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Amphibolic pathway - class-XI

Description: amphibolic pathway
Number of Questions: 23
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Tags: respiration life processes in living organisms- part 1 respiration in plants biology
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Which of the following forms the connecting link between glycolysis and Kreb's cycle?

  1. Glucose

  2. Ethyl alcohol

  3. Lactic acid

  4. Pyruvic acid


Correct Option: D
Explanation:
Pyruvic acid is produced as a final end product of glycolysis. This pyruvic acid then forms acetyl CoA. This acetyl CoA, acts as initial compound of Kreb's cycle.
So, the correct answer is 'Pyruvic acid'

The details of tricarboxylic acid pathway was worked out by

  1. Miescher

  2. Hans Krebs

  3. Pasteur

  4. None of the above


Correct Option: B
Explanation:

Sir Hans Adolf Krebs was a German born British physician and biochemist. He was the pioneer scientist in study of cellular respiration, a biochemical pathway in cells for production of energy.

Out of 38 molecules of ATP produced after aerobic respiration of glucose, the break up in ATP production in glycolysis (P). pyruvic acid to acetyl CoA formation (Q) and Krebs cycle (R) is 

  1. P = 2, Q = 6, R = 30

  2. P = 8, Q = 6, R = 24

  3. P = 8, Q = 10, R = 20

  4. P = 2, Q = 12, R = 24


Correct Option: B

Aerobic respiratory pathway is appropriate termed ___________.

  1. Anabolic

  2. Catabolic

  3. Amphibolic

  4. Parabolic


Correct Option: C

Which of the two statements together support that respiratory pathway is an amphibolic pathway.
i) Fats breakdown to glycerol and fatty acids, subsequently yields acetyl CoA
ii) In respiration C-C bonds of complex compounds breakdown through oxidation leading to release of energy
iii) Acetyl CoA from respiratory pathway is withdrawn for synthesis of fatty acids
iv) Proteins are degraded by protease to amino acids and enter the respiratory pathway

  1. i, ii

  2. i, iv

  3. ii, iv

  4. ii, iii


Correct Option: D

Largest amount of phosphate bound energy is produced in the process of respiration during 

  1. Anaerobic respiration

  2. Glycolysis

  3. Krebs cycle

  4. None of the above


Correct Option: C
Explanation:

During the process of glycolysis 8 ATP molecules are produced in aerobic respiration. In the case of Krebs cycle 30 ATP molecules can be produced.

The process by which the energy of glucose is released under aerobic respiration was discovered by

  1. Hopkins

  2. Lister

  3. Krebs

  4. Pasteur


Correct Option: C
Explanation:

The process by which the energy of glucose is released under aerobic respiration, was discovered by Hans Krebs. The Krebs cycle is a part of cellular respiration. It is a series of chemical reactions used by all aerobic organisms to generate energy.

Aerobic respiratory pathway is appropriately called as

  1. Anabolic

  2. Catbolic

  3. Amphibolic

  4. Parabolic


Correct Option: C
Explanation:

Aerobic respiratory pathway is appropriately called amphibolic pathway. It contains both catabolic and anabolic reactions. The pathway is catabolic because in this pathway, glucose is broken down into carbon dioxide and water. It is also anabolic pathway as energy rich ATP molecule is produced during this pathway. These ATP molecules are later used to carry out various reaction. 

Thus, the correct answer is option C.

Kerbs cycle __________________.

  1. Liberates a minor part of energy during respiration

  2. Is operative in photorespiration

  3. Reactions are independent of oxygen supply

  4. Is a like between carbohydrate and nitrogen metabolism


Correct Option: A

The site of Krebs cycle is

  1. Cytoplasm

  2. Mitochondrial matrix

  3. Intermembrane space of mitochondria

  4. Racker's particles


Correct Option: B

In Kreb's cycle formation of ___________________.

  1. $34$ ATP takes place

  2. $38$ ATP takes place

  3. $15$ ATP from each acetyl Co-A takes place

  4. $12$ ATP from each acetyl Co-A takes place $(24\ ATP)$


Correct Option: A

How many oxidation step take place during glycolysis, link reaction and Kreb's cycle.

  1. $1, 1 and 1$

  2. $1, 1 and 4$

  3. $1, 1 and 3$

  4. $1, 1 and 8$


Correct Option: B
Respiratory Pathway is _______.
  1. Catabolic

  2. Amphibolic

  3. Anabolic

  4. Endergonic


Correct Option: B
Explanation:

The same respiratory process which acts as a catabolic pathway for respiratory substrates also acts as an anabolic pathway for the synthesis of various intermediary metabolic products and secondary metabolites. The respiratory pathway, therefore, acts both as catabolic as well as an anabolic pathway. Thus, it is better to call it the amphibolic pathway rather than a catabolic pathway alone.

So the correct option is B.

During amphibolic pathway, acetyl Co-A can perform the biosynthesis of 

  1. Amino acid

  2. Gibberellic acid

  3. Fatty acid

  4. All of the above


Correct Option: C
Explanation:

Fatty acid synthesis takes place in the cytoplasm of the cell. It is the creation of fatty acids from acetyl-CoA and NADPH through the action of enzymes called fatty acid synthases. Most of the acetyl-CoA which is converted into fatty acids is derived from carbohydrates via the glycolytic pathway. 

So, the correct option is 'Fatty acid'.

Find the incorrect match (with respect to ATP gain) -

  1. Bacterial cell - $38$ ATP or $2$ ATp

  2. Citric Acid Cycle - $12$ ATP

  3. Nerve cell - $38$ ATP

  4. Liver cell - $38$ ATP


Correct Option: A
Explanation:

The Kreb’s Cycle gives 3 moles of NADH1 mole of FADH and 1 mole of ATP per cycle of substrate i.e per 1 mole of Acetyl CoA. However net ATP i.e after ETS which would make the answer to 12 ATP(9+2+1) respectively.

36 ATPs are produced in Aerobic Respiration involving the complete breakdown of glucose molecule into carbon-dioxide and water using oxygen as final electron aceptor

Complete oxidation of glucose molecule takes place in 3 sequential reactions -

1.Glycolysis occuring in cytoplasm

2.Kreb cycle occuring in mitochondrial matrix

3 Electron transport chain (ETC )and oxidative phosphorylation occuring in inner mitochondrial membrane . So,total number of ATPs produced in aerobic respiration are

Glycolysis - 6/8 ATPs

Link reaction and kreb cycle - 30ATPs

Total -36/38 ATPs.


So, the correct option is 'Option A'.

Which of the following steps of respiration is amphibolic?
  1. Glycolysis

  2. Oxidative decarboxylation of pyruvate

  3. TCA cycle

  4. Oxidative phosphorylation


Correct Option: C
Explanation:

TCA or Krebs' cycle is amphibolic (both catabolic and anabolic) because it provides a number of intermediates for anabolic pathways.

Mechanism of aerobic respiration was discovered by

  1. Kreb

  2. Calvin

  3. Hatch and Slack

  4. Pasteur


Correct Option: A
Explanation:

Mechanism of aerobic respiration was given by Kreb. Thus it was named as Krebs cycle. Aerobic respiration is the respiration, which involves the breakdown of the substrate in the presence of oxygen (oxidation process).

Which one of the following reactions is an example of oxidative decarboxylation?

  1. Conversion of succinate to fumarate.

  2. Conversion of fumarate to malate.

  3. Conversion of pyruvate to acetyl Co-A.

  4. Conversion of citrate to isocitrate.


Correct Option: C
Explanation:

The conversion of pyruvate to acetyl-CoA is a linker step between glycolysis and Krebs cycle. After the entry of pyruvate in the mitochondria the acetylation takes place in the perimitochondrial space which is the space between the inner and outer mitochondrial membrane. Each molecule of pyruvic acid is oxidatively decarboxylated to acetyl coA by the action of an enzyme complex pyruvate dehydrogenase. The acetyl coA then enters the Krebs cycle.  Thus the correct answer is option C.

The importance of the Kreb's cycle is 

  1. Production of amino acid

  2. Production of vitamin

  3. Production of ATP molecule through oxidative phosphorylation

  4. ATP formation through oxidative and substrate level phosphorylation


Correct Option: D
Explanation:

The pyruvic acid enters Krebs cycle in form of acetyl CoA where it is oxidatively decarboxylated into CO$ _2$. The complete Kreb cycle leads to the net formation of 2 molecules of ATP by substrate-level phosphorylation, 8 molecules of NADH plus 2 molecules of FADH$ _2$ (via succinate dehydrogenase). The NADH and FADH$ _2$ then enter the ETS to drive ATP production by substrate level phosphorylation. 

So, the correct answer is option D.

An amphibolic pathway is

  1. TCA cycle

  2. Calvin cycle

  3. Terminal oxidation

  4. Electron transport chain


Correct Option: A
Explanation:

Kreb's cycle consists of 8 cyclic steps which take place in the mitochondrial matrix. Each step is catalyzed by a specific enzyme. In Kreb's cycle, the entrant molecule is 2- carbon acetyl coenzyme A and the receptor molecule is 4- carbon oxaloacetate. Since the process involves both catabolic and anabolic reactions. it is an amphibolic pathway. It degrades acetyl coenzyme A and yields carbon dioxide and energy which is used to produce NADH, H+, and FADH+

Thus, the correct answer is option A. 

Mitochondria is the site for

  1. Krebs cycle

  2. Calvin cycle

  3. Anaerobic respiration

  4. Trapping of sun light


Correct Option: A
Explanation:
  • The citric acid cycle is also known as the TCA cycle (tricarboxylic acid cycle) or the Krebs cycle. 
  • It is a series of chemical reactions used by all aerobic organisms to release stored energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins, into adenosine triphosphate (ATP) and carbon dioxide.
  •  In eukaryotic cells, the citric acid cycle occurs in the matrix of the mitochondrion.
  •  In prokaryotic cells, such as bacteria, which lack mitochondria, the citric acid cycle reaction sequence is performed in the cytosol. 
  • Hence, Mitochondria is the site for the Krebs cycle.
  • So, the correct answer is 'Krebs cycle'.

Each molecule of pyruvic acid entering the Kreb's cycle produces.

  1. $2$ molecules of $CO _{2}$

  2. $3$ molecules of $CO _{2}$

  3. $1$ molecules of $CO _{2}$

  4. $5$ molecules of $CO _{2}$


Correct Option: A
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