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Human Genetics and Origin of Life

Description: This test will help the students to revise their topics thoroughly and thus will help them in preparing for their exams in better way.
Number of Questions: 15
Created by:
Tags: Evolution Origin of Life Theories of Origin of Life Translation Gene Expression and Regulation Regulation of Gene Expression DNA Replication Replication of DNA
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The oldest microfossil of age 3.6 billion year ago was

  1. the Coacervates

  2. the Vesicle

  3. the Cyanobacteria

  4. the Protocell

  5. the Microspheres


Correct Option: C
Explanation:

Cyanobacteria are ubiquitous environmental bacteria that have important roles in geochemical events, such as the early oxygenation of the atmosphere. Microfossils found in Australia show that more than 3.6 billion years ago, cynobacteria thrived on an Earth that had no oxygen.

Which among the following is not a vestigial structure present in human beings?

  1. Caecum

  2. Orbitalis muscle

  3. Plica semilunaris

  4. Darwin's tubercle

  5. Rectum


Correct Option: E
Explanation:

The rectum is the concluding part of the large intestine that terminates in the anus. The rectum stores solid waste until it leaves the body through the anus.

Which of the following semiessential amino acids is encoded by six different codons in humans?

  1. Serine

  2. Leucine

  3. Arginine

  4. Tryptophan

  5. Methionine


Correct Option: C
Explanation:

Arginine is an α-amino acid. At the level of molecular genetics, in the structure of the messenger ribonucleic acid mRNA, CGU, CGC, CGA, CGG, AGA, and AGG, are the triplets of nucleotide bases or codons that code for arginine during protein synthesis. In mammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual.

A living fossil is an organism which has retained the same form over millions of years. The living fossil considered as the connecting link between pisces and amphibia is ___________.

  1. peripatus

  2. monotremes

  3. seymouria

  4. lungfish

  5. coelacanth


Correct Option: E
Explanation:

The coelacanth is a living fossil. Unlike any other living animal, coelacanths have a hinged joint in the skull, which allows the front part of the head to be lifted whilst feeding. They also have limb-like, lobed pectoral and pelvic fins and a unique tail consisting of three distinct lobes. They are considered as the connecting link between pisces and amphibia.

Which of the following statements regarding the process of translation in organisms is INCORRECT?

  1. The basic process of protein production is addition of one amino acid at a time to the end of a protein.

  2. Each amino acid added is matched to a three nucleotide subsequence of the mRNA.

  3. The ribosome molecules translate this code to a specific sequence of amino acids.

  4. The mRNA carries genetic information encoded as a ribonucleotide sequence from the chromosomes to the ribosomes.

  5. The basic process of protein production is addition of an amino acid occurs at the N-terminus of the peptide.


Correct Option: E
Explanation:

Addition of an amino acid occurs at the C-terminus of the peptide and thus translation is said to be amino-to-carboxyl directed.

In biology the process of coextinction is described as the simultaneous extinction of two or more species (especially when one is dependent on the other). Which of the following statements does NOT characterises coextinction of the species?

  1. Losses of parasites can have positive impacts on humans or the other species.

  2. Coextinction may also occur on a local level.

  3. The loss of parasites can reduce host diversification rates.

  4. The area with that has the greatest affect of coextinction is the tropics.

  5. The host specificity and life cycle is a major factor in the risk of coextinction.


Correct Option: A
Explanation:

One main consequence of coextinction that goes beyond biodiversity is mutualism, by loss of food production with a decline in threatened pollinators. Losses of parasites can have negative impacts on humans or the other species.

There are numerous techniques in cytogenetics to investigate the different features of chromosomes within a cell. Which of the following is a frequently used fluorescent pattern acquired employing quinacrine for staining the chromosomes?

  1. C-banding

  2. R-banding

  3. G-banding

  4. Q-banding

  5. T-banding


Correct Option: D
Explanation:

Q-banding is a fluorescent pattern obtained using quinacrine for staining. The pattern of bands is very similar to that seen in G-banding. They can be recognised by a yellow fluorescence of differing intensity. Most part of the stained DNA is heterochromatin. Quinacrin (atebrin) binds both regions rich in AT and in GC, but only the AT-quinacrin-complex fluoresces.

Which of the following histone proteins is significant in identifying the complete structure of chromatin?

  1. Histone H1

  2. Histone H2A

  3. Histone H2B

  4. Histone H3

  5. Histone


Correct Option: B
Explanation:

H2A is important for packaging DNA into chromatin. Since, H2A packages DNA molecules into chromatin, the packaging process will effect gene expression. H2A has been correlated with DNA modification and epigenetics. H2A plays a major role in determining the overall structure of chromatin.

A gene whose expression varies according to the environmental change is known as __________.

  1. a constitutive gene

  2. a facultative gene

  3. an inducible gene

  4. a housekeeping gene

  5. an oscillating gene


Correct Option: C
Explanation:

An inducible gene is a gene whose expression is either responsive to environmental change or dependent on the position in the cell cycle.

Which among the following statements regarding the vestigial organs is incorrect?

  1. Vestigial traits can still be considered adaptations.

  2. Vestigial structures are often heterologous to structures that are functioning normally in other species.

  3. There are also vestigial molecular structures present in humans.

  4. The formation of goose bumps in humans under stress is a vestigial reflex.

  5. The human caecum is a vestigial organ.


Correct Option: B
Explanation:

Vestigial structures are often homologous to structures that are functioning normally in other species. Therefore, vestigial structures can be considered evidence for evolution, the process by which beneficial heritable traits arise in populations over an extended period of time.

Which of the following types of oscillating gene present in plants regulates the expression of CAB?

  1. Toc1 gene

  2. The LHY gene

  3. The CCA1 gene

  4. Kai genes

  5. Frq gene


Correct Option: A
Explanation:

Toc1 gene, also known as Timing of CAB Expression 1 gene, is an oscillating gene found in the plants that is known to control the expression of CAB. It has been shown to affect the period of circadian rhythms through its repression of transcription factors. This was found through mutations of toc1 in plants that had shortened period of CAB expression.

Centromere proteins are a group of proteins, which either form or mediates the function of centromeres. Which of the following centromere proteins is predominately essential for keeping proper kinetochore size?

  1. Centromere protein

  2. Centromere protein B

  3. Centromere protein C 1

  4. Centromere-associated protein E

  5. Centromere protein F


Correct Option: C
Explanation:

Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12.

Which of the following types of genes is a transcription factor in the circadian pacemaker of mammal's heart particularly human beings?

  1. Bmal1 gene

  2. Clock gene

  3. Per gene

  4. Tim gene

  5. Cycle gene


Correct Option: B
Explanation:

Clock, also known as Circadian Locomotor Output Cycles Kaput, is a transcription factor in the circadian pacemaker of mammals. It affects both the persistence and period of circadian rhythms by its interactions with the gene Bmal1.

Various retro viruses incorporates their genetic material into host chromosomes. Which of the following is used by viruses to insert their genetic material into the host genomes?

  1. Inverted repeat

  2. Direct repeats

  3. Long terminal repeats

  4. Tandem repeats

  5. Interspersed repetitive


Correct Option: C
Explanation:

Long terminal repeats are identical sequences of DNA that repeat hundreds or thousands of times found at either end of retrotransposons or proviral DNA formed by reverse transcription of retroviral RNA. They are used by retro viruses to insert their genetic material into the host genomes.

Which of the following DNA repeats encodes a protein containing a leucine zipper motif?

  1. SINEs

  2. UTR

  3. Second ORF

  4. First ORF

  5. LTRs


Correct Option: D
Explanation:

The first ORF encodes a RNA-binding protein of 500 amino acid lengths that weighs 40 kDA. This protein contains a leucine zipper motif and functions as a chaperone.

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