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Antibiotics and their uses - class-XI

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Penicillin was first discovered by 

  1. Alexander Fleming

  2. Robert Koch

  3. S. Waksman

  4. Max Theiler


Correct Option: A
Explanation:

Sir Alexander Fleming, a Scottish researcher, is credited with the discovery of penicillin in 1928.

So the above-selected option is correct. 

Pencillin is given to a patient in order to

  1. Cure hereditary disease

  2. Cure all diseases

  3. Prevent any rise in bodily temperature

  4. Prevent the growth of several types of disease causing bacteria


Correct Option: D
Explanation:
Peptidoglycan is a major component of most bacterial cell walls. Penicillin prevents peptidoglycan from cross-linking properly in the last stages of bacterial cell wall synthesis. This greatly weakens the cell wall and causes the bacterium to lyse, or burst open, because of osmotic pressure. Penicillin is bactericidal because it directly kills bacteria. Hence, it is used to prevent the growth of disease causing bacteria.

Alexander Fleming discovered penicillin in 1928, while working with

  1. Streptomyces

  2. Bacteria (Staphylococcus)

  3. Penicillium notatum

  4. P. chrysogenum


Correct Option: B
Explanation:

In 1928, Alexander Fleming was investigating the properties of Staphylococci. One day, he observed that the culture of Staphylococci was contaminated with fungus and that colonies of the culture surrounding the fungus had been destroyed. 
Fleming grew the mold in a pure culture and found that it produce a substance that killed a number of disease-causing bacteria. He identified the mold (fungus) as being from the Penicillium genus and named the substance it released Penicillin. He investigated its positive antibacterial effect on many organisms and noticed that it affected bacteria such as Staphylococci and many other Gram-positive pathogens that cause scarlet fever, pneumonia, meningitis, diphtheria but not typhoid fever caused by Gram-negative bacteria.

Therefore, the correct answer is option B.

Penicillin was discovered by

  1. Fleming

  2. Waksman

  3. Burkholder

  4. Dubois


Correct Option: A
Explanation:

Penicillin is a group of antibiotics derived from Penicillium fungi. The discovery of penicillin is attributed to Alexander Flemming in 1928.
Salman Waksman discovered streptomycin
Burkholder discovered Pfiesteria, which is a genus of heterotrophic dinoflagellates
Eugene Dubois was the first person to ever deliberately search for fossils of human ancestors
So, the correct answer is 'Fleming'

Who coined the term antibiotics?

  1. Flemming

  2. Florey

  3. Chain

  4. S. Waksman


Correct Option: D
Explanation:

Selman Waksman, the microbiologist who discovered streptomycin, first used the word "antibiotic" in 1943. 

The fungus contaminant of Staphylococcus culture of Fleming was

  1. Aspergillus flavus

  2. Claviceps purpurea

  3. Penicillium notatum

  4. Penicillium chrysogenum


Correct Option: C
Explanation:
  • Alexander Fleming was working on a Bacterial culture of Staphylococcus to studying the action of lysozyme and its role in the fighting of the infection.
  • While he was working with the culture he noticed that the bacterial culture's growth is inhibited due to the growth of fungal infection on it.
  • The fungus that infected the culture was  Penicillium notatum , whose secretion was later to be discovered as antibiotic penicillin.
  • So the answer Penicillium notatum is correct.

The cultures of Alexander Fleming consisted of

  1. Streptococcus

  2. Staphylococcus

  3. Bacillus

  4. Clostridium


Correct Option: B
Explanation:
  • Alexander Fleming was working with a bacteria to study the action of lysozyme and its role in the fighting of the infection in the human body.
  • The bacterial culture that he was working on was of Staphylococcus 
  • Due to some fault, the bacterial culture Fleming was working on developed a fungal infection of Penicillium notatum which inhabited the growth of the bacteria in the culture.
  • The secretion which was released by the fungus was called mold juice by Fleming but later he named it as penicillin after the name of the organism which secretes it.
  • So the answer Staphylococcus is correct.

Penicillin will be unaffective against ___________________.

  1. Mycoplasma, Slime moulds and Psedomonas

  2. Staphyloccus, Mycoplasma & Animal cell

  3. Slime moulds, Aspegillus & Psedomonas

  4. Mycoplasma, Animal cell & Slime moulds


Correct Option: A

Fleming discovered Penicillin from

  1. Penicillium notatum

  2. P. roqueforti

  3. P. camemberti

  4. P. chryaogenum


Correct Option: A
Explanation:
  • Discovery of penicillin antibiotic by Fleming was an accidental discovery.
  • Fleming was working with different bacterial strains to study the effect of lysozyme in fighting of bacterial infection in human body.
  • In his lab there were many petri dish containing different strains of bacteria, he observed that one of the petridishes containing the strain for bacteria  Staphylococcus was infected by the growth of a fungus
  • This fungus growing along with the bacterial colony inhibited the growth of the bacterial colony
  • On further observation Fleming saw that the chemical substances secreted by the mold inhibited the bacterial growth. He named it Penicillin after the name of the organism ie Penicillium notatum
  • So, the correct answer is Penicillium notatum 

In 1928, a scientist discovered the first effective antibiotic. Scientist and antibiotics are

  1. Fleming - Streptomycin

  2. Fleming - Penicillin

  3. Waksman - penicillin

  4. Waksman - streptomycin.


Correct Option: B
Explanation:
  • In September 1928 when Alexander Fleming observed his Petri dishes of the bacterial culture he notice that the culture of bacteria Staphylococcus has a mold growing over it which has inhabited its growth in that area.
  • Upon observing he found that the mold was a strain of fungus Penicillium notaum and its was secreting some substance which inhibited the growth of the bacteria.
  • He named it penicillin after the organism from which it is secreted.
  • So the answer Alexander Fleming who discovered the first antibiotic penicillin is correct.

Ernest Chain and Howard Florey's contribution was.

  1. Discovery of streptokinase

  2. Establishment of potential of penicillin as effective drug

  3. Discovery of DNA sequences

  4. Isolating the bacterial plasmid

  5. Production of genetically engineered insulin


Correct Option: B

The culture and fungal invader in discovery of penicillin by Alexander Fleming are

  1. Vibrio cholerae and Penicillium requeforti

  2. Staphylococcus aureus and Penicillium notatum

  3. Eacherichia coli and Penicillium chrysogenum

  4. Clostridium tetani and Penicillium chrysogenum


Correct Option: B
Explanation:

The discovery of Penicillin was a case of serendipity and it was observed on a culture plate of Staphylococcus aureus that was contaminated by a fungus species. 

So, the correct option is "Staphylococcus aureus and Penicillium notatum".

Choose the correct combination.

a Walter Sutton $1$ Discovered penicillin
b Thomas Hunt Morgan $2$ Discovered chromosomal basis of heredity
c James Watson $3$ Described the phenomenon of linkage and crossing over
d Alexander Fleming $4$ Discovered double helical structure of DNA
  1. a-$1$, b-$4$, c-$2$, d-$3$

  2. a-$2$, b-$3$, c-$1$, d-$4$

  3. a-$3$, b-$2$, c-$1$, d-$4$

  4. a-$2$, b-$3$, c-$4$, d-$1$

  5. a-$4$, b-$1$, c-$2$, d-$3$


Correct Option: D
Explanation:

  • Sutton deduced that chromosomes are the basis of heredity and that the reduction of chromosomes in meiosis is directly related to Mendel's laws of inheritance.
  • Thomas Hunt Morgan described the phenomenon of linkage and crossing over. Morgan imagined that genes on chromosomes were similar to pearls on a string, in other words, they were physical objects. The closer two genes were to one another on a chromosome, the greater their chance of being inherited together. In contrast, genes located farther away from one another on the same chromosome were more likely to be separated during recombination. Therefore, Morgan correctly proposed that the strength of linkage between two genes depends upon the distance between the genes on the chromosome. This proposition became the basis for construction of the earliest maps of the human genome.
  • James Dewey Watson discovered the structure of DNA in 1953 with Francis Crick.
  • Scottish bacteriologist Alexander Fleming accidentally discovered the antibiotic in 1928, when he came back from a vacation and found that a green mold called Penicillium notatum had contaminated Petri dishes in his lab and were killing some of the bacteria he’d been growing.

So, the correct answer is 'a-2, b-3, c-4, d-1'.

Which of the following statement is incorrect about antibiotics?

  1. Coined by Waksman (1942)

  2. Produced by microorganisms

  3. Produce allergy in some persons

  4. Cure all diseases


Correct Option: D
Explanation:

Antibiotic is a medicine which inhibits the growth of microbes. This term was coined by Selman Waksman. They are produced by many bacteria, fungi, and other microorganisms. Some of them increase the activity of mast cell resulting into allergy. They are specific for the disease.

So, the correct answer is 'Cure all diseases'

Match the following and find the correct option.

I II
(a) Cristian Haneen (i) Vaccination
(b) Waksman (ii) Penicillin
(c) Edward Jenner (iii) Purification of enzyme zennet
(d) Alaxander Fleming (iv) streptomycin
  1. a-iv, b-i, c-ii, d-iii

  2. a-iii, b-i, c-iv, d-ii

  3. a-iii, b-ii, c-i, d-iv

  4. a-iii, b-iv, c-i, d-ii


Correct Option: D
Explanation:

(A)Cristian Haneen verified the Purification of enzyme zennet.

(B)Waksman discovered Streptomycin.
(C)Edward Jenner discovered Vaccination.
(D)Alexander Fleming discovered Penicillin.
So, the correct option is 'a-iii, b-iv, c-i, d-iii'.

The term antibiotic was coined by

  1. Fleming

  2. Waksman

  3. Funk

  4. Jenner


Correct Option: B
Explanation:

Selman Waksman, the microbiologist who discovered streptomycin, first used the word "antibiotic" in the medical sense in 1943. 

So the correct answer is 'Waksman'

Which of the following statement is correct?

  1. Activated sludge is digested by anaerobic bacteria to produce marsh gas.

  2. Aspergillus niger produces cyclosporin A.

  3. Fleming, Chain and Florey were awarded Nobel Prize for discovering penicillin.

  4. BOD is amount of oxygen produced by bacteria during decomposition.


Correct Option: C

Which of the following statements regarding antibiotics is not correct?


i) Antibiotic is the attenuated microorganisms which in small concentrations, can kill or retard the growth of other harmful microorganisms.
ii) Penicillin was the first antibiotic to be discovered by Alexander Fleming (1928) while working on bacterium Staphylococcus aureus.
iii) The full potential of penicillin as an effective antibiotic was established by Ernest Chain and Howard Florey.
iv) Fleming, Chain, and Florey were awarded the Nobel Prize in 1945.

  1. (i) Only

  2. (iii) Only

  3. (ii) and (iv)

  4. (i), (iii) and (iv)


Correct Option: A
Explanation:
  • Antibiotics are antimicrobials that are released by bacteria, fungi or molds naturally or are synthesized artificially that are capable of killing or inhibiting competing microbial species. They are therefore antimicrobial substances and not entire microorganisms that are used. 
  • In 1928 penicillin, the first true antibiotic was discovered by Alexander Fleming from colonies of Staphylococcus bacteria. However, its full potential as an antibiotic was established by Florey and Chain. Howard Florey, Ernst Chain, and Sir Alexander Fleming received the Nobel prize for their work on penicillin in 1945. 
  • So, the correct answer is '(i) only'.

Penicillin kills bacteria by ________________.

  1. Suppression of clef-wall synthesis

  2. Lyses of protoplasm

  3. Interfering with RNA synthesis

  4. Inhibiting DNA synthesis


Correct Option: A

Name an antibiotic manufactured from fungi.

  1. Penicillin

  2. Streptomycin

  3. Amoxicillin

  4. Ampicillin


Correct Option: A
Explanation:

Penicillin, one of the first and still one of the most widely used antibiotic agents, derived from the Penicillium mold. Streptomycin is produced from Streptomyces griseus bacteria. Ampicillin and Amoxicillin are synthetic antibiotics. So the above-selected option is correct 

Match column-I with Column-II and select the option having correct matching.

Column-I Column-II
A. Streptokinase i. Penicillium notatum
B. Statins ii. Monascus purpureus
C. Cyclosporin-A iii. Streptococcus
D. Penicillin iv. Trichoderma
  1. A-i, B-ii, C-iii, D-iv

  2. A-iii, B-ii, C-i, D-iv

  3. A-iii, B-ii, C-iv, D-i

  4. A-iv, B-ii, C-iii, D-i


Correct Option: C

An antibiotic such as penicillin

  1. Kills pathogenic bacteria

  2. Prevents pathogenic bacteria from reproducing

  3. Works against infectious viruses

  4. Inhibits the reproduction of retroviruses

  5. Both A and B


Correct Option: E
Explanation:
Antibiotics function by blocking vital processes in bacteria, killing the bacteria, or stopping them from multiplying. This helps the body's natural immune system to fight the bacterial infection. Antibiotics that affect a wide range of bacteria are called as broad spectrum antibiotics (e.g., amoxicillin and gentamicin). Antibiotics that affect only a few types of bacteria are called as narrow-spectrum antibiotics (e.g., penicillin). Penicillin is bactericidal. A bactericidal antibiotic usually either interferes with the formation of the bacterium's cell wall or its cell contents. A bacteriostatic antibiotic stops bacteria from multiplying. An antibiotic is given for the treatment of an infection caused by bacteria. Antibiotics target microorganisms such as bacteria, fungi and parasites. However, they are not effective against viruses.

The wonder drug penicillin was discovered by

  1. Louis Pasteur

  2. Alexander Fleming

  3. Edward Jenner

  4. Jonas Salk


Correct Option: B
Explanation:

Penicillin was discovered in London in September of 1928 by Dr. Alexander Fleming, the bacteriologist on duty at St. Mary’s Hospital. The discovery of penicillin has often been described as a miracle drug because prior to the discovery of penicillin, death could occur in very trivial injuries and diseases.

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