Nucleic Acids
| Description: gate | |
| Number of Questions: 15 | |
| Created by: Rani Rajan | |
| Tags: Nucleic Acids GATE Zoology Biochemistry and Molecular Biology Verbal Reasoning |
Which of the following nucleic acids is a 25 mer DNA antisense oligonucleotide therapeutic inhibiting insulin receptor substrate-1?
Assertion (A): The G-quadruplexes are formed in nucleic acids by sequences that are rich in guanine. Reason (R): The interaction between G5 and G21 is a 90-degree turn between the G-qudruplex and duplex motifs.
Which of the following statements is/are false?
- In sequence assembly, k-mers are normally used during the construction of De Bruijn graphs.
- The choice of the k-mer size has many different effects on the sequence assembly.
- A lower k-mer size will increase the amount of edges stored in the graphs and decrease the amount of space required to store DNA sequence.
Which of the following statements is/are correct about anti-thrombin aptamers?
P. These are G-quadruplex-bearing polynucleotides. Q. They show poor affinity and specificity against thrombin. R. They are bound to the exosite I of thrombin majorly via their two TT loops through polar and hydrophobic interactions.
Which of the following identical sequences occur(s) within nucleic acid sequences, peptide sequences, protein structures and carbohydrates across different species?
Which of the following is a type of oligomer molecule used in molecular biology to modify gene expression?
Which of the following is a polymer identical to DNA or RNA but differing in the composition of its backbone?
Assertion (A): Purines are complementary only with pyrimidines, where pyrimidine-pyrimidine pairing is energetically unfavorable. Reason (R): The molecules are too far apart for H-bonding to be formed.
Assertion (A): The translation of genetic information implied in mRNA into a protein is catalysed by ribosomes. Reason (R): Each three nucleotide codon is translated into one of twenty naturally occurring amino acids.
Which of the following statements about nucleic acid metabolism is/are incorrect?
A. Nucleotide preparation is an anabolic mechanism involving the chemical reaction of phosphate, pentose sugar and nitrogenous base. B. In purine synthesis, phosphoribosyl pyrophosphate is turned into inosine triphosphate. C. Both synthesis and degradation reactions require enzymes.
Which of the following exists between two nucleotides in RNA molecules that do not follow Watson-Crick base pair rules?
- Wobble base pair
- Hoogsteen base pair
- UCbase
Which of the following nucleic acids is a type of oligomer molecule used in molecular biology to modify gene expression?
Which of the following is a synthetic alternative to the natural nucleic acids DNA and RNA as an information-storing biopolymer?
Assertion (A): Most biological substrates lose their biological function when denatured. Reason (R): The denaturing process and the associated loss of activity can be measured using techniques like dual polarisation interferometry.
Match the following.
| Column – I | Column – II |
| A. Peptide nucleic acid | 1. Modified RNA nucleotide synthesised by the group of Jesper Wengel |
| B. Locked nucleic acid | 2. Artificial genetic polymer invented by Albert Eschenmoser |
| C. Threose nucleic acid | 3. Artificially synthesised polymer similar to DNA or RNA invented by Peter E. Nielsen |