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Bioinformatics (GATE)

Description: GATE
Number of Questions: 15
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Tags: GATE Bioinformatics Major Bioinformatics Resources (NCBI, EBI, ExPASy) Sequence and Structure Databases
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An endoribonuclease that specifically degrades the RNA strand in RNA-DNA hybrids is

  1. RNase A

  2. RNase H

  3. RNase L

  4. RNase P

  5. RNase R

Show answer
Correct Option: B
Explanation:

This option is correct because Ribonuclease H (RNase H) is an endoribonuclease that specifically degrades the RNA strand in RNA-DNA hybrids.

Which of the following statements is not correct?

  1. rRNA is the most abundant type of RNA in a cell.

  2. Anticodon occurs in mRNA.

  3. Okazaki fragments are formed during replication.

  4. Nonsense codons do not code for any amino acid.

  5. DNA replication is semiconservative.

Show answer
Correct Option: B
Explanation:

This option is correct because anticodon is a sequence of three adjacent nucleotides in transfer RNA (tRNA) that binds to a corresponding codon in messenger RNA (mRNA) and designates a specific amino acid during protein synthesis.

Which of the following statements about transcription is not correct?

  1. Transcription is the first step of gene expression.

  2. Transcription is a process that involves the transcribing of genetic information from DNA to RNA.

  3. The coding region of a gene is bounded near the 5' end by a start codon.

  4. The regulatory sequence before the coding sequence is called the 3'UTR.

  5. DNA is read from 3'UTR → 5'UTR during transcription.

Show answer
Correct Option: D
Explanation:

This option is correct because the regulatory sequence before the coding sequence is called the five prime untranslated region (5'UTR).

_______ is a database for Drosophila genetics and molecular biology.

  1. GenBank

  2. Atlas

  3. FlyBase

  4. OMIM

  5. DDBJ

Show answer
Correct Option: C
Explanation:

This option is correct because FlyBase is an online bioinformatics database and the primary repository of genetic and molecular data for the insect family Drosophilidae.

Which of the following is a database of human meiotic recombination hot spot DNA sequences?

  1. HUMHOT

  2. HERVd

  3. GASCO

  4. GeneMark

  5. BAGEL

Show answer
Correct Option: A
Explanation:

This option is correct because HUMHOT is a database of human meiotic recombination hot spots.

Which of the following is a database for gene expression profiling with accompanying clinical information of human cancer tissues?

  1. PODB

  2. HGPD

  3. CGED

  4. PROMISCUOUS

  5. ChemProt

Show answer
Correct Option: C
Explanation:

This option is correct because CGED (Cancer gene expression database)is a database for gene expression profiling with accompanying clinical information of human cancer tissues.

Which of the following is a tool for predicting targets of small RNA action in bacteria?

  1. tmRDB

  2. TargetRNA

  3. IRESite

  4. RsiteDB

  5. SCOR

Show answer
Correct Option: B
Explanation:

This option is correct because TargetRNA is a tool for predicting targets of small RNA action in bacteria. It identifies targets of small (non-coding) RNA action.

Which of the following is an enzyme used to generate complementary DNA from an RNA template?

  1. DNA gyrase

  2. Reverse transcriptase

  3. DNA ligase

  4. Restriction endonuclease

  5. DNA topoisomerase

Show answer
Correct Option: B
Explanation:

This option is correct because Reverse transcriptase (RT) is an enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription.

The database of protein similarities created using distributed computing, which is freely accessible for scientific purposes, is

  1. RefSeq

  2. SIMAP

  3. TreeFam

  4. InterPro

  5. ModBase

Show answer
Correct Option: B
Explanation:

This option is correct because Similarity Matrix of Proteins (SIMAP) is a database of protein similarities created using distributed computing, which is freely accessible for scientific purposes.

Which of the following is a multi-organism database linking genotype to phenotype?

  1. Dryad

  2. PhenomicDB

  3. PHI-base

  4. CTD

  5. TRANSFAC

Show answer
Correct Option: B
Explanation:

This option is correct because PhenomicDB is a multi-organism database linking genotype to phenotype.

______ contains extensive information on metabolic pathways and enzymes from many organisms.

  1. NetPath

  2. MANET

  3. Reactome

  4. MetaCyc

  5. PhenomicDB

Show answer
Correct Option: D
Explanation:

 MetaCyc database contains extensive information on metabolic pathways and enzymes from many organisms.

Which of the following is the genomic tRNA database containing tRNA gene predictions made by the program tRNAscan-SE on complete genomes?

  1. Rfam

  2. piRNABank

  3. GtRNAdb

  4. SILVA

  5. lncRNAdb

Show answer
Correct Option: C
Explanation:

This option is correct because GtRNAdb is a genomic tRNA database containing tRNA gene predictions made by the program tRNAscan-SE on complete or nearly complete genomes.

Which of the following databases is the collection of online databases dealing with genomes, enzymatic pathways and biological chemicals?

  1. TIGRFAMs

  2. Pfam

  3. ProDom

  4. KEGG

  5. MUMmer

Show answer
Correct Option: D
Explanation:

This option is correct because Kyoto Encyclopedia of Genes and Genomes (KEGG) is a collection of online databases dealing with genomes, enzymatic pathways and biological chemicals.

The general purpose multiple sequence alignment program for DNA is

  1. TRANSFAC

  2. Melanie

  3. FASTA

  4. ClustalW2

  5. PROSITE

Show answer
Correct Option: D
Explanation:

 ClustalW2 is a general purpose multiple sequence alignment program for DNA or proteins.

The general purpose multiple sequence alignment program for DNA is

  1. TRANSFAC

  2. Melanie

  3. FASTA

  4. ClustalW2

  5. PROSITE

Show answer
Correct Option: D
Explanation:

 ClustalW2 is a general purpose multiple sequence alignment program for DNA or proteins.

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