0

Nucleus (Medical Entrance)

Description: Proteins
Number of Questions: 15
Created by:
Tags: Nucleus Nucleosome Sub nuclear bodies Nuclear Organisation Cell Nucleus
Attempted 0/15 Correct 0 Score 0

The nucleoplasmic veil, a structure inside the nucleoplasm, is made up of

  1. Emerin

  2. Nesprin

  3. LEM-3

  4. Chromatin


Correct Option: C
Explanation:

Nucleoplasmic veil is made up of LEM-3 lamins.

The cells which are incapable of producing daughter cells lack

  1. ribosomes

  2. cell membrane

  3. nucleus

  4. nuclear membrane


Correct Option: C
Explanation:

Nucleus or nucleus-like structures like nucleoid are required to divide and produce daughter cells. Cells incapable to produce daughter cells lack nucleus

Mutation in lamin A/C genes results in

  1. Greenberg dysplasia

  2. Progeria

  3. Mandibuloacral dysplasia with type B lipodystrophy

  4. Emery-Dreifuss muscular dystrophy, X-linked (EDMD)


Correct Option: B
Explanation:

Progeria is caused by mutation in A/C genes which causes the appearance of premature aging in its sufferers.

Nucleus was first observed by A. V. Leeuwenhoek in

  1. human red blood cells

  2. sea urchin eggs

  3. salmon red blood cells

  4. orchid flowers


Correct Option: C
Explanation:

Microscopist Antonie van Leeuwenhoek (1632–1723), observed the nucleus in the red blood cells of salmon.

Anti-nuclear antibodies (ANA) have been observed in

  1. Ménière's disease

  2. Systemic lupus erythematosus

  3. Restless leg syndrome

  4. Autoimmune uveitis


Correct Option: B
Explanation:

Anti-nuclear antibodies (ANA) have been observed in Systemic lupus erythematosus, which is an autoimmune disease.

Where does the transcription of rDNA occur?

  1. FC region of nucleolus

  2. FC region or FC-DFC boundary

  3. DFC region

  4. GC-DFC boundary


Correct Option: B
Explanation:

This is the correct option. Transcription of rDNA takes place either in FC region or at FC-DFC boundary.

Which of the following statements about nucleus is true?

  1. Nucleus possesses a membrane bound organelle called nucleolus.

  2. Nucleus serves as a power house of the cell.

  3. Cells without a membrane bound nucleus cannot divide.

  4. Nucleus was the first organelle to be discovered.


Correct Option: D
Explanation:

Nucleus was the first organelle to be discovered. It was first noticed by Antonie van Leeuwenhoek.

Which of the following processes does not occur in nucleus?

  1. Transcription

  2. Translation

  3. Control of gene expression

  4. Replication


Correct Option: B
Explanation:

Translation of proteins occurs outside the nucleus in the cytoplasm.

Which of the following are the largest sub-units passing through the nuclear pores?

  1. mRNAs

  2. Assembled ribosomal sub-units

  3. Cajal bodies

  4. Splicing speckles


Correct Option: B
Explanation:

Assembled ribosomal units are the largest sub-units that can pass through nuclear pores.

Which structure provides aqueous channel through nuclear envelope?

  1. Nuclear basket

  2. Nuclear pores

  3. Nucleosomes

  4. Ribosomes


Correct Option: B
Explanation:

Nuclear pores provide aqueous channels through the envelope. These are composed of multiple proteins called nucleoproteins.

Paraspeckle, a sub-nuclear body, is absent during

  1. telophase

  2. interphase

  3. metaphase

  4. anaphase


Correct Option: A
Explanation:

During telophase, when the two daughter nuclei are formed, there is no RNA Pol II transcription. So, the protein components like paraspeckles instead form a perinucleolar cap. Thus, they are absent in telophase.

Promyelocytic leukemia (PML) bodies are found in/on

  1. nucleolus

  2. nucleoplasm

  3. nuclear lamina

  4. chromosomes


Correct Option: B
Explanation:

Promyelocytic leukemia bodies are found in nucleoplasm. These are non-membrane-delineated bodies. They are involved in assemblage of nuclear bodies.

Small intranuclear rods are seen in

  1. paramyotonia congenita

  2. nemaline myopathy

  3. centronuclear myopathies,

  4. hyperthyroid myopathy


Correct Option: B
Explanation:

Small intranuclear rods are seen in nemaline myopathy; nemaline myopathy is an inherited myopathy, a group of diseases that causes problems with the tone and contraction of skeletal muscles.

Cajal bodies are associated with

  1. DNA replication

  2. transcription

  3. RNA processing

  4. snRNP biogenesis


Correct Option: C
Explanation:

Cajal bodies are involved in a number of roles in RNA processing like snRNA maturation and histone mRNA modification.

"They are located next to the transcriptionally active chromatin and are hypothesised to be the site of active pre-mRNA processing".

The above statement refers to which sub-nuclear body?

  1. Paraspeckles

  2. Splicing speckles

  3. Perichromatin fibrils

  4. RAFA and PTF domains


Correct Option: C
Explanation:

Perichromatin fibrils are located next to the transcriptionally active chromatin and is hypothesised to be the site of active pre-mRNA processing.

- Hide questions