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Vaccination - class-XII

Description: vaccination
Number of Questions: 45
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Tags: zoology biology cell biology and biotechnology human health and diseases immune system
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Vaccines prepared through recombinant DNA technology are called

  1. First generation vaccines

  2. Second generation vaccines

  3. Third generation vaccines

  4. None of these


Correct Option: C
Explanation:

The first generation vaccines consist of live attenuated/ heat killed vaccines in which whole organisms in the weakened live form or heat killed form are injected. Sevcond generation vaccines are those vaccines in which the whole organism is not given. Instead of this a portion called the subunit, which may contain a protein section of the pathogen is given. Third generation vaccines are those in which recombinant techniques are used for the production of vaccines. In this technique DNA encoding the antigen is inserted into a vector which will be recognised as a pathogen in the host. Such that the host immune system generates an immune response against the vector and thereby the antigen. So, the correct answer is 'Third generation vaccines'.

T.T. and TAB second booster dose is given at the age of?

  1. $2-3$ years

  2. $4-6$ years

  3. $10$th year

  4. $16$th year


Correct Option: A

Hepatitis - B vaccine is 

  1. First generation vaccine

  2. Second generation vaccine

  3. Third generation vaccine

  4. Fourth generation vaccine


Correct Option: B
Explanation:

They are three types of vaccines on basis of organism or its part used as antigen.

First generation :They are live/ attenuated pathogen(inactivated)or heat killed pathogen is used.As in BCG vaccine.
Second generation :They are prepared by genetic engineering which contain subsection as protein form or toxoids in case of bacteria.As in hepatitis B vaccine.
Third generation :They are artificially synthesized .It can be recombinant vector vaccines where antigen is a sub-unit of the pathogen and is integrated into another virus against which we have been known to mount  a decent response and then such virus multiplies in a bacteria.As in Ebola vaccine.Hence hepatitis-B vaccine is a second generation vaccine.
So, the correct answer is "second generation vaccine". 

The letter B in the name BCG vaccination stands for

  1. Brief

  2. Ben-ben

  3. Bacteria

  4. Bacillus


Correct Option: D
Explanation:
BCG  vaccine stands for Bacillus Calmette–Guérin vaccine. The letter B in the name BCG vaccination stands for bacillus. BCG vaccine is a vaccine primarily used against tuberculosis(TB). BCG vaccine can be administered after birth intradermally.
So, the correct answer is 'Bacillus'.

Vaccination against smallpox means the introduction into our body of

  1. Leucocytes obtained from an animal

  2. Antibodies produced in other animals

  3. Antibodies

  4. Actual weakened germs or attenuated smallpox virus


Correct Option: D
Explanation:

Smallpox vaccine is produced from the artificially attenuated smallpox virus. The administration of this vaccine ios called as vaccination against smallpox. As on administration of this vaccine, our body develops immunity against the particular virus.

Thus, the correct answer is option D.

The most modern technique of vaccine preparation is

  1. Extraction of antigens from pathogens

  2. Multiplication of antigens through DNA technique

  3. Weakening of pathogen through chemical treatment

  4. Attenuation of pathogen through heat


Correct Option: B

Hepatitis B vaccine is

  1. Combined vaccine

  2. Recombinant antigen vaccine

  3. Polysaccharide vaccine

  4. DNA vaccine


Correct Option: B
Explanation:
  • Hepatitis B vaccine is a vaccine that prevents hepatitis B.
  •  The first dose is recommended within 24 hours of birth with either two or three more doses given after that. 
  • The vaccine is given by injection into a muscle. Serious side effects of the hepatitis B vaccine are very uncommon. Pain may occur at the site of injection.
  •  The current vaccines are produced with recombinant DNA techniques.
  • Hence, the Hepatitis B vaccine is Recombinant antigen vaccine.
  •   So, the correct answer is 'Recombinant antigen vaccine'.

BCG vaccine is given to prevent

  1. Tuberculosis

  2. Leprosy

  3. Food poisoning

  4. None of the above


Correct Option: A
Explanation:

BCG stands for Bacillus Calmette Guerin, a vaccine given for protection against tuberculosis (T.B.) which is an airborne disease, caused by Mycobacterium tuberculosis.

So, the correct answer is option A.

Mark the correct options

  1. The varicella vaccine has resulted in a decrease in the number of cases and complication from the disease

  2. It protects about $70$ to $90$ percent of people from disease with a greater benefit for severe disease

  3. Routine immunization of children is recommended in many countries

  4. All of the above


Correct Option: D
Explanation:

The varicella vaccine has resulted in a decrease in the number of cases and complications from the disease. It protects about 70 to 90 percent of people from disease with a greater benefit for severe disease. Routine immunization of children is recommended in many countries. Immunization within three days of exposure may improve outcomes in children. Treatment of those infected may include calamine lotion to help with itching, keeping the fingernails short to decrease injury from scratching, and the use of paracetamol (acetaminophen) to help with fevers.

So, the correct answer is 'All of the above'

What is induced in (polio) vaccination?

  1. Antibodies

  2. Antigen

  3. Antibiotics

  4. None of the above


Correct Option: B
Explanation:

Polio vaccines are vaccines used to prevent poliomyelitis (polio). Two types are used - an inactivated poliovirus (antigen) given by injection and a weakened poliovirus (antigen) given by mouth. The inactivated polio vaccines are very safe. Mild redness or pain may occur at the site of injection. Oral polio vaccines cause vaccine-associated paralytic poliomyelitis.

So, the correct answer is 'Antigen'.

DPT vaccine acts against

  1. Diphtheria, Wooping cough, Tetanus

  2. Diarrhoea, Polio, Tetanus

  3. Diphtheria, Polio, Tetanus

  4. Diarrhoea, Whooping cough, Tetanus


Correct Option: A
Explanation:

DPT (also DTP and DTwP) is a class of combination vaccines against three infectious diseases in humans: diphtheria, pertussis (whooping cough), and tetanus. The vaccine components include diphtheria and tetanus toxoids and killed whole cells of the bacterium that causes pertussis (wP). So, the correct option is "A" (Diphtheria, Wooping cough, Tetanus).

First DPT does be given when the baby is?

  1. Six weeks old

  2. Fourteen weeks old

  3. Nine months old

  4. $2-5$ years old


Correct Option: A

The vaccine of Hepatitis-B is a

  1. First generation vaccine

  2. Interferon

  3. Second generation vaccine

  4. Third gereration vaccine


Correct Option: C
Explanation:

Second generation vaccines were developed to reduce the risks from live vaccines. These are subunit vaccines, consisting of defined protein antigen like tetanus or diphtheria toxoid or recombinant protein components like hepatitis B surface antigen.
Therefore, the correct answer is option C.

BCG Stand for

  1. Bacterial cell genome

  2. Bacillus Calmette Guerin

  3. Bacteria culture growth

  4. None of the above


Correct Option: B
Explanation:

BCG stands for Bacillus Calmette Guerin, a vaccine given for protection against tuberculosis which is an airborne disease, caused by Mycobacterium tuberculosis.  

Thus, the correct answer is option B. 

Oral vaccine is given for

  1. Polio

  2. Smallpox

  3. Diphtheria

  4. Tetanus


Correct Option: A
Explanation:

The oral polio vaccine (OPV) was developed in 1961 by Albert Sabin. OPV consists of a mixture of live, attenuated (weakened) polio virus strains of all three polio virus types. Rotavirus liquid vaccines are also given by mouth (orally) to infants.

The vaccine triple antigen is given to children to protect them against

  1. Tetanus, Diphtheria and Whooping cough

  2. Polio, Tuberculosis and Diphtheria

  3. Diphtheria, Polio and Tetanus

  4. None of the above


Correct Option: A
Explanation:

Triple antigen vaccine is a combination of diphtheria, tetanus and pertussis (or whooping cough). The vaccine stimulates the production of antibodies to immunize the body against the causative agents of the three viruses.

DTP vaccine is given to infants to immunize them against

  1. Diptheria, pneumonia and typhoid

  2. Diphtheria, whooping cough and tetanus

  3. Diarrhoea, pneumonia and tuberculosis

  4. Diptheria, whooping cough and typhoid


Correct Option: B
Explanation:

DPT (also DTP and DTwP) refers to a class of combination vaccines against three infectious diseases in humans diphtheria, pertussis (whooping cough), and tetanus. The vaccine components include diphtheria and tetanus toxoids and killed whole cells of the organism that causes pertussis (wP). 

BCG vaccine contains

  1. Live but attenuated bacteria

  2. Killed bacteria

  3. Toxoids against TB-bacteria

  4. Antibodies against bacteria


Correct Option: A
Explanation:

The BCG vaccine contains a live but weakened form of a type of bacteria called Mycobacterium bovis which causes tuberculosis (TB) in cattle. The bacteria are altered so that they do not cause a TB infection, but stimulate the immune system to make resistant to the disease. The vaccine is known as BCG because a strain of the bacterium known as Bacillus Calmette-Guerin is used. 

DPT is administered to prevent

  1. Diphtheria

  2. Pertussis

  3. Tetanus

  4. All of the above


Correct Option: D
Explanation:

DPT (also DTP and DTwP) refers to a class of combination vaccines against three infectious diseases in humans: diphtheria, pertussis (whooping cough), and tetanus. The vaccine components include diphtheria and tetanus toxoids and killed whole cells of the organism that causes pertussis (wP).

DPT vaccine is given to infants to immunize them against 

  1. Diphtheria, pneumonia and typhoid

  2. Diphtheria, whooping cough and tetanus

  3. Diarrhoea, pneumonia and tuberculosis

  4. Diphtheria, whooping cough and typhoid


Correct Option: B
Explanation:

DPT (also DTP and DTwP) refers to a class of combination vaccines against three infectious diseases in humans: diphtheria, pertussis (whooping cough), and tetanus. The vaccine components include diphtheria and tetanus toxoids and killed whole cells of the organism that causes pertussis (wP).

Therefore, the correct answer is option B.

The vaccine triple antigen is given to children to protect them against diphtheria

  1. Polio and Tetanus

  2. Whooping cough and Tetanus

  3. Whooping cough and Tuberculosis

  4. Polio and Tuberculosis


Correct Option: B
Explanation:
DTP is a triple antigen vaccine is meant to protect against 3 diseases – diphtheria, tetanus and pertussis (or whooping cough). The DTPa (DPaT) is given as part of the childhood vaccination schedule at 2, 4 and 6 months of age, then again at 4 years of age.

DTP vaccine is given to protect the diseases like

  1. Diphtheria, polio and tuberculosis

  2. Diphtheria, whooping cough, tetanus

  3. Diarrhoea, polio, tetanus

  4. Diarrhoea, pertussis, tuberculosis


Correct Option: B
Explanation:
DPT (also DTP and DTwP) refers to a class of combination vaccines against three infectious diseases in humans: diphtheria, pertussis (whooping cough), and tetanus. The vaccine components include diphtheria and tetanus toxoids and killed whole cells of the organism that causes pertussis (wP).
Therefore, the correct answer is option B.

In vaccination

  1. Globular proteins with live disease causing germ is injected

  2. A weakened or dead disease causing germ is administered in small doses

  3. General and local anaesthetics are applied to the patient

  4. Affected part of the human body is amputed


Correct Option: B
Explanation:
Vaccines cause the body to build immunity against infectious diseases without causing the actual disease. Vaccines can be made by weakened or dead disease causing microorganisms like bacteria or virus. The administration of small dose of vaccine causes the formation antibodies which provides immunity. 
Therefore, the correct answer is option B.

The vaccines contains:


a) Derivatives of microbes
b) Dead or weakened microbes
c) Products of microbes

  1. a, b

  2. b, c

  3. c, d

  4. All of the above


Correct Option: D
Explanation:

Vaccines are suspensions of killed or weakened microbes or products or derivatives of micro organisms. A vaccine produces immunity to a disease by stimulating the production of antibodies.

First triple antigen vaccination is given to the child after............ of birth

  1. One Week

  2. Two months

  3. Four months

  4. One year


Correct Option: B
Explanation:

The triple antigen vaccine is a combination of Diphtheria, Tentanus and Pertussis (DTP). This vaccine is given at the age of two months and is repeated at the age of 4 months and 6 months.
Thus, the correct answer is option B.

DPT gives protection against 

  1. Diphtheria, Polio and Tuberculosis

  2. Diphtheria, Pertussis and Tetanus

  3. Diarrhoeal diseases, Pertussis and Tetanus

  4. Diphtheria, Poliomyelitis and Tetanus


Correct Option: B
Explanation:

DPT is a class of combination vaccines which provides protection against three infectious diseases in humans i.e., diphtheria, pertussis (whooping cough), and tetanus. The components of the vaccine include diphtheria and tetanus toxoids and kill whole cells of the bacterium that causes pertussis. The usual course of childhood immunization in the USA is five doses between 2 months and 15 years. 

So, the correct answer is 'Diptheria, Pertussis and Tetanus'.

DPT-Hib (DTP-Hib) vaccination is agent

  1. Diphtheria, Tetanus, Pertussis and Hepatitis-B

  2. Diphtheria, Tetanus, Pertussis and Hepatitis-A

  3. Diphtheria, Tetanus, Pertussis and Haemophilus influenzae-B

  4. Diphtheria, Tetanus, Pertussis and Haemophilus influenzae-A


Correct Option: C
Explanation:

DPT-Hib vaccine is a combination vaccine which includes diphtheria and tetanus toxoids and whole-cell pertussis vaccine adsorbed with Hib (Haemophilus influenza - B) conjugate vaccine. It protects against the infectious diseases diphtheria, tetanus, pertussis, and Haemophilus influenza type B.

So, the correct answer is 'Diptheria, Tetanus, Pertussis and Haemophilus influenza-B'.

Which of the following diseases is not treated by inactivated 'Whole Agent Vaccine'?

  1. Hepatitis-A

  2. Bubonic plague

  3. Cholera

  4. Typhoid


Correct Option: D
Explanation:
  • In 1896, heat-killed phenol preserved and acetone killed lyophilized injectable whole cell S. Typhi vaccine was generated. 
  • This inactivated whole-cell vaccine causes local inflammation, pain, systemic fever, malaise and disease-like symptoms.  
  • Thus, the whole cell inactivated vaccine was not considered suitable for public use and in spite of being licensed it is no longer available in the market. 
  • Most commonly used antibiotics for the treatment of typhoid fever are fluoroquinolones such as ciprofloxacin, ofloxacin and pefloxacin and third-generation cephalosporins such as ceftriaxone or cefotaxime. 
  • Hence, Typhoid is not treated by inactivated Whole Agent Vaccine.
  •  So, the correct answer is 'Typhoid'.

Match the type of antigen given in Column I with the example given in Column II of vaccine.

Column I Column II
a. Live attenuated (i) Salk polio vaccine
b. Killed microbes (ii) Tetanus vaccine
c. Toxoid (iii) Hepatitis 'B' vaccine
d. Antigen polypeptides synthesised by genetic engineering (iv) MMR vaccine
  1. a(ii), b(iii), c(i), d(iv)

  2. a(ii), b(i), c(iii), d(iv)

  3. a(iv), b(i), c(ii), d(iii)

  4. a(iv), b(ii), c(i), d(iii)


Correct Option: A

Antivenom injection contains preformed antibodies while polio drops that are administered into the body contain

  1. Attenuated pathogens

  2. Activated pathogens

  3. Harvested antibodies

  4. Gamma globulin


Correct Option: A
Explanation:

  • Antivenom injection is an antiserum (preformed antibodies) which is obtained from the snake poison and it is transferred to the person with a snake bite. It is used to provide immediate immunity in case of emergency.
  • Polio vaccines are vaccines used to prevent poliomyelitis (polio). Two types are used - an inactivated poliovirus (antigen) given by injection and an attenuated poliovirus (antigen) given by mouth. The inactivated polio vaccines are very safe. Mild redness or pain may occur at the site of injection. Oral polio vaccines cause vaccine-associated paralytic poliomyelitis.
So, the correct answer is 'Attenuated pathogens'.

Suspension of attenuated pathogen that stimulates antibody formation is

  1. Antitoxin

  2. Antibiotic

  3. Vaccine

  4. Sera


Correct Option: C
Explanation:

A vaccine is a biological preparation that provides active acquired immunity to a particular disease. A vaccine typically contains a suspension of disease-causing microorganism and is often made from weakened (attenuated) or killed forms of the microbe, its toxins, or one of its surface proteins.  The agent stimulates the body's immune system and produces antibodies.

So, the correct answer is 'Vaccine'.

Which one of the following cannot be used for preparation of vaccination against plague?

  1. Heat killed suspension of virulent bacteria

  2. Formaline inactivated suspension of virulent bacteria

  3. A virulent live bacteria

  4. Synthetic capsular polysaccharide material


Correct Option: D
Explanation:

  • Plague is an infectious disease caused by the bacterium Yersinia pestis.
  •  Killed bacteria have been used since 1890 but are less effective against pneumonic plague so that recently live vaccines of an attenuated type and recombination protein vaccines have been developed to prevent the disease.
  • Synthetic capsular polysaccharide vaccines are used for the treatment of pneumonia and meningitis. 
  • Hence, Synthetic capsular polysaccharide material cannot be used for the preparation of vaccination against the plague. 
  • So, the correct answer is 'Synthetic capsular polysaccharide material'.

What is introduced in the body during small pox vaccination?

  1. Antibodies

  2. leucocytes

  3. Antibiotics

  4. Attenuated virus


Correct Option: D
Explanation:

Smallpox is a serious viral disorder caused by the variola virus. Variola virus is an orthopoxvirus, an enveloped DNA virus. The infection starts by exposure of the virus in the nasopharynx and characterized by fever and malaise. 

A vaccine is prepared from the killed and weakened form of a pathogen that is similar to the disease-causing agent. This vaccine is injected into an individual to induce the immune system against the microbes. The vaccine for smallpox is prepared from a weakened form of variola virus. Thus, during smallpox vaccination attenuated virus is introduced in the body that induces immunity against the infection.

Match the list and find the correct answer.

   LIST I   LIST II 
 a  Conjugate vaccine  Human papilloma virus
 b  Toxoid vaccine ii   Haemophilus influenzae
 c  Attenuated whole agent vaccine  iii   Bubonic plague
 d  Inactivated whole agent vaccine iv   Yellow fever
     v  Diphtheria
  1. a - i, b - iv, c - v, d - ii

  2. a - ii, b - v, c - iv, d - iii

  3. a - i, b - ii, c - iii, d - v

  4. a - ii, b - iii, c - i, d - iv


Correct Option: B
Explanation:
  • Conjugate vaccines combine a weak antigen with a strong antigen so that the immune system has a stronger response to the weak antigen. Example: Haemophilus influenza.
  •  Toxoid vaccine is made from a toxin (poison) that has been made harmless but that helps in an immune response against the toxin. They are based on the toxin produced by certain bacteria (e.g. tetanus or diphtheria). An
  • The attenuated vaccine is a vaccine created by reducing the virulence of a pathogen, but still keeping it viable. Example are Measles, mumps, rubella, yellow fever. 
  • Inactivated whole-cell vaccines are made from microorganisms (viruses, bacteria, other) that have been killed through physical or chemical processes. An example is Polio, bubonic plague, Hepatitis A.

A person likely to develop tetanus is immunised by giving

  1. Weakened germs

  2. Pre-formed germs

  3. Dead grems

  4. Wide spectrum antibodies


Correct Option: B
Explanation:

Tetanus vaccine, also known as tetanus toxoid (TT), is an inactive vaccine used to prevent tetanus. A person likely to develop tetanus is immunised by giving pre-formed antibodies and it produces passive immunity. In passive immunity, the antibodies are produced in some other animals in response to given antigen. These pre-formed antibodies are then injected into the humans at the time of need or emergency.

So, the correct answer is 'Pre-formed germs'.

BCG vaccine provides protection against 

  1. Measles

  2. T.B

  3. Cholera

  4. Small pox


Correct Option: B
Explanation:
  • Tuberculosis is an infectious disease usually caused by Mycobacterium tuberculosis bacteria. Tuberculosis generally affects the lungs, but can also affect other parts of the body. The symptoms of active TB is a chronic cough with blood-containing sputum, fever, night sweats, and weight loss.

  • Bacillus Calmette–Guérin (BCG) vaccine is a vaccine primarily used against tuberculosis (TB). In most tuberculosis (TB) endemic countries, bacillus Calmette Guérin (BCG) is usually given around birth to prevent severe TB in infants.

  • Hence BCG vaccine provides protection against TB.

  • So, the correct answer is 'T B'.

The Diptheria, Pertussis, Tetanus (DPT) vaccine consists of ____________________.

  1. live attenuated strains of Diphtheria, Pertussis, Tetanus

  2. toxoid of Diptheria, Tetanus and heat killed whole cells of Pertussis

  3. whole cells lysate of Diphtheria, Pertussis, Tetanus

  4. heat killed strains of Diptheria, Pertussis, Tetanus


Correct Option: B

The vaccination against small pox means the introduction of

  1. weakened germs

  2. lymphocytes

  3. leucocytes

  4. antibodies


Correct Option: A
Explanation:

The smallpox vaccine protects people from smallpox by helping their bodies develop immunity to smallpox. The vaccine is made from a virus called vaccinia, which is a poxvirus similar to smallpox, but less harmful. The smallpox vaccine contains live vaccinia virus, not a killed or weakened virus like many other vaccines. For that reason, people who are vaccinated must take precautions when caring for the place on their arm where they were vaccinated, so they can prevent the vaccinia virus from spreading. The vaccine does not contain the smallpox virus and cannot give you smallpox. For most people with healthy immune systems, live virus vaccines are effective and safe. Smallpox vaccination can protect you from smallpox for about 3 to 5 years. After that time, its ability to protect you decreases. If you need long-term protection, you may need to get a booster vaccination. 


So, the correct option is 'Weakened germs'.

Which one of the following can not be used for preparation of vaccines against plague?

  1. Avirulent live bacteria

  2. Synthetic capsular polysaccharide material

  3. Heat-killed suspension of virulent bacteria

  4. Formalin-inactivated suspensions of virulent bacteria


Correct Option: B
Explanation:
Synthetic capsular polysaccharide vaccines are available for treatment of pneumonia and meningitis. 
Vaccines against plague are prepared from the Formalin-inactivated suspensions of virulent bacteria, Avirulent live bacteria and Heat-killed suspension of virulent bacteria
So the correct option is 'Synthetic capsular polysaccharide material'.

DTP vaccine is given to infants to immunise them against

  1. Diphtheria, pneumonia and typhoid

  2. Diphtheria, whooping cough and tetanus

  3. Diarrhoea, pneumonia and tuberculosis

  4. Diphtheria, whooping cough and typhoid


Correct Option: B
Explanation:

DPT (also DTP and DTwP) refers to a class of combination vaccines against three infectious diseases in humans diphtheria, pertussis (whooping cough), and tetanus. The vaccine components include diphtheria and tetanus toxoids and killed whole cells of the organism that causes pertussis (wP).

Therefore, the correct answer is option B.

The oral polio vaccine contains what kind of viruses ________

  1. Live viruses

  2. Killed viruses

  3. Heat killed viruses

  4. Harmful viruses


Correct Option: A
Explanation:

Explanation: The oral polio vaccine contains a live attenuated virus, that is, the live virus that is capable of multiplying but generally incapable of causing infection. The injectable polio vaccine contains the killed virus.

A disease for which vaccination is not available is

  1. Malaria

  2. Measles

  3. Cholera

  4. Tetanus


Correct Option: A
Explanation:

The complexity of the malaria parasite makes the development of a malaria vaccine a very difficult task. Vaccines are based on triggering an immune response in humans that is known to protect against an infection but there is no such response to malaria in humans.

Which of the following vaccine is contraindicated in pregnancy?

  1. Rubella

  2. OPV

  3. BCG

  4. Hepatitis


Correct Option: A
Explanation:

Measles-mumps-rubella vaccine (MMR live attenuated vaccine) is not advisable during pregnancy because there is a risk to the foetus.

What can mostly prevent the chicken pox?

  1. A pill can prevent it

  2. It cannot be prevented

  3. It can be prevented by a vaccine

  4. It is prevented by a plant


Correct Option: C
Explanation:

Explanation: Because chickenpox is airborne and is so contagious before the rash appears, it is difficult to avoid. A chickenpox vaccine is available. It is about 100 per cent effective against moderate or severe illness, and 85 or 90 per cent effective against mild chickenpox.

The absolute contraindication for administration of pertussis vaccine is

  1. Diarrhoea

  2. Fever

  3. Malnutrition

  4. Convulsions


Correct Option: D
Explanation:

after having pertussis vaccine for whooping cough, infants and children had convulsions which are the involuntary contraction of muscles.

So the correct option is D.

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