin


Correct Option: D
Explanation:
Thymosin is a hormone released by the thymus. It has a major role in the maturation of the T lymphocytes. It has no role in maintaining the calcium balance in the body.
Thus, the correct answer is 'Thymosin.'

Which gland atrophies in adults?

  1. Pancreas gland

  2. Thymus gland

  3. Adrenal gland

  4. Thyroid gland


Correct Option: B
Explanation:

Thymus gland is a prominent gland at birth but gradually atrophies in the adult. It is a soft, pinkish, bilobed mass of lymphoid tissue. It secretes a hormone thymosin which is involved in producing immunity.

Which one of the following is termed temporary gland?

  1. Pineal

  2. Thymus

  3. Pancreas

  4. Kidney


Correct Option: B
Explanation:

Thymus is called temporary gland as it degenerates in old individuals resulting in a decreased production of thymosin.

The regression in size of which organ is associated with reduction in the power of defence against invasion by pathogens with ageing?

  1. Bone marrow

  2. Thymus

  3. Spleen

  4. Peyer's patches


Correct Option: B
Explanation:

The thymus gland, located behind our sternum and between our lungs, is only active until puberty.

After puberty, the thymus starts to slowly shrink and become replaced by fat.
So, the correct option is 'Thymus'.

Central tolerance takes place in

  1. Lymph nodes

  2. Thymus

  3. Spleen

  4. Liver


Correct Option: B
Explanation:

Central tolerance is the tolerance established by deleting autoreactive lymphocyte clones before they develop into fully grown immunocompetent cells. It occurs primarily in the thymus.

So, the correct option is 'Thymus'.

Which one of these does not pertain to B-cells?

  1. Have passed through the thymus

  2. Synthesize and liberate antibodies

  3. Have antibody-mediated immunity

  4. Have specific receptors


Correct Option: A
Explanation:

B cells develop in the bone marrow but achieve maturity in peripheral lymphoid organs. Developmental stages are defined by the successful expression of heavy-chain and light-chain immunoglobulin genes. B cells provide humoral immunity against extracellular pathogens through antibody production. Antibodies neutralize pathogens and toxins, facilitate opsonization, and activate complement. The B-cell receptor or BCR is composed of immunoglobulin molecules that form a type 1 transmembrane receptor protein usually located on the outer surface of a lymphocyte type known as B cells. 


So, the correct option is 'Option A'.

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