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Use of microorganisms in medicine - class-VIII

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Streptomycin is obtained from 

  1. Streptomyces griseus

  2. S. cerevisiae

  3. S. venezuelae

  4. S. rimosus


Correct Option: A
Explanation:

S. cerevisiae is used in the formation of dough while S.venezuelae is used in obtaining chloramphenicol drug. Oxytetracycline is obtained from S.rimosus. 

Antibiotics are obtained from 

  1. bacteria

  2. fungi

  3. actinomycetes

  4. all of these.


Correct Option: D
Explanation:
Antibiotic are obtained from bacteria (like streptomycin), fungi (like Penicillium) and actinomycetes (like Novobiocin).
So, the correct option is 'all of these'

Normal E. coli cells carry resistance against which of the following antibiotics?

  1. Chloramphenicol

  2. Ampicillin

  3. Tetracycline

  4. None of these


Correct Option: D
Explanation:
A. Chloramphenicol is an antibiotic used to treat bacterial infections such as eye infections.
B. Ampicillin is an antibiotic used to treat bacterial infections such as ear infections.
C. Tetracycline is an antibiotic used to treat bacterial infections such as cholera, acne etc.
All these antibiotics are used to kill or inhibit the growth of bacteria. Normal E. coli cells do not carry resistance against any of the following antibiotics. However, the plasmids of E. coli are genetically modified and genes carrying resistance for these antibiotics is integrated within the plasmid and this genetically engineered plasmid is transformed into host cells.
So, the correct answer is 'None of the above'.

Which of these antibiotics is/are obtained from bacteria?

  1. Penicillin

  2. Erythromycin

  3. Polio vaccine

  4. All of the above


Correct Option: B
Explanation:

Penicillin is a secondary metabolite of certain species of Penicillium and is produced when the growth of the fungus is inhibited by stress.

Erythromycin is a bacteriostatic antibiotic macrolide produced by Streptomyces erythreus.
Polio vaccine contains killed virus and is given by injection. It is given to prevent polio, an infectious disease of the nervous system.

So, the correct option is 'Erythromycin'.

How the antibiotics work?

  1. They block the biochemical pathway of some cells of host

  2. They block the biochemical pathway of pathogens

  3. They only bring down the effect of disease

  4. They comfort the patient


Correct Option: B
Explanation:

Antibiotics are compounds which are used to treat bacterial infection. They work by blocking the biochemical pathway of pathogens. They inhibit the synthesis of enzymes required for cell wall biosynthesis, nucleic acid metabolism or protein synthesis. They also act by disrupting the cell membrane of pathogens.

Thus, the correct answer is 'They block the biochemical pathway of pathogens.'

Why do antibiotics kill bacteria but not viruses ? 

  1. Antibiotics stimulate the immune system against bacteria but not viruses

  2. Viruses have a ways of blocking antibiotics

  3. Viruses are too small to be affected by antibiotics

  4. Viruses do not have a metabolism


Correct Option: D
Explanation:

  • Bacteria (except in spore stage) must be continuously metabolically active most of the time and thus can be cured at any time. Viruses are metabolically inert until they got a host cell and thus they are not susceptible to the actions of antivirals until then. An exception would be drugs that block viral adhesion to host cells, thus preventing their entry.
  • The virus often hijacks host genes, thus their protein can be closely related to host proteins. So it is difficult to distinguish between host and virus proteins.
  • The virus does not have a cell wall as bacteria. Antibiotics stop the making of a cell wall in bacteria. Thus they remain unaffected by antibiotics.

So the correct answer is 'Viruses do not have a metabolism'.

For minor troubles such as cold, antibiotics should not be consumed because

  1. They can damage intestinal wall.

  2. They can create antibiotic resistant bacteria in the future.

  3. Both A and B.

  4. None of the above.


Correct Option: B
Explanation:

Antibiotics should not be used for minor troubles like cold because some pathogenic bacteria could develop resistance to the action of this antibiotic. And on the excessive use of antibiotic, they can cause damage to the beneficiary intestinal micro-organisms. So, the correct answer is option B.

Which among the following is an antibiotic?

  1. Sodium bicarbonate

  2. Streptomycin

  3. Alcohol

  4. Yeast


Correct Option: B
Explanation:

Antibiotics are the chemicals that kill or inhibit the growth of bacteria and are used to treat bacterial infections. They either prevent the bacterial cells from multiplying.

Streptomycin is an antibiotic drug which hinders the reproductive pathway of the plant.
So, the correct answer is option B.

Which is the first antibiotic which was extracted from bacteria?

  1. Tubulin

  2. Penicillin

  3. Streptomycin

  4. Charmoycin


Correct Option: C
Explanation:

Penicillin is the first antibiotic extracted from fungi, whereas streptomycin is the first antibiotic extracted from bacteria Streptomyces griseus. 

How are microorganisms useful to us?

  1. The production of chemical fertilizers

  2. The production of fireworks

  3. The production of soft drinks

  4. The production of antibiotics


Correct Option: D
Explanation:

The antibiotics are the chemical compounds which is produced by one organism which inhibit the growth of the other organism. The antibiotics can be used for the control of the growth of the bacteria or organisms causing infections. The microorganisms like the bacterial and fungal species are used for the production of the antibiotics which can be used for the control of other microorganisms.

Thus, the correct answer is option D. 

Plants have been a source of important compounds for human medicine. All of these compounds have been made from plant parts except

  1. Morphine

  2. Aspirin

  3. Vinblastine, to treat cancer

  4. Coumadin, an anticoagulant

  5. Penicillin, an antibiotic


Correct Option: E
Explanation:

Penicillin antibiotic is derived from the fungi Penicillium whereas the other compounds are derived from plant parts like morphine from opium latex, aspirin from salicylate-rich plants, vinblastine from Vinca rosea and coumadin is another name for warfarin.

Which among the following is not an antibiotic?

  1. Citric acid

  2. Streptomycin

  3. Cephalosporin

  4. Griseofulvin


Correct Option: A
Explanation:

  • Streptomycin is an antibiotic used in the treatment of bacterial infections like tuberculosis, endocarditis, brucellosis, plague, rat bite fever, etc. It is a broad spectrum antibiotic.
  • Cephalosporin is a beta-lactam antibiotic. It is used in the treatment of bacterial infections like respiratory tract infections, skin infections, urinary tract infections.
  • Griseofulvin is an antifungal antibiotic. It is used in the treatment of skin infections like ringworm, athlete's foot, infections of the scalp, fingernails, etc.
Thus, the correct answer is 'Citric acid.'

The chemicals released by bacteria, which kills other bacteria are

  1. Antibiotics

  2. Antibodies

  3. Antigens

  4. Allergens


Correct Option: A
Explanation:

Antibiotic is a chemical which is released by a bacteria and inhibits the growth of other bacteria. It acts by either killing bacteria or preventing their reproduction. 

Thus, the correct answer is 'Antibiotics.'

An antibiotic, which is active against fungi is

  1. Neomycin

  2. Terramycin

  3. Polyenes

  4. Streptomycin


Correct Option: C
Explanation:

Antibiotics are antimicrobial substances produced by microorganisms. They are used in the treatment of bacterial infections. Examples of antibiotics include Neomycin, terramycin, Streptmomycin. Polyenes are antifungal antibiotics produced by bacterium Streptomyces species which are used to treat fungal infections. They act by changing the fungal cell membrane by complexing with sterols.

Thus, the correct answer is 'Polyenes.'

Identify a fungus with medicinal importance.

  1. Penicillium

  2. Cercospora

  3. Agaricus

  4. Saccharomyces


Correct Option: A
Explanation:

Penicillin is a secondary metabolite of certain species of Penicillium and is produced when the growth of the fungus is inhibited by stress. It is not produced during active growth. Production is also limited by feedback in the synthesis pathway of penicillin.

So, the correct option is 'Penicillium'.

Broad spectrum antibiotics are the ones which attack

  1. Pathogens as well as hosts

  2. A wide range of pathogens

  3. Only a pathogen

  4. Only host


Correct Option: B

Mode of action of Novobiocin is

  1. Induces abnormal protein synthesis

  2. Inhibits DNA polymerisation

  3. Interferes with protein synthesis

  4. Inhibits cell wall synthesis


Correct Option: B

The molecular structure of penicillin antibiotic is

  1. Macrocyclic lactone

  2. Glycoside linkage in amino sugar

  3. $\beta$-lactam ring

  4. Polyaena and nonpolyaene


Correct Option: C
Explanation:

Penicillin is obtained from Penicillium chrysogenum. Penicillin is a secondary metabolite of certain species of Penicillium and is produced when the growth of the fungus is inhibited by stress. Its structure contains β- lactam ring with a molecular structure of 339.4 g/mol. It was discovered by Alexander Fleming.

So, the correct answer is 'β- lactam ring'

Which of the following antibiotics kills bacterial cells by inhibiting the polymerisation of peptidoglycans?

  1. Aminoglycoside

  2. Fluoroquinolones

  3. Quinine

  4. Penicillin


Correct Option: D
Explanation:

Penicillin is a secondary metabolite of certain species of Penicillium and is produced when the growth of the fungus is inhibited by stress. It is not produced during active growth. Production is also limited by feedback in the synthesis pathway of penicillin. It was discovered by Alexander Fleming.

So, the correct option is 'Penicillin.

Some antibiotics act ionospheres, which means that they ______________________.

  1. Interfere directly with bacterial cell wall synthesis

  2. Increase cell membrane permeability to specific ions

  3. Inhibit both transcription and translation

  4. Inhibit electrophoresis separation of ions


Correct Option: A

Microorganisms are our friends and foes. Some of them are useful for us while some of them are harmful. From the given list sort out useful and harmful actions of microorganisms.
Production of antibiotics, food spoiling, curd preparation, vaccine production, citrus canker.

  1. Useful: Curd preparation, citrus canker, production of antibiotics

    Harmful: Food spoiling, vaccine production

  2. Useful: Production of antibiotics, curd preparation, vaccine production

    Harmful: Food spoiling, citrus canker

  3. Useful: Citrus canker, vaccine production, curd preparation

    Harmful: Food spoiling, production of antibiotics

  4. Useful: Vaccine production, curd preparation

    Harmful: Food spoiling, citrus canker, production of antibiotics


Correct Option: B
Explanation:
An antibiotic is a chemical substance that inhibits the growth of bacteria. They hinder the reproductive cycle of the bacteria inside the body of the host.
Lactobacillus is a genus of bacteria, which can convert sugars into lactic acid by means of fermentation. 
A vaccine is a biological preparation that provides active acquired immunity to a particular disease. It has killed or weakened suspension of microorganism which generates the immune response.
Citrus canker is a disease affecting citrus species caused by the bacterium Xanthomonas axopods. The infection causes lesions on the leaves, stems, and fruit of citrus trees, including lime, oranges, and grapefruit. 

Micorganism like fungus releases toxins which spoils the food.
So, the correct answer is option B.

An antibody is best described as

  1. A particle

  2. An organism

  3. A molecule

  4. A fragment


Correct Option: C
Explanation:

An antibody is commonly known as an immunoglobulin (Ig). It is a large, Y-shape protein molecule produced by plasma cells in response to the antigen.

So, the correct answer is option C.

The drug used in relaxing mental and physical stress is

  1. Morphine

  2. Quinine

  3. Ginseng

  4. Digoxin


Correct Option: C
Explanation:
  • The botanical name of ginseng is Panax ginseng. It is from family Araliaceae.  is obtained from the roots of the plant and used to cure a variety of diseases.
  • It is used for improving thinking, memory, physical stamina and athletic endurance. 
  • Some people use it to help them cope with mental and physical stress and as a general tonic for improving well-being. 
  • It is also used for depression, anxiety, for boosting the immune system and for fighting particular infections in a lung disease called as cystic fibrosis. 
  • So, the correct answer is option C.

Which one of the following is a antifungal antibiotic?

  1. Streptomycin

  2. Aureomycin

  3. Griseofulvin

  4. Chloromycetin


Correct Option: C
Explanation:
1. Streptomycin is an antibacterial antibiotic.
2. Aureomycin is a brand name of medication included in antiinfectives and antiseptics.
3. Griseofulvin is an effective antifungal medication used to treat infections of skin, scalp, nails etc.so it is used to treat only fungal infections.
4. Chloromycetin is an effective medicine used for the treatment of serious infections caused by bacteria only.
So, the correct answer is 'Griseofulvin'.

Penicillin was used during 

  1. World war II

  2. World war I

  3. Both A and B

  4. III war of Panipat


Correct Option: A
Explanation:

Penicillin is a secondary metabolite of certain species of Penicillium and is produced when the growth of the fungus is inhibited by stress. It was used during World War II. It is not produced during active growth. Production is also limited by feedback in the synthesis pathway of penicillin.

So, the correct option is 'World war II'.

Streptomycin is effective for treatment of pathogens which are 

  1. Gram $(+)$ bacteria 

  2. Gram $(-)$ bacteria

  3. Both A and B

  4. Gram neutral


Correct Option: C
Explanation:

Streptomycin is an antibiotic, a medicine used to inhibit the growth of microbes. Streptomycin is a broad spectrum antibiotic which works against both gram negative and gram-positive bacteria.

So, the correct answer is 'Both A and B'

The antibiotic inhibiting cell wall formation in bacterial cells is

  1. Clavicin

  2. Penicillin

  3. Ergotine

  4. None of the above


Correct Option: B

The latest broad-spectrum antibiotics are

  1. Cyclosporins

  2. 4-Quinolones

  3. Gentamicins

  4. Neomycins


Correct Option: B
Explanation:

Antibiotics are the medicine that inhibits the growth of disease-causing microbes inside the body. There are two kinds of Antibiotics broad and narrow spectrum antibiotics. Broad spectrum antibiotics can be used for both gram-positive and gram-negative bacteria. Latest of them are 4-Quinolones.

So, the correct option is '4-Quinolones'.

Four people W, X, Y and Z were suffering with common cold. X and Y took antibiotics while W and Z did not. An experiment was done and W and Y were subjected to some bacterial infection during cold. Which of the following can be the observation of the experiment?

  1. Both X and Z took almost the same time in getting normal because common cold is a viral disease

  2. Y recovered earlier than W because antibiotics taken by Y resisted bacterial infection although antibiotics did not affect cold

  3. Z recovered earlier than W because it was not subjected to bacterial infection

  4. All of the above


Correct Option: D
Explanation:

Usually, antibiotics do not work against colds, flu, bronchitis, or sinus infections because these are viruses. Antibiotics are needed to treat infections and illnesses that are caused by bacteria. Taking an antibiotic unnecessarily has led to the growth of several strains of common bacteria that are now antibiotic resistant. For these and other reasons, it is important to only use antibiotics in situations where they are needed.

So, the correct answer is option D.

A particular species of which one of the following is the source bacterium of the antibiotic discovered next to penicillin for the treatment of tuberculosis?

  1. Escherichia

  2. Streptomyces

  3. Rhizobium

  4. Nitrobacter


Correct Option: B
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