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Blood groups and transfusion - class-XI

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Which of the following cells play an important role in failure of transplanted organ?

  1. $CD _4$ cells and $CD _8$ cells

  2. Natural killer cells

  3. Plasma cells

  4. Mast cells


Correct Option: A

The possible blood groups of children born to parents having A and AB blood groups are?

  1. O, A

  2. O, A, B

  3. A, B, AB

  4. O, A, B, AB


Correct Option: A

Antibody common to blood group $O^-$ and individual with blood group $B^+$ is /are 

  1. Anti -B

  2. Anti A

  3. Both Anti B and Anti A

  4. Anti -RH


Correct Option: A

Persons with blood group A possess

  1. Antigen A and antibodies b

  2. Antigen A and antibodies a

  3. No antigen but antibodies a and b

  4. Antigens A and B but no antibodies.


Correct Option: A

A man with blood group AB' marries a woman withO' blood group. In this situation

  1. The blood groups of their children will be the same as that of the mother

  2. The blood group of the children differs from both the parents

  3. While 50% of children will have father's blood group, the remaining will have mother's blood group

  4. None of the above


Correct Option: B
Explanation:

When a man with blood group "AB" marries a woman with "0" blood group then blood group of children will be A' orB' which is differ from parental blood group. 

Parents belong to blood group A and B. Blood group of their child would be

  1. A or B

  2. O

  3. AB

  4. All the above.


Correct Option: D

A child of blood group O cannot have parents of blood groups

  1. AB and AB/O

  2. A and B

  3. B and B

  4. O and O.


Correct Option: A

Blood transfusion is possible between groups

  1. Donor A and recipient O

  2. Donor B and recipient A

  3. Donor AB and recipient O

  4. Donor AB and recipient AB


Correct Option: D

What cannot be the blood groups of the parents of a baby having blood group A?

  1. O and O

  2. O and A

  3. A and O

  4. A and A.


Correct Option: A

A woman with blood group O marries a man of AB blood group. The blood group of their child would be

  1. AB and O

  2. A or B

  3. AB

  4. O.


Correct Option: B

Which of the following genotypes have blood group B?

  1. A/B, +/+

  2. A/A, +/A

  3. +/+, +/+

  4. B/B, +/B.


Correct Option: D

O blood group is universal donor because the blood has

  1. Antigen A

  2. Antigen B

  3. Both antigens A and B

  4. No antigens.


Correct Option: D

A blood group does not have any antigen but possesses both a and b antibodies. It is

  1. A

  2. O

  3. B

  4. AB.


Correct Option: B

Blood group A has

  1. Antibody a on RBC

  2. Antibody a in plasma

  3. Antigen A on RBC

  4. Antigen A in plasma.


Correct Option: C

A child has blood group B. Mother has blood group A. The blood group of the father would be

  1. O

  2. O or A

  3. B or AB

  4. A.


Correct Option: C

In ABO system of blood grouping, transfusion is not possible from

  1. A to AB

  2. B to AB

  3. O to AB

  4. A to O.


Correct Option: D

The genotype of B-group father of an O-group child is

  1. $I^O I^O$

  2. $I^B I^B$

  3. $I^A I^B$

  4. $I^O I^B$.


Correct Option: D

Which of the following chemicals can be used as anticoagulant?

  1. Sodium chloride

  2. Sodium citrate

  3. Sodium nitrate

  4. Ammonium chloride.


Correct Option: B

Husband and wife should know their Rh factors because the situation can be serious due to biological incompatibility in one of the following cases

  1. $Rh^+$ husband and $Rh^+$ wife

  2. $Rh^-$ husband and $Rh^-$ wife

  3. $Rh^-$ husband and $Rh^+$ wife

  4. $Rh^+$ husband and $Rh^-$ wife.


Correct Option: D

In case of emergency (e.g., serious accident with great blood loss) which blood group could be safely transfused

  1. AB $Rh^-$

  2. O $Rh^+$

  3. AB $Rh^+$

  4. O $Rh^-$.


Correct Option: D

A man with blood group A marries AB blood group woman. Which type of progeny indicate that the man is not homozygous?

  1. AB

  2. B

  3. A

  4. O.


Correct Option: B

Person with AB blood group can

  1. Not receive universally

  2. Universally donate

  3. Universally receive

  4. Receive only from O.


Correct Option: C

Parents with blood groups O and AB cannot have AB child as

  1. Gene for O is dominant over gene for B

  2. Gene for O is dominant over gene for A

  3. Genes for A and B are absent in one of the parents

  4. Gene for A or B is absent in one of the parents.


Correct Option: C

Which one is the common anticoagulant used for preserving blood?

  1. Sodium hydroxide

  2. Sodium chloride

  3. Sodium oxalate

  4. Sodium bicarbonate.


Correct Option: C

Donor X and recipient Y belong to same blood group. Transfusion has led to RBC agglutination because

  1. X is $Rh^+$, Y is $Rh^-$

  2. X is $Rh^-$, Y is $Rh^+$

  3. Both are $Rh^+$

  4. Both are $Rh^-$.


Correct Option: A

$Rh^-$ mother carries $Rh^+$ foetus. The foetus is at risk of disease called

  1. Haemophilia

  2. Haemolytic disease

  3. Tuberculosis

  4. Syphilis.


Correct Option: B

Rh factor occurs in

  1. All reptiles

  2. Man and Rhesus Monkey

  3. All mammals

  4. All vertebrates.


Correct Option: B

A sample of blood shows clumping with antiserum A but not with antiserum B. The blood group would be

  1. O

  2. A

  3. B

  4. AB.


Correct Option: B

Blood group B means the person

  1. Can form antibody for B

  2. Cannot form antibody for B

  3. Can receive blood of AB group

  4. Cannot receive blood group O.


Correct Option: B

Problem related to Rh factor arias when $Rh^+$ and $Rh^-$ bloods mix up

  1. In test tube

  2. Through transfusion

  3. Through pregnancy

  4. Both A and C.


Correct Option: B

Person with AB blood group can receive blood from

  1. AB only

  2. O only

  3. Both A and B

  4. All the above.


Correct Option: D

In which of the following situations, there is risk of erythroblastosis foetalis

  1. Mother $Rh^+$, father $Rh^+$

  2. Mother $Rh^-$, father $Rh^-$

  3. Mother $Rh^-$, father $Rh^+$

  4. Mother $Rh^+$, father $Rh^-$.


Correct Option: C

Which one is not a blood group

  1. ABO and Rh

  2. Rh and MN

  3. Buffs and Kips

  4. Lewis and Duffy.


Correct Option: C

Blood corpuscles containing both A and B antigens are mixed with another blood serum. The blood corpuscles agglutinated. Blood serum belongs to blood group

  1. A

  2. B

  3. AB

  4. O.


Correct Option: D

For safe blood transfusion

  1. Donor's RBC should not contain antibodies against recipient's serum

  2. Recipient's serum should not contain antigens against donor's antibodies

  3. Recipient's serum should not contain antibodies against RBC of donors

  4. Recipient's RBC should not contain antibodies against donor's antigens.


Correct Option: C

A mismatch during transfusion of blood causes

  1. Agglutination

  2. Erythroblastosis

  3. Haemopoies

  4. None of the above.


Correct Option: A

Assertion. Blood group 'O' has both anti-A and anti-B antibodies
Reason. It does not have any antigen

  1. A

  2. B

  3. C

  4. D.


Correct Option: B

Rh factor occurs in

  1. All vertebrates

  2. All reptiles

  3. All mammals

  4. Man and Rhesus monkey only.


Correct Option: D

Which blood transfusion is correct?

  1. A $\rightarrow$ B

  2. B $\rightarrow$ A

  3. AB $\rightarrow$ A

  4. O $\rightarrow$ B.


Correct Option: D

Blood group agglutinogen is

  1. Phosphoprotein

  2. Glycoprotein

  3. Haemoprotein

  4. Phospholipid.


Correct Option: B

Haemolytic disease of new born due to Rh incompatibility is

  1. Erythroblastosis foetalis

  2. Hydrops foetalis

  3. Kernicterus

  4. All the above.


Correct Option: A

If the foetus is Rh (+) ve and the mother is Rh (-) ve, then

  1. Foetus will transmit blood toxin to mother

  2. Foetus will transmit antibody to mother's blood

  3. Foetus is attacked by antibodies of mother's blood

  4. Foetus is attacked by antigen of mother's blood


Correct Option: C

What is true of blood group B

  1. The person can form antibody b

  2. The person cannot form antibody b

  3. The person cannot be given blood of 'O' group

  4. The person can receive blood of AB group.


Correct Option: B

The natural antibodies in the plasma of a person with blood group 'O' is

  1. anti-A

  2. anti-B

  3. anti-A and anti-B

  4. anti-B and anti-D

  5. anti-D.


Correct Option: C

Clumping of RBC may occur when blood of one person is mixed with serum or blood of another person. This is due to

  1. Antigen-antibody reaction

  2. Antitoxin-antibody reaction

  3. Antigen-antigen reaction

  4. Antibody-antibody reaction


Correct Option: A
Explanation:

The RBC membrane contains either antigen A or antigen B, or both Antigen A and B or no antigen at all, accordingly the blood is classified as blood group A , B , AB and O respectively. The blood plasma of blood group A will have antibodies for B, that of B will have antibodies for A,  that of AB will have non, while that of O will have both the antibodies. If blood is transfused at random this will lead to antigen-antibody reaction - like if A is the blood group of the recipient while the blood group of the donor happens to be B, this will lead to clumping of the RBCs.

So, the correct answer is 'Antigen-antibody reaction'

Anti-A and Anti-B antibodies are not found in which of the following blood group?

  1. AB

  2. A

  3. O

  4. B


Correct Option: A
Explanation:

The cell membrane of RBCs in AB blood group contain both antigen A as well as antigen B therefore the blood plasma does not contain antibody A and Antibody B, to prevent the coagulation of blood cells due to antigen-antibody reactions.

So, the correct answer is 'AB'

A boy has the blood group 0. What is true of the inheritance of this blood group in his case?

  1. His mother should be with AB blood group

  2. Both his parents could be heterozygous A group

  3. His father could be homozygous B group

  4. His mother could be homozygous A group


Correct Option: B
Explanation:

If the boy has blood group o, both his parents could probably be heterozygous A group, $I^AI^O$, in both the parents.

So, the correct option is 'Both his parents could be heterozygous A group'.

Rh factor was discovered by

  1. Landsteiner and Weiner

  2. William Harvey

  3. Malpighi

  4. None of these


Correct Option: A
Explanation:

Rh factor is an independent antigen present on the RBC irrespective of the presence of Antigen A or B. This factor is passed down from genus Rhesus macaque  (monkey) to humans and is regarded as the Rh factor it was discovered by Landsteiner and Weiner.

so, the correct answer is 'Landsteiner and Weiner'

Genotype of human blood group 'O' will be ______________.

  1. $I^A I^A$

  2. $I^A I^B$

  3. ii

  4. $I^A i$


Correct Option: A

A child's blood group is `O'. The parents blood groups cannot be

  1. AB and 0

  2. B and 0

  3. A and B

  4. A and A


Correct Option: A

A woman of blood group O' presented a baby of blood groupO' which she claimed as her child. She brought a suit against a man of 'AB' group as the father of the child. 

Which statement is correct as per your judgement

  1. The father and mother claimed are the true persons

  2. Father is true and mother is not the true person

  3. Both the parentage claims are false

  4. Mother is the true person and father claimed is not true


Correct Option: D

Antigen - A andantibody - B are present in which blood group

  1. B

  2. A

  3. AB

  4. 0


Correct Option: B

In a medico-legal case of accidental interchange between two babies in a hospital, the baby of blood group A could not be rightly given to a people

  1. With both husband and wife of group 0

  2. Husband of group 0 and wife of group A

  3. Husband of group A and wife of group 0

  4. Both husband and wife of group A


Correct Option: A

Which blood group called as universal donar?

  1. $AB$

  2. $A$

  3. $B$

  4. $O$


Correct Option: D
Explanation:

Type O ( specifically O negative ) blood is called the universal donor type because it is compatible with any blood type. O blood group does not contain any antigen hence does not result in transfusion reactions.


So, the correct option is 'O'.

If the mother is $Rh^{-ve}$ and father is $Rh^{+ve}$, which of the following $Rh^{+ve}$ child is normally not affected?

  1. First

  2. Second

  3. Male child

  4. Female child


Correct Option: A
Explanation:

Rh incompatibility usually isn't a problem if it's the mother's first pregnancy because, unless there's some sort of abnormality, the fetus's blood does not normally enter the mother's circulatory system during the course of the pregnancy. However, during second child, the mother's and baby's blood can intermingle. If this happens, the mother's body recognizes the Rh protein as a foreign substance and might begin making antibodies (protein molecules in the immune system that recognize, and later work to destroy foreign substances) against the Rh proteins. Rh antibodies are harmless until the mother's second or later pregnancies. If she is ever carrying another Rh-positive child, her Rh antibodies will recognize the Rh proteins on the surface of the baby's blood cells as foreign, and pass into the baby's bloodstream and attack those cells. This can lead to swelling and rupture of the baby's RBCs. A baby's blood count can get dangerously low when this condition, known as a haemolytic or Rh disease of the newborn, happens.

Therefore, the correct answer is option B.

Which one of the following couple were suggested by doctors to not have more than one child?

  1. Rh$^+$ male and Rh$^-$ female

  2. Rh$^-$ male and Rh$^+$ female

  3. Rh$^+$ male and Rh$^+$ female

  4. Rh$^-$ male and Rh$^-$ female


Correct Option: A
Explanation:
Rh incompatibility occurs when a Rh- negative mother is impregnated by a Rh- positive father. The result can be Rh- positive baby. In such a case, the baby’s Rh antigens will be recognized as foreign invaders. The mother’s blood cells attack the baby’s as a protective mechanism and can cause erythroblastosis fetalis. If the mother is pregnant with her first baby, Rh incompatibility is not as much of a concern. However, when the Rh- positive child is born, the mother’s body creates antibodies against the Rh factor, which will attack the blood cells if she becomes pregnant with another Rh- positive baby.
Hence, the correct answer is option A.

Biological marriage of one of the following should be avoided
                                                 or

After examining the blood groups of a couple, the doctor advised them not to have more than one child. The blood group of the couple are likely to be

                                                or

In which of the following situations, is there a risk factor for children of incurring erythroblastosis foetalis

  1. Rh+ male and Rh- female

  2. Rh+ male and Rh+ female

  3. Rh- male and Rh+ female

  4. Rh- male and Rh- female


Correct Option: A

The problem of erythroblastosis foetalis occurs when 

  1. Both father and mother are Rh positive

  2. Both father and mother are Rh negative

  3. Mother is Rh positive and father is Rh negative

  4. Father is Rh positive and mother is Rh negative


Correct Option: D
Explanation:

If a woman who is Rh- negative married to a man who is Rh- positive produces a baby may have Rh- positive blood, inherited from the father. Rh antibodies are harmless until the mother's second or later pregnancies. If she is ever carrying another Rh- positive child, her Rh antibodies will recognize the Rh proteins on the surface of the baby's blood cells as foreign and attack those cells. This can lead to rupture of the baby's RBCs known as haemolytic or Rh disease of the newborn or erythroblastosis foetalis. 

Therefore, the correct answer is option D.

Name of the disease due to Rh factor.

  1. Accquired Immuno Deficiency Syndrome

  2. Turner's Syndrome

  3. Erythroblastosis foetalis

  4. Sickle - cell anaemia


Correct Option: C
Explanation:

When a woman is pregnant having Rh negative blood group and the blood group of the foetus is Rh positive, then her baby's blood type will be incompatible with her own. This can cause a condition known as erythroblastosis fetalis, where the mother's red blood cells attack those of the baby as there would any foreign invaders. Rh incompatibility and ABO incompatibility are the two main cause. Both are associated with blood type. Thus, the correct answer is option C.

A doctor suggested to a couple not to have more than one child because of

  1. $Rh^+$ male and $Rh^-$ female

  2. $Rh^-$ male and $Rh^+$ female

  3. $Rh^+$ male and $Rh^+$ female

  4. $Rh^-$ male and $Rh^-$ female.


Correct Option: A

Chances of erythroblastosis foetalis occurring during second pregnancy when the baby is

  1. $Rh^+$ and mother $Rh^-$

  2. $Rh^+$ and mother $Rh^+$

  3. $Rh^-$ and mother is $Rh^+$

  4. $Rh^-$ and mother $Rh^-$.


Correct Option: A

If a women becomes pregnant second time, the foetus is in danger when

  1. Mother is Rh (+) ve and foetus is Rh (-) ve

  2. Mother is Rh (-) ve and foetus is Rh (+) ve

  3. Father is Rh (-) ve and foetus is Rh (+) ve

  4. Father is Rh (+) ve and foetus is Rh (-) ve.


Correct Option: B

The problem due to Rh factor arises when the two blood (Rh${^+}$ and Rh${^-}$ ) mix up

  1. In a test tube

  2. Through transfusion

  3. During pregnancy

  4. All of the above


Correct Option: D
Explanation:

Rh incompatibility arises when mother and the baby carries different protein factors. The problem arises when mother is Rh negative and the child she is carrying is Rh positive. This can take place even when two blood groups with different proteins are either mixed in a test tube or transfused into a person. Rh negative people do not have this protein and if Rh positive blood is mixed with Rh negative blood anti Rh antibodies develop which can lead to problems. 

In erythroblastosis foetalis, which factors of the mother pass through placenta into the fetus?

  1. Rh antigens

  2. Rh antibodies

  3. ABO antibodies

  4. Agglutinins


Correct Option: B
Explanation:

Erythroblastosis fetalis also called the hemolytic disease of the newborn, type of anemia in which the red blood cells (erythrocytes) of a fetus are destroyed in a maternal immune reaction resulting from a blood group incompatibility between the fetus and its mother. Symptoms of erythroblastosis fetalis range from mild to severe; death of the fetus or newborn sometimes results.

The Rh system is responsible for the most severe form of the disease, which can occur when a Rh-negative woman (a woman whose blood cells lack the Rh factor) conceives a Rh-positive fetus. Sensitization of the mother’s immune system (immunization) occurs when fetal red blood cells that carry the Rh factor (an antigen in this context) cross the placental barrier and enter the mother’s bloodstream. They stimulate the production of antibodies, some of which pass across the placenta into fetal circulation and lyse, or break apart, the red blood cells of the fetus (hemolysis). Hence option B is correct.

Erythroblastosis foetalis is caused when fertilisation takes place between gametes of

  1. $Rh^-$ female and $Rh^+$ male.

  2. $Rh^+$ female and $Rh^-$ male.

  3. $Rh^+$ female and $Rh^+$ male.

  4. $Rh^-$ female and $Rh^-$ male.


Correct Option: A
Explanation:
 Erythroblastosis foetalis is caused by transplacental transmission of maternal antibodies to foetal RBCs when  mother is Rh- and the foetus is Rh+.
So, the correct option is 'Rh- female and Rh+ male'

In which of the following situations, there is a risk factor for children acquiring erythroblastosis foetalis?

  1. Mother is Rh -ve and father is Rh -ve.

  2. Mother is Rh -ve and father is Rh +ve.

  3. Mother is Rh +ve and father is Rh +ve.

  4. Mother is Rh +ve and father is Rh -ve.


Correct Option: B
Explanation:
Erythroblastosis fetalis also called hemolytic disease of the newborn, type of anemia in which the red blood cells (erythrocytes) of a fetus are destroyed in a maternal immune reaction resulting from a blood group incompatibility between the fetus and its mother. This happens during second pregnancy when the mother's immune system is already sensitized to Rh$^+$ antigens present on the blood cells of the foetus during the first pregnancy. The Rh gene being dominant, the feotus will be Rh$^+$ if anyone of the parent is Rh$^+$.
 So, the correct answer is "Mother is Rh-ve and father is Rh+ve."

In which of the following situations, is there a risk factor for children of incurring erythroblastosis foetalis?

  1. Mother is Rh -ve and father is Rh -ve.

  2. Mother is Rh -ve and father is Rh +ve.

  3. Mother is Rh +ve and father is Rh +ve.

  4. Mother is Rh +ve and father is Rh -ve.


Correct Option: B
Explanation:

There are two main causes of erythroblastosis fetalis: Rh incompatibility and ABO incompatibility. Rh incompatibility occurs when a Rh-negative mother is impregnated by a Rh-positive father. The result can be a Rh-positive baby. In such a case, your baby’s Rh antigens will be perceived as foreign invaders, the way viruses or bacteria are perceived. Your blood cells attack the baby’s as a protective mechanism that can end up harming the child. If you’re pregnant with your first baby, Rh incompatibility isn’t as much of a concern. However, when the Rh-positive child is born, your body will create antibodies against the Rh factor. These antibodies will attack the blood cells if you ever become pregnant with another Rh-positive baby.


So, the correct option is 'Option B'.

Rh factor may be responsible for

  1. Turner's syndrome

  2. Accquired Immuno Deficiency Syndrome

  3. Sickle cell anaemia

  4. Erythroblastosis foetalis


Correct Option: D
Explanation:

Erythroblastosis foetalis is a disease of the new born which is caused by Rh incompatibilty. This happens when mother is Rh negative and the child she is bearing is Rh positive. Thus the Rh antigen of child can trigger the antibodies inside mother which can travel through circulation thus destroying foetus blood cells. Thus, correct answer is option D.

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