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Glucose metabolism - class-XI

Description: glucose metabolism
Number of Questions: 26
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Tags: carbohydrate metabolism biology energy and respiration bio-chemistry zoology life processes the respiratory system respiration in organisms respiration
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Which is true about the end products of glycolysis?
  1. $2\,pyruvic \,acid+2ATP+{2NADH} _{2}$

  2. $2\,pyruvic \,acid+{2NADH} _{2}$

  3. $1\,pyruvic \,acid+2ATP+{2NADH} _{2}$

  4. $2\,pyruvic \,acid+1ATP+{1NADH} _{2}$


Correct Option: A
Explanation:
In glycolysis, two molecules of ATP are consumed during two phosphorylation reactions to form fructose 1, 6-biphosphate. In return, four molecules of ATP are produced by substrate-level phosphorylation (conversion of 1, 3-biphosphoglycerate to 3-phosphoglycerate and phosphoenolpyruvate to pyruvate). Two molecules of ${NADH} _{2}$ are formed at the time of oxidation of glyceraldehyde 3-phosphate to 1, 3-biphosphoglycerate. The net reaction of glycolysis is as follows:

$Glucose+{2NAD}^{+}+2ADP+{2H} _{3}{PO} _{4}\rightarrow2Pyruvate+2NADH+{2H}^{+}+2ATP$

Each NADH is equivalent to 3 ATP, so the net gain in glycolysis is 8 ATP.

So the correct answer is '$2\,pyruvic \,acid+2ATP+{2NADH} _{2}$'.

In glycolysis, glucose molecule is converted into which substance?

  1. Lactic acid

  2. Ethanol

  3. Pyruvate

  4. Amino acid


Correct Option: C
Explanation:

The process by which the glucose (6C compound) is split into two molecules of pyruvic acid (3C compound) is called glycolysis or EMP pathway. It occurs in the cytoplasm. In glycolysis, 4ATP and 2NADH$ _2$ molecules are formed and 2ATP molecules are consumed in hexose phase

So, the correct answer is 'Pyruvate'

For the start of respiration, a living cell requires

  1. Glucose

  2. Glucose + $O _2$

  3. $O _2$

  4. Glucose + ATP


Correct Option: D
Explanation:

The mechanism of respiration is initiated by breaking down glucose to pyruvic acid without the help of oxygen. The initial process occurs in the cytosol of cells which requires glucose as well as ATP molecules which provide energy for the process to start. This initial process is known as glycolysis and it takes place in 10 steps in which total 4 ATP molecules are produced and 2 ATP molecules are consumed. Thus, these are the net production of 2 ATP molecules. 

Thus, the correct answer is option D. 

How many ATP are produced in mitochondria on complete oxidation of glucose?

  1. $24$

  2. $30$

  3. $34$

  4. $38$


Correct Option: A
Explanation:
Name of process   Site  Total ATP formation
 Glycolysis  Cytoplasm  2NADH(i.e. 6ATP)+ 2ATP = 8ATP 
 Conversion of pyruvate to acetyl CoA  Cytoplasm  2NADH = 6ATP
 Kreb's cycle  Mitochondria  6NADH + 2 FADH + 2GTP= 18ATP +4ATP + 2ATP  = 24 ATP

 1 NADH = 3 ATP, 1 FADH = 2 ATP

So, the correct answer is '$24$'

When one molecule of sucrose is subjected to phosphorylation how many ATPs are consumed?

  1. 2

  2. 6

  3. 3

  4. 4


Correct Option: A
Explanation:

During the conversion of fructose-1,6-bis-phosphate to lactate, the pathway generates a total of four molecules of ATP, resulting in a net yield of two ATP per glucose consumed.

correct answer is A.

In which of the following steps dehydrogenate occurs? 

  1. glucose $\rightarrow$ glucose 6-phosphate

  2. 3 - PGA $\rightarrow$ 2 - PGA

  3. PEPA $\rightarrow$pyruvate

  4. PGAL $\rightarrow$ 1, 3diPGA


Correct Option: A
Explanation:
The G6PDwhich is glucose dehydrogenate gene provides instructions for making an enzyme called glucose-6-phosphate dehydrogenase. This enzyme, which is active in virtually all types of cells, is involved in the normal processing of carbohydrates. This enzyme helps protect red blood cells from damage and premature destruction.
So, the correct answer is glucose $\rightarrow$ glucose 6-phosphate

Match the scientist and their discoveries given in Column I and II correctly and choose the correct combination from the following.

   List I    List II
 A  P Mitchell  p  Pentose phosphate pathway
 B  Warberg and Dickens  q  Chemiosmotic mechanism
 C  EMP pathway  r  Embden-Meyerhof and Parnas
 D  Anaerobic respiration  s  Pasteur
     t  Kostychev
  1. A- p, B- q, C- r, D- t

  2. A- q, B- p, C- s, D- t

  3. A- q B- p, C- r, D- t

  4. A- q, B- p, C- t, D- s


Correct Option: C
Explanation:

Peter Dennis Mitchell was a British biochemist, who was awarded the 1978 Nobel prize for chemistry for his discovery of the 'chemiosmotic mechanism' of ATP synthesis.
Pentose phosphate pathway was discovered by Warburg and Dickens. It is a
 pathway of hexose oxidation in which glucose-6-phosphate undergoes two successive oxidations by NADP, the final one being oxidative decarboxylation to form a pentose phosphate.
EMP pathway is known as 'Embden-Meyerhof-Parnas pathway'. It is also called as glycolysis. It converts glucose to pyruvate.
Kostychev was first Russian scientist to explain anaerobic respiration. He applied his knowledge of microbiology to the study of the decomposition of organic matter in the soil. Thus, the correct answer is option C.

In pentose phosphate pathway, which of the following process is lacking?

  1. Kreb's cycle

  2. Glycolysis

  3. Oxidative phosphorylation

  4. All of the above


Correct Option: D
Explanation:

The pentose phosphate pathway also called the hexose monophosphate shunt, is a shunt from glycolysis designed to produce either NADPH or ribose or both. There are two distinct phases in the pathway. The first is the oxidative phase, in which NADPH is generated, and the second is the non-oxidative synthesis of 5-carbon sugars. In the pentose phosphate pathway, glucose 6-phosphate is directly oxidized without entering glycolysis. Even Kreb's cycle and oxidative phosphorylation doesn't happen in pentose phosphate pathway.

So, the correct answer is 'All of the above'.


The pentose phosphate pathway (PPP) of most organisms take place in

  1. Mitochondria

  2. Cytoplasm

  3. Chloroplast, peroxisome and mitochondrion

  4. Chloroplast, glyoxysome and mitochondrion

  5. Chloroplast, lysosome and mitochondrion


Correct Option: B
Explanation:

Pentose phosphate pathway is also called as phosphogluconate pathway or Hexose Monophosphate Shunt (HMP Shunt). It occurs in most organisms in cytoplasm. It results in generation of NADPH, ribose-5-phosphate (R5P) and erythrose 4-phosphate (E4P). R5P is precursor for the synthesis of nucleotides. E4P is involved in the synthesis of aromatic amino acids. 

Thus, the correct answer is option B.

During the complete oxidation of one glucose, how many reduced coenzymes are produced due to following processes?
(A) Link reaction
(B) Glycolysis
(C) Krebs cycle
Choose the correct option from the following.

  1. $A = 1, B = 1, C = 4$

  2. $A = 2, B = 2, C = 4$

  3. $A = 2, B = 2, C = 3$

  4. $A = 2, B = 2, C = 8$


Correct Option: A,D
Explanation:

In the oxidation of one glucose molecule, during aerobic respiration, 2NADH2 in link reaction, 2NADH2 in glycolysis, 8NADH2 in Krebs cycle are formed.

So, the correct option is ‘A=1, B=1, C=4 or A=2, B=2, C=8’.

How many ${ CO } _{ 2 }$ molecules are produced from one pyruvate on complete oxidation :-

  1. 1

  2. 2

  3. 3

  4. 4


Correct Option: B
Explanation:

During the complete oxidation of pyruvate, two carbon atoms are lost in the form of CO2 - one during the conversion of isocitrate to alpha-ketoglutarate and the second during the conversion of alpha-ketoglutarate to succinyl CoA.
So, the correct answer is '2'.

Sequence of aerobic metabolic breakdown of glucose is

  1. Glycolysis-transition-citric acid cycle-electron transport system

  2. Transition-glycolysis-electron transport-citric acid cycle

  3. Electron transport system-citric acid cycle- transition-glycolysis

  4. None of the above


Correct Option: A
Explanation:

  • For the aerobic respiration the substrate glucose has  to undergo a following set of process 
  • First of which is glycolysis where the molecule of glucose is broken down to 2 molecules of pyruvate.
  • These pyruvate molecules are to be cconverted to Acetyl CoA so that it can enter the mitochondrial membrane and undergo kerb cycle.
  • After being converted to acetyl coA it takes part in kerb cycle where molecules of NADH, FADH and ATP are formed.
  • These NADH, FADH molecules are the electron acceptors which are used in ETS to transport electron and hydrogen ions through the complexs.
  • These electrons and hydrogen ions are used for the formation of ATP via ATP synthase.
  • Therefore the process for the aerobic breakdown of glucose is Glycolysis followed by transition of pyruvate then citric acid cycle which is followed by electron transport system.
  • Therefore the correct answer is 'Glycolysis-transition-citric acid cycle-electron transport system'








How many oxygen atoms are required for the complete oxidation of one molecule of pyruvate?

  1. 2

  2. 5

  3. 4

  4. 3


Correct Option: A
Explanation:

Under Anaerobic conditions, Pyruvic Acid enters in matrix of mitochondrion and undergoes oxidative decarboxylation to form 2 carbon energy rich compound called Acetyl Co A.

This process utilizes 2 oxygen atoms. Incomplete oxidation of Pyruvate leads to the formation of lactic acid in muscles and formation of ethyl alcohol in yeast as a process of fermentation.

So, the correct answer is '2'

The receptors for opioids are present in?

  1. Gastrointestinal tract

  2. CNS

  3. Circulatory and respiratory systems

  4. Both $(1)$ & $(2)$


Correct Option: D
Explanation:

Opioids are a type of drug. They are also referred to as narcotics. In the human body, the opioid receptors are present at a variety of locations, including the brain, in the spinal cord, on peripheral neurons, and the digestive tract. They often act as pain relievers.

So, the correct answer is 'Both (1) & (2)'.
(1(2)'.

How many molecules of NADH are produced when four molecules of phosphoglyceraldehde are converted into four molecules of pyruvate?

  1. $2$

  2. $6$

  3. $8$

  4. $4$


Correct Option: A
Explanation:

Glycolysis is a series of reactions that extract energy from glucose by splitting it into two three-carbon molecules called pyruvates. Glycolysis takes place in the cytosol of a cell, and it can be broken down into two main phases: the energy-requiring phase and  the energy-releasing phase. Each three-carbon sugar is converted into another three-carbon molecule, pyruvate, through a series of reactions. In these reactions, ATP molecules and one NADH molecule are made. Because this phase takes place twice, once for each of the two three-carbon sugars, it makes four ATP and two NADH overall.

So the correct option is '2'.

During glycolysis the number of ATP molecules utilized to change glucose into fructose 1, 6 diphosphate are

  1. 4

  2. 3

  3. 2

  4. 1


Correct Option: C
Explanation:

2 molecules of ATP is utilized during the conversion of glucose into fructose 1,6 diphosphate.

So the correct option is '2'.

Substrate -level phosphorylation accounts for approximately what percentage of the ATP formed by the reactions of glycolysis?

  1. $0\%$

  2. $2\%$

  3. $10\%$

  4. $100\%$


Correct Option: D
Explanation:

Substrate-level phosphorylation is the direct transfer of phosphate group to ADP to form ATP. It accounts of 100% of the ATP formed by the reactions of glycolysis. The first substrate-level phosphorylation occurs when 1, 3 - diphosphoglyceraldehyde is converted to 1, 3 - diphosphoglyceric acid and 2 NADH$ _2$ are formed, that is 6 ATP are formed. The 1, 3-diphosphoglyceric acid is then dephosphorylated to 3 phosphoglyceric acid producing 2 ATP via substrate-level phosphorylation. The second substrate-level phosphorylation occurs when phosphoenolpyruvic acid is converted to pyruvic acid producing 2 ATP molecules.

Thus, the correct answer is option D. 

Which hormone secreted by thyroid gland ?

  1. Thyroxine

  2. Adrenalin

  3. Testosterone

  4. Phyrotrophic


Correct Option: A
Explanation:
  • The thyroid gland is composed of two lobes that are located on either side of the trachea.
  • Follicular cells of the thyroid gland synthesize two hormones, tetraiodothyronine or thyroxine ($T _4$) and triiodothyronine ($T _3$). 
  • Thyroid hormones play an important role in the regulation of the basal metabolic rate. 
  • Hence the hormone secreted by the thyroid gland is thyroxine.
  • So, the correct answer is 'Thyroxine'.

Glycogenolysis is

  1. Oxidation of sugar

  2. Conversion of glycogen into glucose

  3. Conversion of glucose into glycogen

  4. Conversion of glycogen into fat


Correct Option: B

Glycogenolysis occurs in.

  1. Muscles

  2. Liver

  3. Kidney

  4. Small intestine


Correct Option: B

Conversion of glycogen into glucose is

  1. Gluconeogenesis

  2. Glycolysis

  3. Glycogenolysis

  4. Glycogenesis


Correct Option: C

Conversion of excess glucose into glycogen is 

  1. Glyconeogenesis

  2. Glycogenolysis

  3. Glycolysis

  4. Glycogenesis


Correct Option: D

Which process helps in maintaining blood glucose level under fasting

  1. Glycogenesis

  2. Glycogenolysis

  3. Lipogenesis

  4. Glycolysis


Correct Option: B

Glycogenolysis involves

  1. Conversion of sugar into glycogen

  2. Oxidation of sugar

  3. Conversion of glycogen into fat

  4. Conversion of glycogen into sugar


Correct Option: D

Column I contains some terms and Column II contains their
meanings. Match them properly and choose the right answer

Column I Colunn II
A Glycogenesis 1 Conversion of glycogen toglucose
B Glycosuria 2 Conversion of glucose toglycogen
C Gluconeogenesis 3 Excretion of glucose in urine
D Glycogenolysis 4 Conversion ofnoncarbohydrate sources toglucose
5 Conversion of glucose tostarch













  1. A-1, B - 2, C - 3, D - 4

  2. A - 2, B - 3, C - 4, D -1

  3. A - 2, B - L C - 3, D -4

  4. A -1, B - 5, C - 2, D -4


Correct Option: B

Which of the following amino acids is NOT involved in gluconeogenesis?

  1. Alanine

  2. Lysine

  3. Glutamate

  4. Arginine


Correct Option: B
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