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Antacids and antihistamines - class-XII

Description: antacids and antihistamines
Number of Questions: 43
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Tags: chemistry in everyday life medicinal chemistry chemistry in daily life applied chemistry chemistry
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Which of the following will not act as antacid?

  1. Sodium hydrogencarbonate

  2. Magnesium hydroxide

  3. Sodium carbonate

  4. Aluminium carbonate


Correct Option: C
Explanation:

An antacid is a substance which neutralises stomach acidity and is used to relieve heartburn, indigestion or an upset stomach.
Antacids contain alkaline ions that chemically neutralise stomach gastric acid, reducing damage and relieving pain.
Examples of antacids are-
Sodium hydrogencarbonate,Magnesium hydroxide,Aluminium carbonate,Aluminium hydroxide.

Sodium carbonate known as washing soda is quite alkaline in nature and has a horrid soapy taste. It is not very palatable and could burn the throat. Bicarbonate is much gentler and not as strongly alkaline, and therefor more palatable. Hence, it will not act as Antacid.

The main cause of acidity in the stomach is :

  1. release of extra gastric acids which decrease the pH level

  2. indigestion and pain in large intestine

  3. increase the pH level in stomach

  4. release of extra bile juice which increases alkaline medium in stomach


Correct Option: A
Explanation:

An antacid is a substance which neutralises stomach acidity and is used to relieve heartburn, indigestion or an upset stomach.

Antacids contain alkaline ions that chemically neutralise stomach gastric acid, reducing damage and relieving pain.
Gastric acid is a digestive fluid formed in the stomach and is composed of hydrochloric acid ($HCl$), potassium chloride ($KCl$) and sodium chloride ($NaCl$). If gastric acid is released in the stomach the Ph level decreases and thereby increasing acidity in the stomach.

Which of the following statements is not correct?

  1. Some disinfectants can be used as antiseptic at low concentration.

  2. Aspirin is analgesic and antipyretic.

  3. Norethindrone is an antihistamine.

  4. Chloramphenicol is a broad spectrum antibiotic.


Correct Option: C
Explanation:
  • Same substances can act as an antiseptic as well as a disinfectant by varying the concentration. For example, 0.2 per cent solution of phenol is an antiseptic while its one per cent solution is disinfectant.
  • Aspirin acts as both analgesic and Antipyretic.
  • Antihistamines interfere with the natural action of histamine by competing with histamine for binding sites of receptor where histamine exerts its effect. Synthetic drugs, brompheniramine (Dimetapp) and terfenadine (Seldane), act as antihistamines.
  • Norethindrone is an example of a synthetic progesterone derivative most widely used as an antifertility drug.
  • Chloramphenicol is a broad spectrum antibiotic.
  • Hence, option B is not a correct statement.

The pair whose both species are used in antacid medicinal preparation is:

  1. $NaHCO _3$ nad $Mg(OH) _2$

  2. $Na _2CO _3$ and $Ca(HCO _3) _2$

  3. $Ca(HCO _3) _2$ and $Mg(OH) _2$

  4. $Ca(OH) _2$ and $NaHCO _3$


Correct Option: A
Explanation:
  • An antacid is a substance which neutralizes stomach acidity and is used to relieve heartburnindigestion or an upset stomach.
  • It is also used to relieve symptoms of extra gas such as belching, bloating, and feelings of pressure/discomfort in the stomach/gut. Aluminum and magnesium antacids work quickly to lower the acid in the stomach.
  • Generally $NaHCO _3$ and $Mg(OH) _2$ are used in antacid medicinal preparation.

Cimetidine acts as:

  1. antibiotic

  2. antifertility drug

  3. antihistamine

  4. antipyretic


Correct Option: C
Explanation:

Cimetidine is a histamine $H _2$-receptor antagonist, that inhibits stomach acid production. It is largely used in the treatment of heartburn and peptic ulcers. So it acts as an antihistamine.

Aspirine is a an:

  1. Antiseptic

  2. Antipyretic

  3. Antimalarial

  4. Narcotic


Correct Option: B
Explanation:

Aspirine is an analgesic (meaning it helps pain), and an antipyretic (meaning it reduces fever.)


Option B is correct

Assertion : Cimetidine is an antacid.
Reason : Antacid increases secretion of HCI from gastric cells.

  1. If both assertion and reason are true and reason is the correct explanation of assertion.

  2. If both assertion and reason are true but reason is not the correct explanation of assertion.

  3. If assertion is true but reason is false.

  4. If both assertion and reason are false.


Correct Option: C
Explanation:

Climetidine is an antacid which suppress secretion of HCl.

Milk of magnesia is used as:

  1. antichlor

  2. antacid

  3. antiseptic

  4. food preservative


Correct Option: B
Explanation:

Milk of magnesia consists of Magnesium hydroxide.

Antacid is a substance which neutralizes stomach acidity and used to relieve heatburn, indigestion. So, we use bases like Magnesium hydroxide or Sodium Carbonate.

Antacids are ______.

  1. drugs or other compounds that inhibits the physiological effects of histamine, used especially in the treatment of allergies.

  2. (of a drug) used to relieve pain.

  3. medicinal drugs taken to reduce tension or anxiety.

  4. (chiefly of a medicine) used to prevent or correct acidity, especially in the stomach.


Correct Option: D
Explanation:

Antacid are drugs or medicines used to prevent or correct acidity, especially in the stomach.
Examples are Cimetidine, Ranitidine, etc.

_______ is a substance which neutralizes stomach acidity, which in turn relieves heartburn, indigestion or stomach upset.

  1. Antibiotic

  2. Antacid

  3. Disinfectant

  4. Anti-fertility drug


Correct Option: B
Explanation:

An antacid (derived from the word "anti-acid") is a substance which neutralizes stomach acidity, which in turn relieves heartburn, indigestion or stomach upset.
Histamine and cimetidine are examples of antacids.

Which of these was the largest selling antacid?

  1. Cimetidine

  2. Zantac

  3. Sulpha

  4. none of these


Correct Option: A
Explanation:

Cimetidine (also called Tegamet) was the largest selling antacid.
It prevent the interaction between histamine and the receptors in the stomach wall, releasing less amount of acid.

Which of the following is an antacid?

  1. Sodium bicarbonate

  2. Magnesium hydroxide

  3. Magnesium carbonate

  4. All of the above


Correct Option: D
Explanation:

Examples of antacid include sodium bicarbonate, magnesium hydroxide, magnesium carbonate and aluminium hydroxide, as they are all basic in nature.

Most commonly used antacids are:

  1. weak bases

  2. strong bases

  3. weak acids

  4. strong acids


Correct Option: A
Explanation:


Most commonly used antacids are weak bases.
Examples of antacid includes sodium bicarbonate, magnesium hydroxide, magnesium carbonate and aluminium hydroxide. An antacid is the substance which neutralizes the acid and raise the pH to an appropriate level in stomach. They should not be caustic like strong bases.

What is an antacid?

  1. The substance which neutralizes the acid and raises the pH to an appropriate level in stomach.

  2. The substance which neutralizes the acid and lowers the pH to an appropriate level in stomach.

  3. The substance which neutralizes the base and raises the pH to an appropriate level in stomach.

  4. none of these


Correct Option: A
Explanation:

An antacid is the substance which neutralizes the acid and raises the pH to an appropriate level in stomach. In other words, antacid is a base which neutralizes excess of acid in the stomach. Examples of antacid include sodium bicarbonate, magnesium hydroxide and aluminium hydroxide. They control the symptoms and not the cause.

Which of the following cannot be used as an antacid?

  1. Rantidine

  2. Cimetidine

  3. Metal hydroxides

  4. None of the above


Correct Option: D
Explanation:

Antacid is a drug (or medicine) preventing or correcting acidity, especially in the stomach.
To neutralize the acid in stomach, antacid should be basic in nature.
All three can be used as antacids since they are basic in nature.

The main function of an antacid is:

  1. to neutralize body acid.

  2. to neutralize body base.

  3. both a and b

  4. none of these


Correct Option: A
Explanation:

Antacid is a chemical substance which removes excess acid and raises the pH to an appropriate level in stomach, preventing heatburn and upset stomach,

Name the new antacid which prevents formation of acid in stomach.

  1. Omeprazole

  2. Pantaprazole

  3. Hemoprazole

  4. none of these


Correct Option: A
Explanation:

Omeprazole is the recently developed antacid which is used to prevent the formation of acid in the stomach.

Which of the following substance is an antacid?

  1. $NaCl$

  2. $Mg(OH) _2$

  3. $HCl$

  4. $H _2SO _4$


Correct Option: B
Explanation:
Due to its mildly basic and non-toxic nature, magnesium hydroxide is widely used as an antacid to neutralize stomach acids and prevent indigestion and heartburn. 

It is also used as a laxative, antiperspirant, underarm deodorant, to treat sores, in wastewater treatment, and as a fire retardant.

Therefore, the correct option is B.

Which of the following is not used as an antacid ? 

  1. Magnesium hydroxide

  2. Sodium carbonate

  3. Sodium bicarbonate

  4. Aluminium phosphate


Correct Option: D
Explanation:

An antacid is a substance which neutralizes stomach acidity and is used to relieve heartburn, indigestion or an upset stomach.

Example- $Mg(OH) _2, Na _2CO _3, NaHCO _3$.
Aluminum phosphate is not used as an antacid.
Hence, the correct option is D.

Which of the following anti histamine does not act as antacid?

  1. Terfendine

  2. Lansoprazole

  3. Cintindine

  4. Rantidine


Correct Option: B
Explanation:

$(B)$ Lansoprazole

It does not act as antacid because it is used for treatment of nonerosive gastroesophsgeal reflux disease.

The drug cimetidine was designed to:

  1. prevent the interaction of histamine with receptors

  2. stimulates the secretion of pepsin

  3. reduce gaestro intestinal juices

  4. all of the above


Correct Option: A,C
Explanation:

The drug cimetidine (Tegamet), was designed to prevent the interaction of histamine with the receptors present in the stomach wall. This resulted in release of lesser amount of acid. The importance of the drug was so much that it remained the largest selling drug in the world until another drug, ranitidine (Zantac), was discovered.

An antacid tablet weighing 1 g containing aluminium hydroxide as the only basic substance and the rest of its components being neutral, was dissolved in 200 mL of 0.1 M HCI. The excess HCI was back titrated and required  90 mL of 0.1 N base for exact neutralization. Mill equivalents of aluminum hydroxide in the sample of antacid tablet is 

  1. 9

  2. 11

  3. 12

  4. 20


Correct Option: B

The main function of an antiacid is

  1. to neutralise body acid

  2. to neutralise body base

  3. both $a$ and $b$

  4. $None\ of\ these$


Correct Option: A

Histamine is responsible for the nasal congestion associated with common cold and allergic response to pollen.

  1. True

  2. False


Correct Option: A
Explanation:

The pollen triggers these cells in nasal chambers, causing them to release histamine and the other chemicals. Histamine dilates the small blood vessels of the nose and fluids leak out into surrounding tissues causing allergy symptoms.

So, the above statement is true.

Examples of antacids are:

  1. sodium hydroxide

  2. sodium bicarbonate

  3. magnesium hydroxide

  4. urea


Correct Option: B,C
Explanation:

Antacids: Tension and mental stress escalate the level of acid in bile juice. This hyperacidity can be combated using bases like calcium carbonate, magnesium hydroxide or aluminium hydroxide in the form of tablets or aqueous suspensions. These react with hydrochloric acid in the stomach and neutralize it partially. Gelusil and Digene are two examples of antacids. Antacids must be basic but not enough to make it caustic. Hence, options B and C are appropriate.

Urea is responsible for the nasal congestion associated with common cold and allergic response to pollen.

  1. True

  2. False


Correct Option: B
Explanation:

The pollen triggers these cells in nasal chambers, causing them to release histamine and the other chemicals. Histamine dilates the small blood vessels of the nose and fluids leak out into surrounding tissues causing allergy symptoms.

So, the above statement is false.

Which of the following is a use of $Mg(OH) _2$?

  1. It is used in fire extinguisher as a foaming agent.

  2. It is used in the preparation of fertilizers.

  3. It is used in removing stains of grease from clothes.

  4. It is used as an antacid.


Correct Option: D
Explanation:

$Mg(OH) _2$ is used as an antacid to neutralize the acidity in the stomach.

________ work by counteracting (neutralising) the acid in your stomach. 

  1. Disinfectants

  2. Antibiotics

  3. Antacids

  4. Anti-depressants


Correct Option: C
Explanation:

Antacids neutralize the acid made by your stomach, curing various problems like heartburn, upset stomach, etc. Generally, they do not have any side effects.

Which of the following is an antacid?

  1. Rantidine

  2. Histamine

  3. Cimetidine

  4. All of the above


Correct Option: D
Explanation:

An antacid is a substance which neutralizes stomach acidity, which in turn relieves heartburn, indigestion or stomach upset.
All of these are the examples of antacids.

Which of the following is an antihistamine?

  1. Brompheniramine

  2. Equanil

  3. Ranitidine

  4. Cimetidine


Correct Option: A
Explanation:

Antihistamine is a drug that inhibits the physiological effects of histamine, used especially in the treatment of allergies.


Brompheniramine is an antihistamine.

Equanil is a tranquilizer.

Ranitidine and Cimetidine are antacids.

Hence the correct option is A.

Ranitidine is also called as:

  1. Zinetac

  2. Cimetidine

  3. Pepsin

  4. Histamine


Correct Option: A
Explanation:

Ranitidine is also called as zinetac. It is an antihistamine.
It prevent the interaction between histamine and the receptors in the stomach wall, releasing less amount of acid.

Which of the following is an antihistamine?

  1. Brompheniramine

  2. Rantidine

  3. Cimetidine

  4. None of the above


Correct Option: A
Explanation:

Antihistamine is a drug or other compound that inhibits the physiological effects of histamine, used especially in the treatment of allergies.
Brompheniramine is an antihistamine drug.
Rantidine and Cimetidine are antacids.

Equanil is a/an:

  1. tranqulizer

  2. antifertility drug

  3. artificial sweetner

  4. antihistaamine


Correct Option: A
Explanation:

Equanil is a tranquilizer.
This medication is used short-term to treat symptoms of anxiety and nervousness. It acts on certain centers of the brain to help calm your nervous system which is same as tranquilizer which also have  a calming effect and eliminate both the physical and psychological effects on anxiety or fear.

The compound that causes general depressant action on the central nervous system belongs to the class of:

  1. tranquilizers

  2. analgesics

  3. antihistamines

  4. narcotic analgesics


Correct Option: A
Explanation:

Tranquilizer, a drug that is used to reduce anxiety, fear, tension, agitation, and related state of mental disturbance. 

Tranquilizers act on central nervous system and thus causes depression of central nervous system.

Substances which are used to bring down the temperature in high fever condition, are called:

  1. antiseptics

  2. pyretics

  3. antibiotics

  4. antipyretics


Correct Option: D
Explanation:

An Antipyretics is a type of medication that prevents or reduces fever by lowering body temperature from a raised state. 

Antiseptics and disinfectants either kill or prevent growth of microorganisms. Which of the following statements is not true?

  1. Chlorine and Iodine are used as strong disinfectants

  2. Dilute solutions of Boric acid and Hydrogen Peroxide are strong antiseptics

  3. Disinfectants harm the living tissues

  4. A 0.2% solution of phenol is an antiseptic while 1% solution acts as a disinfectant


Correct Option: B
Explanation:

Antiseptic and disinfectants both either kill or prevent the growth of microorganisms. The main point of difference between these two is that the former (antiseptic) are used for living beings whereas disinfectants are not safe for living tissues.

A substance like phenol in its lower concentration (0.2%) behaves as antiseptic whereas in higher concentration (1%) as a disinfectant. 
Chlorine and iodine are strong disinfectants whereas dilute solutions of boric acid and hydrogen peroxide are mild antiseptic.

Which one of the following drugs prevents the interaction of histamine with its receptor?

  1. Antihistamines

  2. Analgesics

  3. Antibiotics

  4. Disinfectants


Correct Option: A
Explanation:

Antihistamines are drugs which treat allergic rhinitis and other allergies. Antihistamines can give relief when a person has nasal congestion, sneezing, or hives because of pollen, dust mites, or animal allergy. Typically people take antihistamines as an inexpensive, generic, over-the-counter drug with few side effects. As an alternative to taking an antihistamine, people who suffer from allergies can instead avoid the substance which irritates them. However, this is not always possible as some substances, such pollen, are carried in the air, thus making allergic reaction caused by them generally unavoidable.

Penicillin is effective against gram-positive as well as gram-negative bacteria. 

  1. True

  2. False


Correct Option: B
Explanation:

Penicillin is effective only against Gram-positive bacteria because Gram-negative bacteria have a lipopolysaccharide and protein layer that surrounds the peptidoglycan layer of the cell wall, preventing penicillin from attacking.

Which of the following is not an antihistamine?

  1. Brompheniramine

  2. Terfenadine

  3. Iproniazid

  4. Ranitidine


Correct Option: C
Explanation:

Iproniazid (Marslid, Rivivol, Euphozid, Iprazid, Ipronid, Ipronin) is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class. It is a xenobiotic that was originally designed to treat tuberculosis, but was later most prominently used as an antidepressany drug.

Azoic dyeing is a technique in which an insoluble ..................... compound dye is produced directly onto the fiber.

  1. azo

  2. sulphur containing

  3. carbonyl

  4. carboxylic acid


Correct Option: A
Explanation:

Azoic dyeing is a technique in which an insoluble Azo dye is produced directly onto or within the fiber. This is achieved by treating a fiber with both diazo and coupling components.
With suitable adjustment of dyebath conditions, the two components react
to produce the required insoluble azo dye. This technique of dyeing is unique, in that the final color is controlled by the choice of the diazoic and coupling components.
Hence option A is correct.

Reactive dyes utilize a _________ attached to a substituent that is capable of directly reacting with the fibre substrate.

  1. chromophore

  2. auxochrome

  3. chlorophyll

  4. none of the above


Correct Option: A
Explanation:

Reactive dyes utilize a chromophore attached to a substituent that is capable of directly reacting with the fiber substrate. The covalent bonds that attach the reactive dye to natural fibers make them among the most permanent of dyes. 'Cold' reactive dyes, such as Procion MX, Cibacron F, and Drimarene K, are very easy to use because the dye can be applied at room temperature. Reactive dyes are by far the best choice for dyeing cotton and other cellulose fibers at home or in the art studio.

Hence option $A$ is correct.

Dispersed dye was originally developed for the dyeing of cellulose acetate,
and are water-insoluble this dye is mainly used to dye:

  1. nylon

  2. polyster

  3. both A and B

  4. wool


Correct Option: B,C
Explanation:

Dispersed dyes were originally developed for the dyeing of cellulose acetate and are water-insoluble. The dyes are finely ground in the presence of a
dispersing agent and sold as a paste, or spray-dried and sold as a
powder. Their main use is to dye polyester but they can also be used to dye nylon.
Hence option C is correct.

Assertion : Penicillin (G) is an antihistamine.


Reason: Penicillin (G) is effective against gram-positive bacteria.

Read the above assertion and reason and choose the correct option regarding it.

  1. Both Assertion and Reason are correct and Reason is the correct explanation for Assertion

  2. Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion

  3. Both Assertion and Reason are incorrect

  4. Assertion is correct but Reason is incorrect

  5. Assertion is incorrect but Reason is correct


Correct Option: E
Explanation:

The assertion that Penicillin (G) is an antihistamine is incorrect. Penicillin (G) is an antibiotic. It is a narrow spectrum antibiotic. Hence it effective against both gram positive as well as Gram negative bacteria. Therefore, the Reason is correct.
Hence, option E is the right answer.

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