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Biotechnology (GATE)

Description: Biotechnology Bioinformatics Biochemistry Microbiology GATE CSIR NET Biological Sciences BioinformaticsRecombinant DNA TechnologyCell Signaling and Signal TransductionBiochemistry
Number of Questions: 15
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Tags: Biotechnology Bioinformatics Biochemistry Microbiology GATE CSIR NET Biological Sciences Recombinant DNA Technology Cell Signaling and Signal Transduction
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____________ are examples of protein-protein interaction databases.

  1. BioGRID and Reactome

  2. STRING and SignaLink 2.0

  3. SignaLink 2.0 and Reactome

  4. BioGRID and STRING

  5. Reactome and STRING

Show answer
Correct Option: D
Explanation:

The Biological General Repository for Interaction Datasets (BioGRID) is a curated biological database of protein-protein and genetic interactions. STRING is a database of known and predicted protein interactions.

Which of the following pairs represents primary databases?

  1. SWISS-PROT and PROSITE

  2. SWISS-PROT and Genbank

  3. PROSITE and Genbank

  4. PROSITE and Pfam

  5. Genbank and Pfam

Show answer
Correct Option: B
Explanation:

Databases consisting of data derived experimentally, such as nucleotide sequences and three-dimensional structures, are known as primary databases. Examples: SWISS-PROT and Genbank

Identify the incorrect matching.

  1. PROSITE: Database of protein families and domains

  2. Reactome: Navigable map of human biological pathways

  3. BRENDA: Comprehensive enzyme information system

  4. PhenomicDB: Database linking human mutations with phenotype

  5. PRINTS: A compendium of protein fingerprints

Show answer
Correct Option: D
Explanation:

PhenomicDB is a multi-organism phenotype-genotype database including humans, mice, fruit flies, C.elegans and other model organisms.

Which of the following is an example of phylogenetic database?

  1. TRANSFAC

  2. RefSeq

  3. ModBASE

  4. TreeBASE

  5. InterPro

Show answer
Correct Option: D
Explanation:

TreeBASE is a repository of phylogenetic information.

________ is a bibliographic database.

  1. EMBL

  2. PDB

  3. Sequin

  4. BioOne

  5. ModBase

Show answer
Correct Option: D
Explanation:

BioOne bibliographic database is an indexed and fully-searchable collection of abstracts that link to the fulltext articles available from the BioOne organisation.

International Nucleotide Sequence Database (INSD) consists of which of the following?

  1. DNA Data Bank of Japan
  2. EMBL
  3. GenBank

  1. Only 1

  2. Only 3

  3. 1 and 2

  4. 2 and 3

  5. 1, 2 and 3

Show answer
Correct Option: E
Explanation:

International Nucleotide Sequence Database (INSD) consists of the following databases: DNA Data Bank of Japan (National Institute of Genetics) EMBL (European Bioinformatics Institute) GenBank (National Centre for Biotechnology Information)

International Nucleotide Sequence Database (INSD) consists of which of the following?

  1. DDBJ
  2. VectorBase
  3. European Nucleotide Archive
  4. PROSITE
  5. GenBank

  1. 1, 2 and 3

  2. 1, 3 and 5

  3. 2, 3 and 4

  4. 2, 3 and 5

  5. 3, 4 and 5

Show answer
Correct Option: B
Explanation:

The International Nucleotide Sequence Database Collaboration (INSDC) consists of a joint effort to collect and disseminate databases containing DNA and RNA sequences.

Identify the false statement(s).

  1. In mismatch correction repair, the parental DNA strand is distinguished from the daughter strand by acetylation.
  2. The basis for blue-white screening with pUC vectors is intraallelic complementation.
  3. Nude mice refers to mice without thymus.

  1. Only 1

  2. Only 2

  3. Only 3

  4. 1 and 2

  5. 1 and 3

Show answer
Correct Option: A
Explanation:

In mismatch correction repair, the parental DNA strand is distinguished from the daughter strand by methylation.The mismatch repair deals with correcting mismatch of the normal bases using BER or NER enzyme systems. 

Choose the correct signal transduction pathway.

a. Hormone b. 7TM receptor c. G protein d. cAMP e. PKA

  1. a → b → c → d → e

  2. a → c → b → d → e

  3. a → c → d → b → e

  4. a → b → c → e → d

  5. a → c → b → e → d

Show answer
Correct Option: A
Explanation:

The correct signal transduction pathway is: Hormone → 7TM receptor → G protein →  cAMP → PKA.

While searching a database for similar sequences, E value depends on all of the following, except

A. sequence length B. number of sequences in the database C. scoring system D. probability from a normal distribution

  1. A

  2. B

  3. B and C

  4. C

  5. C and D

Show answer
Correct Option: D
Explanation:

While searching a database for similar sequences, E value does not depend on scoring system.

Match the scientists in column I with their respective discoveries in column II.

 
Column I
Column II
P. Arber, Smith and Nathans 1. Restriction enzymes
Q. Sir Alec Jeffreys 2. Polymerase chain reaction
R. Kary Mullis 3. DNA fingerprinting
S. G. Kohler and C. Milstein 4. Hybridoma technology

  1. P - 1; Q - 2; R - 3; S - 4

  2. P - 1; Q - 3; R - 2; S - 4

  3. P - 2; Q - 1; R - 3; S - 4

  4. P - 2; Q - 3; R - 4; S - 1

  5. P - 3; Q - 2; R - 4; S - 1

Show answer
Correct Option: B
Explanation:

Correct matching is P - 1; Q - 3; R - 2; S - 4.

Match the entries in column I and column II and select the correct answer.

 
Column I
Column II
P. euGenes 1. Weizmann Institute of Science
Q. GeneCards 2. Indiana University
R. PIR 3. Georgetown University Medical Centre
S. ModBase 4. University of California at San Francisco

  1. P - 1; Q - 2; R - 3; S - 4

  2. P - 1; Q - 3; R - 2; S - 4

  3. P - 2; Q - 1; R - 3; S - 4

  4. P - 2; Q - 1; R - 4; S - 3

  5. P - 4; Q - 2; R - 1; S - 3

Show answer
Correct Option: C
Explanation:

Correct matching is P - 2; Q - 1; R - 3; S - 4.

Match the entries:

 
Group I
Group II
P. Glycogen phosphorylase 1. Selenium
Q. Glutathione peroxidase 2. Pyridoxal phosphate
R. Catalase 3. Heme
S. Pyruvate carboxylase 4. Biotin

  1. P - 1; Q - 2; R - 3; S - 4

  2. P - 1; Q - 3; R - 2; S - 4

  3. P - 2; Q - 1; R - 3; S - 4

  4. P - 2; Q - 1; R - 4; S - 3

  5. P - 3; Q - 2; R - 1; S - 4

Show answer
Correct Option: C
Explanation:

Correct matching is P - 2; Q - 1; R - 3; S - 4.

Match the entries in column I with those in column II.

 
Column I
Column II
P. MIT 1. Phosphatidylserine
Q. Annexin V 2. Microtubules
R. Methotrexate 3. Dihydrofolate reductase
S. Taxol 4. Succinate dehydrogenase

  1. P - 1, Q - 3, R - 4, S - 2

  2. P - 2, Q - 1, R - 4, S - 3

  3. P - 3, Q - 1, R - 4, S - 2

  4. P - 3, Q - 2, R - 4, S - 1

  5. P - 4, Q - 1, R - 3, S - 2

Show answer
Correct Option: E
Explanation:

Correct matching is P - 4, Q - 1, R - 3, S - 2.

Match the following:

 
Group I
Group II
P. Nalidixic acid 1. Topoisomerase
Q. Erythromycin 2. Peptide chain elongation
R. Cephalosporin 3. Peptidoglycan synthesis
S. Sulphonamide 4. Folic acid biosynthesis

  1. P - 1, Q - 2, R - 3, S - 4

  2. P - 2, Q - 1, R - 3, S - 4

  3. P - 4, Q - 1, R - 2, S - 3

  4. P - 3, Q - 4, R - 2, S - 1

  5. P - 3, Q - 4, R - 1, S - 2

Show answer
Correct Option: A
Explanation:

Correct matching is P - 1, Q - 2, R - 3, S - 4.

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