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Molecular Biology

Description: Molecular biology test for entrance examination in bio-informatics and bio-chemistry
Number of Questions: 25
Created by:
Tags: Nucleic Acid Chemistry Proein Synthesis Operon Nucleic Acid Chemistry Inorganic Chemistry Organic Chemistry
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Which of the following genes is expressed at a constant rate, without being subjected to regulation?

  1. Gratuitous inducer gene

  2. Repressor gene

  3. Constitutive gene

  4. Oncogene

  5. Protooncogene

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Correct Option: C

The step that initiates the process of 'Southern Blot Technique' is

  1. fragmentation of DNA by restriction of endonucleases

  2. electrophoresis of cut pieces on agarose gel

  3. isolation of DNA from suspected cell

  4. denaturation of DNA by treating it with NaOH

  5. transfer to a membrane

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Correct Option: C

Which of the following is used for detecting the antibodies against HIV?

  1. ELISA

  2. FISH

  3. Western blot

  4. Northern blot

  5. Southern blot

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Correct Option: C

Overexpression of Myc protein occurs in

  1. Burkitt's lymphoma

  2. CML

  3. breast cancer

  4. acute lymphoblastic leukemia

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Correct Option: A
Explanation:

Burkitt's lymphoma is caused by over expression of myc gene.

Which of the following malignancies is due to the chromosomal translocation?

  1. Lung cancer

  2. Chronic lymphoblastic leukemia

  3. Acute myelocytic leukemia

  4. Chronic myelogenous leukemia

  5. Bladder cancer

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Correct Option: D

Which of the following is the the application of antisense therapy?

  1. In the treatment of acute leukaemia, HIV infection and papilloma virus infection

  2. In the establishment of parenthood of a child

  3. In the prenatal diagnosis of genetic disease

  4. In detecting infectious agents in tissue

  5. Isolating viruses

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Correct Option: A

Which of the following processes is carried out during the preparation of chimeric DNA?

  1. Specific gene is isolated and amplified.

  2. Plasmids are replicated independently from bacterial DNA.

  3. Restriction endonuclease and human DNA are incubated together for annealing.

  4. Gene of interest & plasmid are cut with two different restriction enzymes.

  5. Restriction enzymes help in joining two DNA molecules.

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Correct Option: A

Translation of mRNA into a ribosome proceeds _______.

  1. from the 3' end to the 5' end

  2. from the 5' end to the 3' end

  3. from the middle to the 3' end and then from the middle to the 5' end

  4. from either the 5' or 3' end, depending on the enzymes present

  5. from the middle simultaneously toward the 3' and 5' ends

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Correct Option: B

The shift of mRNA by 3 nucleotides in order to bring another codon into position in the ribosome is called ______.

  1. translocation

  2. transformation

  3. packaging

  4. transcription

  5. transport

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Correct Option: A

In prokaryotes, the initiation codon for protein synthesis is normally _____.

  1. UUC

  2. AAG

  3. UGA

  4. AUG

  5. UAC

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Correct Option: D

In the function of the lac operon in E. coli, the lac genes are transcribed in the presence of lactose because

  1. RNA polymerase binds to the operator

  2. the repressor binds to the promoter

  3. an isomer of lactose binds to the repressor

  4. CAP does not bind to the operator

  5. of the absence of cAMP

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Correct Option: C

When tryptophan is present in the environment of E. coli, the tryptophan binds to the

  1. trp operon

  2. trp promoter

  3. trp operator

  4. trp repressor

  5. trp polymerase

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Correct Option: D

The operon that controls tryptophan producing genes in E. coli consists of _______________.

  1. only one gene

  2. two genes

  3. three genes

  4. four genes

  5. five genes

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Correct Option: A

Which of the following vectors has the highest DNA insert capacity?

  1. Plasmids

  2. Phages

  3. Cosmids

  4. Yeast artificial chromosomes

  5. Bacterial artificial chromosomes

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Correct Option: D

Which of the following viruses is used for cancer gene therapy?

  1. Retro virus

  2. Adeno virus

  3. AAV

  4. Herpes simplex virus

  5. None of the above

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Correct Option: D

Restriction enzymes that produce staggered cuts known as “sticky ends” are useful because

  1. sticky ends stick to almost anything

  2. sticky ends allow fragment ends to reanneal, which is usually desirable

  3. DNA fragments, cut with the same enzyme, can anneal to each other

  4. staggered cuts won't join with other DNA fragments regardless of how they were cut

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Correct Option: C

________ are used to select genes of interest from a genomic library.

  1. Restriction enzymes

  2. Cloning vectors

  3. DNA probes

  4. Gene targets

  5. Antibodies

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Correct Option: C

Which of the following is a purine?

  1. Adenine

  2. Cytosine

  3. Uracil

  4. Thymine

  5. None of these

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Correct Option: A

A nasal spray containing adenovirus carrying a functional human CFTR gene is used to treat cystic fibrosis. This is an example of ____ gene therapy.

  1. in situ

  2. in vivo

  3. ex vivo

  4. vaccine

  5. germ line

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Correct Option: B

The nitrogenous base which pairs with adenine in any given DNA molecule as per the Watson - Crick model is called

  1. guanine

  2. cytosine

  3. thymine

  4. uracil

  5. none of these

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Correct Option: C

Which of the following compounds is formed, when a ribose or deoxyribose of a nucleoside is phosphorylated?

  1. Nucleoside

  2. Tautomer

  3. Nucleotide

  4. Nucleic acid

  5. None of these

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Correct Option: C

Screening test for aneuploidy syndromes is

  1. Western blot

  2. Northern blot

  3. Southern blot

  4. FISH

  5. ELISA

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Correct Option: D

Which of the following is an example of the degeneracy of the genetic code?

  1. A given amino acid has more than one codon

  2. Each codon specifies more than one amino acid

  3. The first two bases specify the amino acid

  4. The genetic code is not degenerated

  5. None of these

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Correct Option: A

Dicumarol acts by inhibiting which of the posttranslational modifications?

  1. Glycosylation

  2. Carboxylation

  3. Amidation

  4. Hydroxylation

  5. Phosphorylation

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Correct Option: B

The feature that best refers to the melting temperature of DNA is

  1. the temperature at which the entire DNA is denatured

  2. the length of DNA

  3. the proportion of G-C content of DNA

  4. the proportion of the purine content of DNA

  5. none of these

Show answer
Correct Option: C
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