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Bioinorganic Chemistry

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Pernicious anaemia is one of the obvious symptoms of _______ deficiency.

  1. cobalt

  2. magnesium

  3. calcium

  4. molybdenum

  5. nickel


Correct Option: A
Explanation:

Pernicious anaemia is one of the obvious symptoms of a cobalt deficiency.

Which of the following are examples of iron-sulphur proteins?

  1. Rubredoxin
  2. Methane monooxygenase
  3. Rieske proteins
  4. Aconitase
  1. 1 and 2

  2. 1, 2 and 3

  3. 1, 3 and 4

  4. 2 and 3

  5. 2, 3 and 4


Correct Option: C
Explanation:

This option is correct because Rubredoxin is a small iron-sulphur protein found in various sulphur-metabolizing bacteria, Rieske proteins are iron-sulphur protein components of cytochrome bc1 complexes and cytochrome b6f complexes which were first discovered and isolated by John S. Rieske and co-workers in 1964 and Aconitase is an iron-sulphur protein that catalyses the interconversion of citrate and isocitrate

The element present in budotitane is ______

  1. Co

  2. Mo

  3. Sn

  4. As

  5. Ti


Correct Option: C
Explanation:

Sn (Tin) is present in budotitane and is used to treat cancer. So, this is the correct option.

Which of the following sets represents micronutrients?

  1. Na, Ca, P, Cl, Fe

  2. Mn, Cu, Zn, Mo, Se

  3. Ca, Fe, Mn, Zn, Mo

  4. P, Cl, Cu, Zn, Mo

  5. Mn, Ca, P, Zn, Fe


Correct Option: B
Explanation:

Micronutrients are nutrients required by humans and other organisms throughout life in small quantities to orchestrate a range of physiological functions. Examples: Mn, Co, Ni, Cu, Zn, V, Cr, Mo, Se, F, I, Al, Pb, Sn and Si.

Which of the following is a selenium containing enzyme?

  1. Dopamine beta-hydroxylase

  2. Tyrosinase

  3. Carbonic anhydrase

  4. Urease

  5. Glutathione peroxidase


Correct Option: E
Explanation:

Selenium is an important constituent of the enzyme glutathione peroxidase, which is responsible for destroying lipid-damaging peroxides.

Which of the following is a copper transport protein?

  1. Ceruloplasmin

  2. Plastocyanin

  3. Hemocyanin

  4. Hemoglobin

  5. Myoglobin


Correct Option: A
Explanation:

Ceruloplasmin, a glycoprotein produced in the liver, carries or transports more than 95 percent of the copper in blood plasma.

Which of the following are biological functions of Mg+2?

  1. Present in chlorophyll and helps in photosynthesis
  2. Activation of enzymes
  3. Information carrier
  4. Osmotic balance
  1. 1 and 2

  2. 1, 2 and 3

  3. 1, 2 and 4

  4. 2 and 4

  5. 2, 3 and 4


Correct Option: B
Explanation:

This option is correct because Mg is present in chlorophyll and helps in photosynthesis, is helpful in activation of enzymes and also an Information carrier.

Which of the following are examples of copper containing enzymes?

  1. Carbonic anhydrases
  2. Urease
  3. Catechol dioxygenase
  4. Galactose oxidase
  1. Only 1

  2. 2 and 3

  3. Only 3

  4. 3 and 4

  5. Only 4


Correct Option: E
Explanation:

This option is correct because galactose oxidase is a monomeric enzyme that contains a single copper ion and catalyses the stereospecific oxidation of primary alcohols to their corresponding aldehydes.

Which of the following matches of metalloenzyme and metal cofactors are incorrect? A. Tyrosinase: Copper B. Urease: Copper C. Dopamine β-hydroxylase: Nickel D. Catechol dioxygenase: Iron

  1. A and B

  2. A and D

  3. B and C

  4. B and D

  5. C and D


Correct Option: C
Explanation:

This option is correct because urease is a nickel-containing metalloenzyme of high molecular weight that catalyses the hydrolysis of urea into carbon dioxide and ammonia and dopamine β-hydroxylase is a copper-containing enzyme that synthesises norepinephrine from dopamine.

Which of the following is a tungsten containing metalloenzyme?

  1. Formaldehyde ferredoxin oxidoreductase
  2. Carboxypeptidase A
  3. Carbon monoxide dehydrogenase
  1. Only 1

  2. Only 2

  3. Only 3

  4. 1 and 2

  5. 2 and 3


Correct Option: A
Explanation:

Formaldehyde ferredoxin oxidoreductase is a tungsten containing metalloenzyme.

Which among the following is used as an anti copper agent in Hepatolenticular degeneration?

  1. Silver sulfadiazine

  2. Technetium

  3. Barium sulphate

  4. Selenium sulphide

  5. Tetrathiomolybdate


Correct Option: E
Explanation:

Correct option: Tetrathiomolybdate is used as an anti copper agent in Hepatolenticular degeneration.

Which of the following is used as an anti copper agent in Wilson’s disease?

  1. Silver sulfadiazine

  2. Technetium

  3. Barium sulphate

  4. Tetrathiomolybdate

  5. Selenium sulphide


Correct Option: D
Explanation:

Correct option: Tetrathiomolybdate is used as an anti copper agent in Wilson’s disease.

Most abundant element by atomic percent in human body is ______

  1. C

  2. O

  3. H

  4. N

  5. P


Correct Option: C
Explanation:

This option is correct because in an adult male human body water is approximately 57%. The water is 11% hydrogen by mass but 67% by count of atoms (i.e. 67 atomic percent). Thus, most of the mass of the human body is oxygen, but most of the atoms in the human body are hydrogen atoms.

Match entries in column I (elements) and Column II (their medical uses) and select the correct answer ||| |---|---| |Column I |Column II| |P. Selenium|1. Anti-dandruff| |Q. Magnesium|2. Antacid| |R. Antimony|3. Antileishmaniasis| |S. Tin|4. Anti-caries|

  1. P - 1, Q - 2, R - 3, S - 4

  2. P - 1, Q - 3, R - 2, S - 4

  3. P - 2, Q - 1, R - 4, S - 3

  4. P - 2, Q - 3, R - 1, S - 4

  5. P - 4, Q - 3, R - 2, S - 1


Correct Option: A
Explanation:

Selenium sulfide is used in anti-dandruff shampoos. Magnesium hydroxide is used as a laxative to relieve occasional constipation and as an antacid to relieve indigestion, sour stomach, and heartburn. Antimony compounds are used as antileishmaniasis agents such as sodium stibogluconate. Stannous fluoride is used as an anti-caries actives.

Match entries in column I (elements) and Column II (used in the treatment of) and select the correct answer ||| |---|---| |Elements |Used in the treatment of| |P. Li|1. Gastritis| |Q. Pt|2. Rheumatoid arthritis| |R. Au|3. Bipolar disorder| |S. Bi|4. Cancer|

  1. P - 4, Q - 2, R - 1, S - 3

  2. P - 3, Q - 4, R - 2, S - 1

  3. P - 2, Q - 3, R - 4, S - 1

  4. P - 1, Q - 4, R - 2, S - 3

  5. P - 1, Q - 3, R - 2, S - 4


Correct Option: B
Explanation:

Lithium salts are widely used to treat bipolar disorder (BPD). The square planar Pt(II) complex, cis-platin is used in the chemotherapy of cancer. Various gold compounds have been used in the treatment of rheumatoid arthritis. All are Au(I) complexes containing thiolate ligands. Bismuth salts are used in the treatment of gastritis.

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